Outputs (2)

Mathematical modelling of carbohydrate and protein metabolism in muscle (2025)
Journal Article
Alharbi, B. M., Williams, H. E., Parr, T., Brameld, J. M., Fallaize, C., & Wattis, J. A. (2025). Mathematical modelling of carbohydrate and protein metabolism in muscle. Mathematical Biosciences, 386, Article 109455. https://doi.org/10.1016/j.mbs.2025.109455

We propose a mathematical model based on coupled ordinary differential equations (ODEs) for metabolite concentrations with the aim of investigating how modifications to the rates affects outputs from a regulatory network. Our aim is to model the rela... Read More about Mathematical modelling of carbohydrate and protein metabolism in muscle.

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth (2016)
Journal Article
Brown, D. M., Williams, H., Ryan, K., Wilson, T., Daniel, Z. C., Mareko, M. H. D., Emes, R. D., Harris, D. W., Wattis, J. A., Dryden, I. L., Hodgman, T. C., Brameld, J. M., & Parr, T. (2016). Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth. Scientific Reports, 6(1), https://doi.org/10.1038/srep28693

We aimed to identify novel molecular mechanisms for muscle growth during administration of anabolic agents. Growing pigs (Duroc/(Landrace/Large-White)) were administered Ractopamine (a beta-adrenergic agonist; BA; 20ppm in feed) or Reporcin (recombin... Read More about Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth.