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Outputs (194)

Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers (2024)
Journal Article
Alhasani, A., Modasia, A., Anodiyil, M., Corsetti, M., Aliyu, A., Crooks, C., MARCIANI, L., Reid, J., Yakubov, G., Avery, A., Harris, H., Warren, F., & Spiller, R. (2024). Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers. Journal of Nutrition, https://doi.org/10.1016/j.tjnut.2024.12.017

Background
Recent studies show that the increase in breath hydrogen (BH2) and symptoms after ingestion of inulin are reduced by coadministering psyllium (PI).

Objectives
To determine if slowing delivery of inulin to the colon by administering it... Read More about Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers.

Metabolomic characterisation of the glioblastoma invasive margin reveals a region-specific signature (2024)
Journal Article
Wood, J., Smith, S. J., Castellanos-Uribe, M., Lourdusamy, A., May, S. T., Barrett, D. A., Grundy, R. G., Kim, D.-H., & Rahman, R. (2025). Metabolomic characterisation of the glioblastoma invasive margin reveals a region-specific signature. Heliyon, 11(1), Article e41309. https://doi.org/10.1016/j.heliyon.2024.e41309

Isocitrate dehydrogenase wild-type glioblastoma (GBM) is characterised by a heterogeneous genetic landscape resulting from dynamic competition between tumour subclones to survive selective pressures. Improvements in metabolite identification and meta... Read More about Metabolomic characterisation of the glioblastoma invasive margin reveals a region-specific signature.

Collagen type III formation but not degradation is associated with risk of kidney disease progression and mortality after acute kidney injury (2024)
Journal Article
Sparding, N., Genovese, F., Karsdal, M. A., & Selby, N. M. (2025). Collagen type III formation but not degradation is associated with risk of kidney disease progression and mortality after acute kidney injury. Clinical Kidney Journal, 18(2), Article sfae413. https://doi.org/10.1093/ckj/sfae413

Background

Acute kidney injury (AKI), a rapid decrease in kidney function, is associated with increased risk of adverse outcomes including development and progression of CKD. Kidney fibrosis is one of the pathological processes central to this AKI... Read More about Collagen type III formation but not degradation is associated with risk of kidney disease progression and mortality after acute kidney injury.

The best ovarian reserve marker to predict ovarian response following controlled ovarian hyperstimulation: a systematic review and meta-analysis (2024)
Journal Article
Salemi, F., Jambarsang, S., Kheirkhah, A., Salehi-Abargouei, A., Ahmadnia, Z., hosseini, H. A., Lotfi, M., & Amer, S. (2024). The best ovarian reserve marker to predict ovarian response following controlled ovarian hyperstimulation: a systematic review and meta-analysis. Systematic Reviews, 13, Article 303. https://doi.org/10.1186/s13643-024-02684-0

Background:

One of the most challenging aspects of treating patients facing primary ovarian insufficiency, especially those eligible for controlled ovarian hyperstimulation (COH), is the assessment of ovarian function and response to stimulatory... Read More about The best ovarian reserve marker to predict ovarian response following controlled ovarian hyperstimulation: a systematic review and meta-analysis.

Yttrium-Enriched Phosphate Glass-Ceramic Microspheres for Bone Cancer Radiotherapy Treatment (2024)
Journal Article
Milborne, B., Arjuna, A., Islam, T., Arafat, A., Layfield, R., Thompson, A., & Ahmed, I. (2024). Yttrium-Enriched Phosphate Glass-Ceramic Microspheres for Bone Cancer Radiotherapy Treatment. ACS Omega, 9(52), 50933-50944. https://doi.org/10.1021/acsomega.4c02825

This study presents the development and characterisation of high yttrium-content phosphate-based glass-ceramic microspheres for potential applications in bone cancer radiotherapy treatment. The microspheres produced via flame spheroidisa-tion, follow... Read More about Yttrium-Enriched Phosphate Glass-Ceramic Microspheres for Bone Cancer Radiotherapy Treatment.

Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation (2024)
Journal Article
Aliyu, A., Dellschaft, N., Hoad, C., Williams, H., Gaudoin, E., Sulaiman, S., Crooks, C., Gowland, P., Aran, A., Lange, R., Bois De Fer, B., Corsetti, M., Marciani, L., & Spiller, R. (2024). Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation. Clinical Pharmacology and Therapeutics, https://doi.org/10.1002/cpt.3532

Bisacodyl is a widely used laxative that stimulates both motility and secretion. Our aim was to exploit the unique capabilities of MRI to define bisacodyl's mode of action. Two placebo-controlled cross-over trials were performed, one using a single d... Read More about Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation.

Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation (2024)
Journal Article
Aliyu, A., Dellschaft, N., Hoad, C., Williams, H., Gaudoin, E., Sulaiman, S., Crooks, C., Gowland, P., Alexia, A., Lange, R., Bois de Fer, B., Corsetti, M., Marciani, L., & Spiller, R. (2024). Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation. Clinical Pharmacology and Therapeutics, https://doi.org/10.1002/cpt.3532

Bisacodyl is a widely used laxative that stimulates both motility and secretion. Our aim was to exploit the unique capabilities of MRI to define bisacodyl's mode of action. Two placebo-controlled cross-over trials were performed, one using a single d... Read More about Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation.

Patient‐reported outcomes in studies of diabetes technology: What matters (2024)
Journal Article
Liarakos, A. L., Crabtree, T. S., & Wilmot, E. G. (2024). Patient‐reported outcomes in studies of diabetes technology: What matters. Diabetes, Obesity and Metabolism, 26(S7), 59-73. https://doi.org/10.1111/dom.15858

In recent years, diabetes technologies have revolutionized the care of people with type1 diabetes (T1D). Emerging evidence suggests that people with type 2 diabetes (T2D) canexperience similar benefits from these advances in technology. While glycaem... Read More about Patient‐reported outcomes in studies of diabetes technology: What matters.