Eicosapentaenoic acid and aspirin, alone and in combination, for the prevention of colorectal adenomas (seAFOod Polyp Prevention trial): a multicentre, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial

Hull, Mark A.; Sprange, Kirsty; Hepburn, Trish; Tan, Wei; Shafayat, Aisha; Rees, Colin J.; Clifford, Gayle; Logan, Richard F.; Loadman, Paul M; Williams, Elizabeth A; Whitham, Diane; Montgomery, Alan A.; seAFOod Collaborative Group

Abstract

© 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Background
The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) and aspirin both have proof of concept for colorectal cancer chemoprevention, aligned with an excellent safety profile. Therefore, we aimed to test the efficacy of EPA and aspirin, alone and in combination and compared with a placebo, in individuals with sporadic colorectal neoplasia detected at colonoscopy.
Methods
In a multicentre, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial, patients aged 55–73 years who were identified during colonoscopy as being at high risk in the English Bowel Cancer Screening Programme (BCSP; ≥3 adenomas if at least one was ≥10 mm in diameter or ≥5 adenomas if these were

Citation

Hull, M. A., Sprange, K., Hepburn, T., Tan, W., Shafayat, A., Rees, C. J., Clifford, G., Logan, R. F., Loadman, P. M., Williams, E. A., Whitham, D., Montgomery, A. A., & seAFOod Collaborative Group. (2018). Eicosapentaenoic acid and aspirin, alone and in combination, for the prevention of colorectal adenomas (seAFOod Polyp Prevention trial): a multicentre, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial. Lancet, 392(10164), 2583-2594. https://doi.org/10.1016/S0140-6736%2818%2931775-6

• Journal Article Type: Article
• Acceptance Date: Nov 19, 2018
• Online Publication Date: Nov 19, 2018
• Publication Date: Dec 15, 2018
• Deposit Date: Nov 21, 2018
• Publicly Available Date: Nov 22, 2018
• Journal: The Lancet
• Print ISSN: 0140-6736
• Electronic ISSN: 1474-547X
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 392
• Issue: 10164
• Pages: 2583-2594
• DOI: https://doi.org/10.1016/S0140-6736%2818%2931775-6
• Keywords: General Medicine
• Public URL: https://nottingham-repository.worktribe.com/output/1297453
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0140673618317756?via%3Dihub
• Contract Date: Nov 22, 2018