Outputs (733)

Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition (2021)
Preprint / Working Paper
Williams, S. A., Gwilt, M., Hock, R., Taylor, C., Loayza, J., Stevenson, C. W., Cassaday, H. J., & Bast, T. Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition

Hippocampal neural disinhibition, i.e. reduced GABAergic inhibition, is a key feature of schizophrenia pathophysiology. The hippocampus is an important part of the neural circuitry that controls fear conditioning and can also modulate prefrontal and... Read More about Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition.

DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift (2021)
Journal Article
Franzen, J., Georgomanolis, T., Selich, A., Kuo, C.-C., Stöger, R., Brant, L., Mulabdić, M. S., Fernandez-Rebollo, E., Grezella, C., Ostrowska, A., Begemann, M., Nikolić, M., Rath, B., Ho, A. D., Rothe, M., Schambach, A., Papantonis, A., & Wagner, W. (2021). DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift. Communications Biology, 4(1), Article 598. https://doi.org/10.1038/s42003-021-02116-y

Culture expansion of primary cells evokes highly reproducible DNA methylation (DNAm) changes. We have identified CG dinucleotides (CpGs) that become continuously hyper- or hypomethylated during long-term culture of mesenchymal stem cells (MSCs) and o... Read More about DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift.

Mechanisms of umami taste perception: From molecular level to brain imaging (2021)
Journal Article
Wu, B., Eldeghaidy, S., Ayed, C., Fisk, I. D., Hewson, L., & Liu, Y. (2022). Mechanisms of umami taste perception: From molecular level to brain imaging. Critical Reviews in Food Science and Nutrition, 62(25), 7015-7024. https://doi.org/10.1080/10408398.2021.1909532

Due to unique characteristics, umami substances have gained much attention in the food industry during the past decade as potential replacers to sodium or fat to increase food palatability. Umami is not only known to increase appetite, but also to in... Read More about Mechanisms of umami taste perception: From molecular level to brain imaging.

Application of sodium selenate to cowpea (Vigna unguiculata L.) increases shoot and grain Se partitioning with strong genotypic interactions (2021)
Journal Article
Silva, V. M., Nardeli, A. J., Mendes, N. A. C., Alcock, T. D., Rocha, M. D. M., Putti, F. F., Wilson, L., Young, S. D., Broadley, M. R., White, P. J., & Reis, A. R. D. (2021). Application of sodium selenate to cowpea (Vigna unguiculata L.) increases shoot and grain Se partitioning with strong genotypic interactions. Journal of Trace Elements in Medicine and Biology, 67, Article 126781. https://doi.org/10.1016/j.jtemb.2021.126781

Backgorund: Cowpea is a crop widely used in developing countries due its rusticity. Besides its rich genotypic variability, most breeding programs do not explore its potential to improve elements uptake. Selenium (Se) is a scarce element in most soil... Read More about Application of sodium selenate to cowpea (Vigna unguiculata L.) increases shoot and grain Se partitioning with strong genotypic interactions.

Environmental and human iodine and selenium status: lessons from Gilgit-Baltistan, North-East Pakistan (2021)
Journal Article
Ahmad, S., Bailey, E. H., Arshad, M., Ahmed, S., Watts, M. J., Stewart, A. G., & Young, S. D. (2021). Environmental and human iodine and selenium status: lessons from Gilgit-Baltistan, North-East Pakistan. Environmental Geochemistry and Health, 43, 4665–4686. https://doi.org/10.1007/s10653-021-00943-w

Iodine and selenium deficiencies are common worldwide. We assessed the iodine and selenium status of Gilgit-Baltistan, Pakistan. We determined the elemental composition (ICP-MS) of locally grown crops (n = 281), drinking water (n = 82), urine (n = 45... Read More about Environmental and human iodine and selenium status: lessons from Gilgit-Baltistan, North-East Pakistan.

