Hyoscine butylbromide mode of action on bowel motility: From pharmacology to clinical practice

Corsetti, Maura; Forestier, Sylvie; Jiménez, Marcel

Abstract

Background: Hyoscine butylbromide (HBB) has been available for use as an antispasmodic since 1951 and is indicated for the treatment of abdominal pain associated with cramps. A previous review in 2007 summarized the evidence on the mode of action of HBB in vitro and in vivo in both animal and human studies. However, since then, novel publications have appeared within the literature and also our knowledge of what represents normal motility in humans has evolved. Purpose: This review is the result of the collaboration between a basic scientist and clinicians with the aim of providing an updated overview of the mechanisms of action of HBB and its clinical efficacy to guide not only use in clinical practice, but also future research.

Citation

Corsetti, M., Forestier, S., & Jiménez, M. (2023). Hyoscine butylbromide mode of action on bowel motility: From pharmacology to clinical practice. Neurogastroenterology and Motility, 35(4), Article e14451. https://doi.org/10.1111/nmo.14451

• Journal Article Type: Article
• Acceptance Date: Aug 1, 2022
• Online Publication Date: Aug 16, 2022
• Publication Date: 2023-04
• Deposit Date: Aug 2, 2022
• Publicly Available Date: Aug 17, 2023
• Journal: Neurogastroenterology and Motility
• Print ISSN: 1350-1925
• Electronic ISSN: 1365-2982
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 35
• Issue: 4
• Article Number: e14451
• DOI: https://doi.org/10.1111/nmo.14451
• Keywords: Gastroenterology; Endocrine and Autonomic Systems; Physiology
• Public URL: https://nottingham-repository.worktribe.com/output/9581310
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1111/nmo.14451