Outputs (588)

Using MRI to study the alterations in liver blood flow, perfusion and oxygenation in response to physiological stress challenges: meal, hyperoxia and hypercapnia (2018)
Journal Article
Cox, E. F., Palaniyappan, N., Aithal, G. P., Guha, I. N., & Francis, S. T. (in press). Using MRI to study the alterations in liver blood flow, perfusion and oxygenation in response to physiological stress challenges: meal, hyperoxia and hypercapnia. Journal of Magnetic Resonance Imaging,

Background: Non-invasive assessment of dynamic changes in liver blood flow, perfusion and oxygenation using magnetic resonance imaging (MRI) may allow detection of subtle haemodynamic alterations in cirrhosis.
Purpose: To assess the feasibility of... Read More about Using MRI to study the alterations in liver blood flow, perfusion and oxygenation in response to physiological stress challenges: meal, hyperoxia and hypercapnia.

Intestinal failure in adults: recommendations from the ESPEN Expert Groups (2018)
Journal Article
Pironi, L., Corcos, O., Forbes, A., Holst, M., Joly, F., Jonkers, C., Klek, S., Lal, S., Reintam Blaser, A., Rollins, K. E., Sasdelli, A. S., Schaffer, J., Van Gossum, A., Wanten, G., Zanfi, C., Lobo, D. N., & ESPEN Acute and Chronic Intestinal Failure Special Interest Groups. (2018). Intestinal failure in adults: recommendations from the ESPEN Expert Groups. Clinical Nutrition, 36(6A), 1798-1809. https://doi.org/10.1016/j.clnu.2018.07.036

Background and aims: Intestinal failure (IF) is defined as “the reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that intravenous supplementation is required to maintain h... Read More about Intestinal failure in adults: recommendations from the ESPEN Expert Groups.

The reporting on ERAS Compliance, Outcomes, and Elements Research (RECOvER) checklist: a joint statement by the ERAS® and ERAS® USA societies (2018)
Journal Article
Elias, K. M., Stone, A. B., McGinigle, K., Tankou, J. I., Scott, M. J., Fawcett, W. J., Demartines, N., Lobo, D. N., Ljungqvist, O., Urman, R. D., & the ERAS® Society and ERAS® USA. (2019). The reporting on ERAS Compliance, Outcomes, and Elements Research (RECOvER) checklist: a joint statement by the ERAS® and ERAS® USA societies. World Journal of Surgery, 43(1), 1-8. https://doi.org/10.1007/s00268-018-4753-0

Background: Enhanced Recovery After Surgery (ERAS) programs are multimodal care pathways designed to minimize the physiologic and psychological impact of surgery for patients. Increased compliance with ERAS guidelines is associated with improved pati... Read More about The reporting on ERAS Compliance, Outcomes, and Elements Research (RECOvER) checklist: a joint statement by the ERAS® and ERAS® USA societies.

The effect of exercise training on intrahepatic triglyceride and hepatic insulin sensitivity: a systematic review and meta-analysis (2018)
Journal Article
Sargeant, J. A., Gray, L. J., Bodicoat, D. H., Willis, S. A., Stensel, D. J., Nimmo, M. A., Aithal, G. P., & King, J. A. (2018). The effect of exercise training on intrahepatic triglyceride and hepatic insulin sensitivity: a systematic review and meta-analysis. Obesity Reviews, https://doi.org/10.1111/obr.12719

This systematic review and meta-analysis determined the impact of structured exercise training, and the influence of associated weight loss, on intrahepatic triglyceride (IHTG) in individuals with non-alcoholic fatty liver disease (NAFLD). It also ex... Read More about The effect of exercise training on intrahepatic triglyceride and hepatic insulin sensitivity: a systematic review and meta-analysis.

Time out of general surgery specialty training in the UK: a national database study (2018)
Journal Article
Elsey, E. J., West, J., Griffiths, G., & Humes, D. J. (2019). Time out of general surgery specialty training in the UK: a national database study. Journal of Surgical Education, 76(1), 55-64. https://doi.org/10.1016/j.jsurg.2018.06.011

Objective:General surgery specialty training in the UK takes 6 years and allows trainees to take time out of training. Studies from the USA have highlighted an increasing trend for taking time out of surgical training for research. This study aimed t... Read More about Time out of general surgery specialty training in the UK: a national database study.

Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging (2018)
Journal Article
Major, G., Murray, K., Singh, G., Nowak, A., Hoad, C. L., Marciani, L., Silos-Santiago, A., Kurtz, C. B., Johnston, J., Gowland, P., & Spiller, R. C. (2018). Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging. Neurogastroenterology and Motility, 30(9), Article e13400. https://doi.org/10.1111/nmo.13400

Background: In functional gastrointestinal disorders a lack of objective biomarkers limits evaluation of underlying mechanisms. We aimed to demonstrate the utility of Magnetic Resonance Imaging (MRI) for this task using psyllium, an effective constip... Read More about Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging.

A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects (2018)
Journal Article
Sloan, T. J., Jalanka, J., Major, G. A. D., Krishnasamy, S., Pritchard, S., Abdelrazig, S., Korpela, K., Singh, G., Mulvenna, C., Hoad, C. L., Marciani, L., Barrett, D. A., Lomer, M. C. E., de Vos, W. M., Gowland, P. A., & Spiller, R. C. (2018). A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects. PLoS ONE, 13(7), Article e0201410. https://doi.org/10.1371/journal.pone.0201410

Background & aims

Ingestion of poorly digested, fermentable carbohydrates (fermentable oligo-, di-, mono-saccharides and polyols; FODMAPs) have been implicated in exacerbating intestinal symptoms and the reduction of intake with symptom alleviatio... Read More about A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects.

Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial (2018)
Journal Article
Jankowski, J. A., de Caestecker, J., Love, S. B., Reilly, G., Watson, P., Sanders, S., Ang, Y., Morris, D., Bhandari, P., Attwood, S., Ragunath, K., Rameh, B., Fullarton, G., Tucker, A., Penman, I., Rodgers, C., Neale, J., Brooks, C., Wise, A., Jones, S., …Moayyedi, P. (2018). Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial. Lancet, 392(10145), 400-408. https://doi.org/10.1016/S0140-6736%2818%2931388-6

Background: Oesophageal adenocarcinoma (OA) is the sixth commonest cause of cancer death worldwide and Barrett’s oesophagus (BO) is the most significant risk factor. We evaluated the efficacy of high-dose esomeprazole proton pump inhibitor acid suppr... Read More about Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial.

ADAPT: an algorithm incorporating PRO-C3 accurately identifies patients with NAFLD and advanced fibrosis (2018)
Journal Article
Daniels, S. J., Leeming, D. J., Eslam, M., Hashem, A. M., Nielsen, M. J., Krag, A., Karsdal, M. A., Grove, J. I., Guha, I. N., Kawaguchi, T., Torimura, T., McLeod, D., Akiba, J., Kaye, P., de Boer, B., Aithal, G. P., Adams, L. A., & George, J. (2019). ADAPT: an algorithm incorporating PRO-C3 accurately identifies patients with NAFLD and advanced fibrosis. Hepatology, 69(3), 1075-1086. https://doi.org/10.1002/hep.30163

Background and Aim: Given the high global prevalence of non-alcoholic fatty liver disease (NAFLD), the need for relevant non-invasive biomarkers and algorithms to accurately stage disease severity is a critical unmet medical need. Identifying those w... Read More about ADAPT: an algorithm incorporating PRO-C3 accurately identifies patients with NAFLD and advanced fibrosis.

A comparison of two different software packages for the analysis of body composition using computed tomography images (2018)
Journal Article
Rollins, K. E., Awwad, A., MacDonald, I. A., & Lobo, D. N. (2019). A comparison of two different software packages for the analysis of body composition using computed tomography images. Nutrition, 57, 92-96. https://doi.org/10.1016/j.nut.2018.06.003

Objectives: Body composition analysis from computed tomography (CT) imaging has become widespread. However, the methodology used is far from established. Two main software packages are in common usage for body composition analysis, with results used... Read More about A comparison of two different software packages for the analysis of body composition using computed tomography images.