Reply to: Timing of puberty — body size or reproductive optimization? (2021)
Journal Article
Bentley, G. R., Bogin, B. A., Bar-Sadeh, B., Stöger, R., & Melamed, P. (2021). Reply to: Timing of puberty — body size or reproductive optimization?. Nature Reviews Endocrinology, 17, 573–574. https://doi.org/10.1038/s41574-021-00502-4

Magnesium and calcium overaccumulate in the leaves of a schengen3 mutant of Brassica rapa (2021)
Journal Article
Alcock, T. D., Thomas, C. L., Ó Lochlainn, S., Pongrac, P., Wilson, M., Moore, C., Reyt, G., Vogel-Mikuš, K., Kelemen, M., Hayden, R., Wilson, L., Stephenson, P., Østergaard, L., Irwin, J. A., Hammond, J. P., King, G. J., Salt, D. E., Graham, N. S., White, P. J., & Broadley, M. R. (2021). Magnesium and calcium overaccumulate in the leaves of a schengen3 mutant of Brassica rapa. Plant Physiology, 186(3), 1616-1631. https://doi.org/10.1093/PLPHYS/KIAB150

Magnesium (Mg) and calcium (Ca) are essential mineral nutrients poorly supplied in many human food systems. In grazing livestock, Mg and Ca deficiencies are costly welfare issues. Here, we report a Brassica rapa loss-of-function schengen3 (sgn3) muta... Read More about Magnesium and calcium overaccumulate in the leaves of a schengen3 mutant of Brassica rapa.

Terpene polyacrylate TPA5 shows favorable molecular hydrodynamic properties as a potential bioinspired archaeological wood consolidant (2021)
Journal Article
Cutajar, M., Andriulo, F., Thomsett, M. R., Moore, J. C., Couturaud, B., Howdle, S. M., Stockman, R. A., & Harding, S. E. (2021). Terpene polyacrylate TPA5 shows favorable molecular hydrodynamic properties as a potential bioinspired archaeological wood consolidant. Scientific Reports, 11(1), Article 7343. https://doi.org/10.1038/s41598-021-86543-1

There is currently a pressing need for the development of novel bioinspired consolidants for waterlogged, archaeological wood. Bioinspired materials possess many advantages, such as biocompatibility and sustainability, which makes them ideal to use i... Read More about Terpene polyacrylate TPA5 shows favorable molecular hydrodynamic properties as a potential bioinspired archaeological wood consolidant.

On the contribution of malt quality and the malting process to the formation of beer staling aldehydes: a review (2021)
Journal Article
De Cooman, L., Cook, D., Powell, C., Aerts, G., De Rouck, G., Bustillo Trueba, P., Ditrych, M., Jaskula‐Goiris, B., & Filipowska, W. (2021). On the contribution of malt quality and the malting process to the formation of beer staling aldehydes: a review. Journal of the Institute of Brewing, 127(2), 107-126. https://doi.org/10.1002/jib.644

Despite decades of extensive research, beer flavour instability remains a challenge for both brewing and malting industries. Malt impacts the brewing process as well as the quality of the final beer. It also affects the stability of beer flavour, as... Read More about On the contribution of malt quality and the malting process to the formation of beer staling aldehydes: a review.

Male seminal parameters are not associated with Leydig cell functional capacity in men (2021)
Journal Article
Anand‐Ivell, R., Tremellen, K., Soyama, H., Enki, D., & Ivell, R. (2021). Male seminal parameters are not associated with Leydig cell functional capacity in men. Andrology, 9(4), 1126-1136. https://doi.org/10.1111/andr.13001

Background: Insulin-like peptide 3 (INSL3) is a constitutive, secreted peptide produced in the male uniquely by the Leydig cells of the testes. It is a biomarker for Leydig cell functional capacity, which is a measure of the numbers and differentiati... Read More about Male seminal parameters are not associated with Leydig cell functional capacity in men.