Outputs (588)

Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization (2022)
Journal Article
Shur, N. F., Simpson, E. J., Crossland, H., Chivaka, P. K., Constantin, D., Cordon, S. M., Constantin-Teodosiu, D., Stephens, F. B., Lobo, D. N., Szewczyk, N., Narici, M., Prats, C., Macdonald, I. A., & Greenhaff, P. L. (2022). Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization. Journal of Cachexia, Sarcopenia and Muscle, 13(6), 2999-3013. https://doi.org/10.1002/jcsm.13075

Background: Bed rest (BR) reduces whole-body insulin-stimulated glucose disposal (GD) and alters muscle fuel metabolism, but little is known about metabolic adaptation from acute to chronic BR nor the mechanisms involved, particularly when volunteers... Read More about Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization.

The active form of Helicobacter pylori vacuolating cytotoxin induces decay-accelerating factor CD55 in association with intestinal metaplasia in the human gastric mucosa (2022)
Journal Article
Kaneko, K., Zaitoun, A. M., Letley, D. P., Rhead, J. L., Torres, J., Spendlove, I., Atherton, J. C., & Robinson, K. (2022). The active form of Helicobacter pylori vacuolating cytotoxin induces decay-accelerating factor CD55 in association with intestinal metaplasia in the human gastric mucosa. Journal of Pathology, https://doi.org/10.1002/path.5990

High-level expression of decay-accelerating factor, CD55, has previously been found in human gastric cancer (GC) and intestinal metaplasia (IM) tissues. Therapeutic effects of CD55 inhibition in cancer have been reported. However, the role of Helicob... Read More about The active form of Helicobacter pylori vacuolating cytotoxin induces decay-accelerating factor CD55 in association with intestinal metaplasia in the human gastric mucosa.

A pen in the liver (2022)
Journal Article
Barrie, J., & Lobo, D. N. (2022). A pen in the liver. Radiology Case Reports, 17(10), 3992-3995. https://doi.org/10.1016/j.radcr.2022.07.096

A 24-year-old woman with anxiety, depression, and emotionally unstable personality disorder was referred to a tertiary center 2 weeks after ingesting multiple foreign bodies. She had undergone a laparoscopic cholecystectomy and a laparotomy for extra... Read More about A pen in the liver.

Randomised clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis (2022)
Journal Article
Herrod, P. J. J., Kwok, A. T., & Lobo, D. N. (2022). Randomised clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis. BJS Open, 6(4), Article zrac100

Background
This aim of this study was to provide an updated meta-analysis comparing antibiotic therapy with appendicectomy in adults (16 years or older) with uncomplicated acute appendicitis.

Methods
A search for randomized clinical trials compa... Read More about Randomised clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis.

Hyoscine butylbromide mode of action on bowel motility: From pharmacology to clinical practice (2022)
Journal Article
Corsetti, M., Forestier, S., & Jiménez, M. (2023). Hyoscine butylbromide mode of action on bowel motility: From pharmacology to clinical practice. Neurogastroenterology and Motility, 35(4), Article e14451. https://doi.org/10.1111/nmo.14451

Background: Hyoscine butylbromide (HBB) has been available for use as an antispasmodic since 1951 and is indicated for the treatment of abdominal pain associated with cramps. A previous review in 2007 summarized the evidence on the mode of action of... Read More about Hyoscine butylbromide mode of action on bowel motility: From pharmacology to clinical practice.

Digital Follow-Up After Elective Laparoscopic Cholecystectomy: A Feasibility Study (2022)
Journal Article
Daliya, P., Carvell, J., Rozentals, J., Lobo, D. N., & Parsons, S. L. (2022). Digital Follow-Up After Elective Laparoscopic Cholecystectomy: A Feasibility Study. World Journal of Surgery, 46, 2648-2658. https://doi.org/10.1007/s00268-022-06684-w

Background: Although recommendations exist for patients to be offered a post-operative helpline or telephone follow-up appointment at discharge after cholecystectomy, implementation of these is resource-intensive. Whilst the benefits of telephone fol... Read More about Digital Follow-Up After Elective Laparoscopic Cholecystectomy: A Feasibility Study.

A new framework for advancing in drug-induced liver injury research. The Prospective European DILI Registry (2022)
Journal Article
Björnsson, E. S., Stephens, C., Atallah, E., Alvarez-Alvarez, I., Robles-Diaz, M., Gerbes, A., Weber, S., Stirnimann, G., Kullak-Ublick, G., Cortez-Pinto, H., Grove, J. I., Lucena, M. I., Andrade, R. J., & Aithal, G. P. (2022). A new framework for advancing in drug-induced liver injury research. The Prospective European DILI Registry. Liver International, 43(1), 115-126. https://doi.org/10.1111/liv.15378

Background & Aims: No multi-national prospective study of drug-induced liver injury (DILI) has originated in Europe. The design of a prospective European DILI registry, clinical features and short-term outcomes of the cases and controls is reported.... Read More about A new framework for advancing in drug-induced liver injury research. The Prospective European DILI Registry.

Predicting Need for Escalation of Care or Death From Repeated Daily Clinical Observations and Laboratory Results in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 (2022)
Journal Article
Crooks, C. J., West, J., Fogarty, A., Morling, J. R., Grainge, M. J., Gonem, S., Simmonds, M., Race, A., Juurlink, I., Briggs, S., Cruickshank, S., Hammond-Pears, S., & Card, T. R. (2022). Predicting Need for Escalation of Care or Death From Repeated Daily Clinical Observations and Laboratory Results in Patients With Severe Acute Respiratory Syndrome Coronavirus 2. American Journal of Epidemiology, 191(11), 1944-1953. https://doi.org/10.1093/aje/kwac126

We compared the performance of prognostic tools for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using parameters fitted either at the time of hospital admission or across all time points of an admission. This cohort study used clinic... Read More about Predicting Need for Escalation of Care or Death From Repeated Daily Clinical Observations and Laboratory Results in Patients With Severe Acute Respiratory Syndrome Coronavirus 2.

O038 Digital consent: modernising data-sharing in surgery and empowering patients (2022)
Journal Article
Daliya, P., Lobo, D., & Parsons, S. (2022). O038 Digital consent: modernising data-sharing in surgery and empowering patients. British Journal of Surgery, 109(Supplement_4), Article znac242.038. https://doi.org/10.1093/bjs/znac242.038

Introduction Despite the 2015 Montgomery Ruling highlighting key requisites for informed consent, little has changed to modernise data-sharing and documentation of the consent process. Although many practitioners provide supplementary information to... Read More about O038 Digital consent: modernising data-sharing in surgery and empowering patients.

The Duration and Magnitude of Postdischarge Venous Thromboembolism Following Colectomy (2022)
Journal Article
Lewis-Lloyd, C. A., Humes, D. J., West, J., Peacock, O., & Crooks, C. J. (2022). The Duration and Magnitude of Postdischarge Venous Thromboembolism Following Colectomy. Annals of Surgery, 276(3), E177-E184. https://doi.org/10.1097/SLA.0000000000005563

Objective: To assess the impact of current guidelines by reporting weekly postoperative postdischarge venous thromboembolism (VTE) rates. Summary Background Data: Disparity exists between the postoperative thromboprophylaxis duration colectomy patien... Read More about The Duration and Magnitude of Postdischarge Venous Thromboembolism Following Colectomy.