Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging

Major, Giles; Murray, Kathryn; Singh, Gulzar; Nowak, Adam; Hoad, Caroline L.; Marciani, Luca; Silos-Santiago, Ada; Kurtz, Caroline B.; Johnston, Jeffrey; Gowland, Penny; Spiller, Robin C.

Abstract

Background: In functional gastrointestinal disorders a lack of objective biomarkers limits evaluation of underlying mechanisms. We aimed to demonstrate the utility of Magnetic Resonance Imaging (MRI) for this task using psyllium, an effective constipation treatment, in patients and controls.

Methods: Two crossover studies: 1) adults without constipation (controls, n=9) took three treatments in randomised order for 6 days - maltodextrin (placebo), psyllium 3.5g t.d.s and 7g t.d.s.; 2) adults with chronic constipation (patients, n=20) took placebo and psyllium 7g t.d.s. for 6 days. MRI was performed fasting and postprandially on day 6. Measurements included small bowel and ascending colon water content, colonic volume, transit time and MR relaxometry (T1, T2) to assess colonic chyme. Stool water percentage was measured.

Results: 7g psyllium t.d.s. increased fasting colonic volumes in controls from median 372mL (IQR 284-601) to 578 mL (IQR 510-882), and in patients from median 831mL (IQR 745–934) to 1104mL (847–1316), P<0.05). Mean postprandial small bowel water was higher in controls and patients after 7g psyllium t.d.s. vs. placebo. Whole gut transit was slower in patients than controls (P <0.05). T1 of the descending colon chyme (fasting) was lower in patients [213ms, 176–420] than controls [440ms, 352–884, P <0.05] on placebo, but increased by 7 g psyllium t.d.s. [590ms, 446–1338), P<0.001]. Descending colon T1 correlated with baseline stool water content and stool frequency on treatment.

Conclusions and Inferences: MRI measurements can objectively demonstrate the mode of action of therapy targeting intestinal fluid content in constipation.

Citation

Major, G., Murray, K., Singh, G., Nowak, A., Hoad, C. L., Marciani, L., Silos-Santiago, A., Kurtz, C. B., Johnston, J., Gowland, P., & Spiller, R. C. (2018). Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging. Neurogastroenterology and Motility, 30(9), Article e13400. https://doi.org/10.1111/nmo.13400

• Journal Article Type: Article
• Acceptance Date: May 28, 2018
• Online Publication Date: Jul 30, 2018
• Publication Date: 2018-09
• Deposit Date: Jun 7, 2018
• Publicly Available Date: Jul 31, 2019
• Journal: Neurogastroenterology and Motility
• Print ISSN: 1350-1925
• Electronic ISSN: 1365-2982
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 30
• Issue: 9
• Article Number: e13400
• DOI: https://doi.org/10.1111/nmo.13400
• Keywords: ispaghula, laxative, relaxometry, MRI
• Public URL: https://nottingham-repository.worktribe.com/output/934270
• Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/nmo.13400
• Additional Information: This is the peer reviewed version of the following article: Major G, Murray K, Singh G, et al. Demonstration of differences in colonic volumes, transit, chyme consistency, and response to psyllium between healthy and constipated subjects using magnetic resonance ; imaging. Neurogastroenterol Motil. 2018;e13400. , which has been published in final form at https://onlinelibrary.wiley.com/doi/abs/10.1111/nmo.13400. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
• Contract Date: Jun 7, 2018