Reactive clusters on a membrane

Thul, Ruediger; Falcke, Martin

Abstract

We investigate the reaction dynamics of diffusive molecules with immobile binding partners. The fixed reactants build clusters that comprise just a few tens of molecules, which leads to small cluster sizes. These molecules participate in the reaction only if they are activated. The dynamics of activation is mapped to a time-dependent size of an active region within the cluster. We focus on the deterministic description of the dynamics of a single cluster. The
spatial setup accounts for one of the most important determinants of the dynamics of a cluster, i.e. diffusional transport of reaction partners toward or away from the active region of the cluster. We provide numerical and analytical evidence that diffusion influences decisively the dynamic regimes of the reactions. The application of our methods to intracellular Ca²⁺ dynamics shows that large local concentrations saturate the Ca²⁺ feedback to the channel state control. That eliminates oscillations depending on this feedback.

Citation

Thul, R., & Falcke, M. (2005). Reactive clusters on a membrane. Physical Biology, 2, https://doi.org/10.1088/1478-3967/2/1/007

• Journal Article Type: Article
• Publication Date: Jan 1, 2005
• Deposit Date: Nov 19, 2008
• Publicly Available Date: Nov 19, 2008
• Journal: Physical Biology
• Electronic ISSN: 1478-3975
• Publisher: IOP Publishing
• Peer Reviewed: Peer Reviewed
• Volume: 2
• DOI: https://doi.org/10.1088/1478-3967/2/1/007
• Public URL: https://nottingham-repository.worktribe.com/output/1020745
• Publisher URL: http://www.iop.org/EJ/abstract/-search=59057501.2/1478-3975/2/1/007