Luisa R. Galieva
Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders
Galieva, Luisa R.; James, Victoria; Mukhamedshina, Yana O.; Rizvanov, Albert A.
Authors
VICTORIA JAMES VICTORIA.JAMES@NOTTINGHAM.AC.UK
Professor of Molecular Biology
Yana O. Mukhamedshina
Albert A. Rizvanov
Abstract
The use of extracellular vesicles (EVs) as cell free therapy is a promising approach to stimulate tissue regeneration including that of the nervous system. EVs transfer bioactive proteins and lipids, RNA and microRNAs, which play a relevant role in EV-mediated intercellular communication. The immunomodulatory, anti-inflammatory, and neuroprotective effects of mesenchymal stem cells-derived EVs have been well studied, knowledge of this paracrine mechanism and the availability of these cells, positions mesenchymal stem cells as a potential source of EVs for cell free therapy for a variety of regenerative and nervous system disorders. In this review, we focus on the immunomodulatory and neuroprotective effects of stem cells-derived EVs within in vitro and in vivo models of nerve disorders.
Citation
Galieva, L. R., James, V., Mukhamedshina, Y. O., & Rizvanov, A. A. (2019). Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders. Frontiers in Neuroscience, 13, Article 163. https://doi.org/10.3389/fnins.2019.00163
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Feb 12, 2019 |
| Online Publication Date | Mar 5, 2019 |
| Publication Date | Mar 5, 2019 |
| Deposit Date | Mar 5, 2019 |
| Publicly Available Date | Mar 5, 2019 |
| Journal | Frontiers in Neuroscience |
| Print ISSN | 1662-4548 |
| Publisher | Frontiers Media |
| Peer Reviewed | Peer Reviewed |
| Volume | 13 |
| Article Number | 163 |
| DOI | https://doi.org/10.3389/fnins.2019.00163 |
| Public URL | https://nottingham-repository.worktribe.com/output/1610104 |
| Publisher URL | https://www.frontiersin.org/articles/10.3389/fnins.2019.00163/full |
| Contract Date | Mar 5, 2019 |
Files
fnins-13-00163
(784 Kb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
You might also like
The Role of Extracellular Vesicles in Allergic Sensitization: A Systematic Review
(2024)
Journal Article
SnoRNAs in cardiovascular development, function, and disease
(2024)
Journal Article
Small non-coding RNA landscape of extracellular vesicles from an experimental model of equine osteoarthritis
(2023)
Presentation / Conference Contribution
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search