Outputs (32)

Microparticles for controlled GDF6 delivery to direct ASC?based nucleus pulposus regeneration (2019)
Journal Article
Hodgkinson, T., Stening, J. Z., White, L. J., Shakesheff, K. M., Hoyland, J. A., & Richardson, S. M. (2019). Microparticles for controlled GDF6 delivery to direct ASC?based nucleus pulposus regeneration. Journal of Tissue Engineering and Regenerative Medicine, 13(8), 1406-1417. https://doi.org/10.1002/term.2882

Currently, there is no effective long-term treatment for intervertebral disc degeneration (IVDD), making it an attractive candidate for regenerative therapies. Hydrogel delivery of adipose stem cells (ASCs) in combination with controlled release of b... Read More about Microparticles for controlled GDF6 delivery to direct ASC?based nucleus pulposus regeneration.

Targeted protein delivery: carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds (2019)
Journal Article
Tanase, C. E., Qutachi, O., White, L. J., Shakesheff, K. M., McCaskie, A. W., Best, S. M., & Cameron, R. E. (2019). Targeted protein delivery: carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds. Regenerative Biomaterials, 6(5), 279-287. https://doi.org/10.1093/rb/rbz015

Tissue engineering response may be tailored via controlled, sustained release of active agents from protein loaded degradable microparticles incorporated directly within 3D ice-templated collagen scaffolds. However, the effects of covalent crosslink... Read More about Targeted protein delivery: carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds.

A thermoresponsive three-dimensional fibrous cell culture platform for enzyme-free expansion of mammalian cells (2019)
Journal Article
Aladdad, A. M., Amer, M. H., Sidney, L., Hopkinson, A., White, L. J., Alexander, C., & Rose, F. R. (2019). A thermoresponsive three-dimensional fibrous cell culture platform for enzyme-free expansion of mammalian cells. Acta Biomaterialia, 95, 427-438. https://doi.org/10.1016/j.actbio.2019.01.037

A three-dimensional thermoresponsive fibrous scaffold system for the subsequent extended culture and enzyme-free passaging of a range of mammalian cell types is presented. Poly(PEGMA188) was incorporated with poly(ethylene terephthalate) (PET) via bl... Read More about A thermoresponsive three-dimensional fibrous cell culture platform for enzyme-free expansion of mammalian cells.

In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft (2018)
Journal Article
Rose, J., Sidney, L., Patient, J., White, L., Dua, H., El Haj, A., …Rose, F. (2018). In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft. Journal of Biomedical Materials Research Part A, 107(4), 828-838. https://doi.org/10.1002/jbm.a.36598

The advent of innovative surgical procedures utilizing partial thickness corneal grafts has created a need for the development of synthetic implants to recreate corneal stromal tissue. This work evaluates electrospun gelatin and polycaprolactone (PCL... Read More about In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft.

Translation of remote control regenerative technologies for bone repair (2018)
Journal Article
Markides, H., McLaren, J. S., Telling, N. D., Alom, N., Al-Mutheffer, E. A., Oreffo, R., …El-Haj, A. (2018). Translation of remote control regenerative technologies for bone repair. npj Regenerative Medicine, 3(9), 1-12. https://doi.org/10.1038/s41536-018-0048-1

The role of biomechanical stimuli, or mechanotransduction, in normal bone homeostasis and repair is understood to facilitate effective osteogenesis of mesenchymal stem cells (MSCs) in vitro. Mechanotransduction has been integrated into a multitude of... Read More about Translation of remote control regenerative technologies for bone repair.

A biomaterials approach to influence stem cell fate in injectable cell-based therapies (2018)
Journal Article
Amer, M. H., Rose, F. R., Shakesheff, K. M., & White, L. J. (2018). A biomaterials approach to influence stem cell fate in injectable cell-based therapies. Stem Cell Research and Therapy, 9(39), https://doi.org/10.1186/s13287-018-0789-1

Background: Numerous stem cell therapies use injection-based administration to deliver high density cell preparations. However, cell retention rates as low as 1% have been observed within days of transplantation. This study investigated the effects o... Read More about A biomaterials approach to influence stem cell fate in injectable cell-based therapies.

Peptide hydrogels — a tissue engineering strategy for the prevention of oesophageal strictures (2017)
Journal Article
Kumar, D., Workman, V., O'Brien, M. C., McLaren, J. S., White, L. J., Ragunath, K., …Rose, F. R. (2017). Peptide hydrogels — a tissue engineering strategy for the prevention of oesophageal strictures. Advanced Functional Materials, 27(38), Article 1702424. https://doi.org/10.1002/adfm.201702424

Endoscopic treatment of Barrett’s oesophagus often leads to further damage of healthy tissue causing fibrotic tissue formation termed as strictures. This study shows that synthetic, self-assembling peptide hydrogels (PeptiGelDesign) support the activ... Read More about Peptide hydrogels — a tissue engineering strategy for the prevention of oesophageal strictures.

Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges (2017)
Journal Article
Amer, M. H., Rose, F. R., Shakesheff, K. M., Modo, M., & White, L. J. (in press). Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges. npj Regenerative Medicine, 2, Article 23. https://doi.org/10.1038/s41536-017-0028-x

Significant progress has been made during the past decade towards the clinical adoption of cell- based therapeutics. However, existing cell delivery approaches have shown limited success, with numerous studies showing fewer than 5% of injected cells... Read More about Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges.

Decellularized bone extracellular matrix and human dental pulp stem cells as a construct for bone regeneration (2017)
Journal Article
Paduano, F., Marrelli, M., Alom, N., Amer, M. H., White, L. J., Shakesheff, K. M., & Tatullo, M. (in press). Decellularized bone extracellular matrix and human dental pulp stem cells as a construct for bone regeneration. Journal of Biomaterials Science, Polymer Edition, 28(8), https://doi.org/10.1080/09205063.2017.1301770

Dental pulp tissue represents a source of mesenchymal stem cells (MSCs) that have a strong differentiation potential towards the osteogenic lineage. The objective of the current study was to examine in vitro osteogenic induction of dental pulp stem c... Read More about Decellularized bone extracellular matrix and human dental pulp stem cells as a construct for bone regeneration.

Macrophage phenotype in response to ECM bioscaffolds (2017)
Journal Article
Huleihel, L., Dziki, J. L., Bartolacci, J. G., Rausch, T., Scarritt, M. E., Cramer, M. C., …Badylak, S. F. (2017). Macrophage phenotype in response to ECM bioscaffolds. Seminars in Immunology, 29, https://doi.org/10.1016/j.smim.2017.04.004

Macrophage presence and phenotype are critical determinants of the healing response following injury. Downregulation of the pro-inflammatory macrophage phenotype has been associated with the therapeutic use of bioscaffolds composed of extracellular... Read More about Macrophage phenotype in response to ECM bioscaffolds.