Outputs (106)

The placebo response rate in pharmacological trials in patients with irritable bowel syndrome: a systematic review and meta-analysis (2021)
Journal Article
Bosman, M., Elsenbruch, S., Corsetti, M., Tack, J., Simrén, M., Winkens, B., Boumans, T., Masclee, A., & Keszthelyi, D. (2021). The placebo response rate in pharmacological trials in patients with irritable bowel syndrome: a systematic review and meta-analysis. The Lancet Gastroenterology & Hepatology, 6(6), 459-473. https://doi.org/10.1016/S2468-1253%2821%2900023-6

Background
Clinical trials in irritable bowel syndrome are associated with high placebo response rates. We aimed to identify the magnitude of the placebo response and the contributing factors to this occurrence.

Methods
We did a systematic revie... Read More about The placebo response rate in pharmacological trials in patients with irritable bowel syndrome: a systematic review and meta-analysis.

Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review (2021)
Journal Article
Vinarov, Z., Abdallah, M., Agundez, J. A., Allegaert, K., Basit, A. W., Braeckmans, M., Ceulemans, J., Corsetti, M., Griffin, B. T., Grimm, M., Keszthelyi, D., Koziolek, M., Madla, C. M., Matthys, C., McCoubrey, L. E., Mitra, A., Reppas, C., Stappaerts, J., Steenackers, N., Trevaskis, N. L., …Augustijns, P. (2021). Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review. European Journal of Pharmaceutical Sciences, 162, Article 105812. https://doi.org/10.1016/j.ejps.2021.105812

The absorption of oral drugs is frequently plagued by significant variability with potentially serious therapeutic consequences. The source of variability can be traced back to interindividual variability in physiology, differences in special populat... Read More about Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review.

What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline? (2021)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Zhang, W., Doherty, M., Taal, M. W., Aithal, G. P., & Abhishek, A. (2021). What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?. Rheumatology, 60(12), 5785-5794. https://doi.org/10.1093/rheumatology/keab254

Objectives: To examine incidence of treatment changes due to abnormal blood-test results and, to explore rates of treatment changes due to liver, kidney and haematological blood-test abnormalities in autoimmune rheumatic diseases (AIRD) treated with... Read More about What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?.

Endoscopic management of Barrett’s dysplasia and early neoplasia: efficacy, safety and long-term outcomes in a UK tertiary centre (2021)
Journal Article
White, J. R., Ortiz-Fernández-Sordo, J., Santiago-García, J., Reddiar, D., Learoyd, A., De Caestecker, J., Cole, A., Kaye, P., & Ragunath, K. (2021). Endoscopic management of Barrett’s dysplasia and early neoplasia: efficacy, safety and long-term outcomes in a UK tertiary centre. European Journal of Gastroenterology and Hepatology, 33(1S Suppl 1), e413-e422. https://doi.org/10.1097/meg.0000000000002121

Background and Objectives: Endoscopic mucosal resection (EMR) and radiofrequency ablation (RFA) are effective treatments for dysplastic Barrett’s esophagus (BE). This study evaluates efficacy, durability and safety in a single high-volume UK tertiary... Read More about Endoscopic management of Barrett’s dysplasia and early neoplasia: efficacy, safety and long-term outcomes in a UK tertiary centre.

Faecal immunochemical testing and blood tests for prioritization of urgent colorectal cancer referrals in symptomatic patients: a 2-year evaluation (2021)
Journal Article
Bailey, J. A., Weller, J., Chapman, C., Ford, A., Hardy, K., Oliver, S., Morling, J. R., Simpson, J. A., Humes, D. J., & Banerjea, A. (2021). Faecal immunochemical testing and blood tests for prioritization of urgent colorectal cancer referrals in symptomatic patients: a 2-year evaluation. BJS Open, 5(2), Article zraa056. https://doi.org/10.1093/bjsopen/zraa056

Background
A novel pathway incorporating faecal immunochemical testing (FIT) for rapid colorectal cancer diagnosis (RCCD) was introduced in 2017. This paper reports on the service evaluation after 2 years of pathway implementation.

Methods
The R... Read More about Faecal immunochemical testing and blood tests for prioritization of urgent colorectal cancer referrals in symptomatic patients: a 2-year evaluation.

Bisacodyl: A review of pharmacology and clinical evidence to guide use in clinical practice in patients with constipation (2021)
Journal Article
Corsetti, M., Landes, S., & Lange, R. (2021). Bisacodyl: A review of pharmacology and clinical evidence to guide use in clinical practice in patients with constipation. Neurogastroenterology and Motility, 33(10), Article e14123. https://doi.org/10.1111/nmo.14123

Background: Bisacodyl is a member of the diphenylmethane family and is considered to be a stimulant laxative. It has a dual prokinetic and secretory action and needs to be converted into the active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (... Read More about Bisacodyl: A review of pharmacology and clinical evidence to guide use in clinical practice in patients with constipation.

Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS) Society Recommendations: Part 1—Preoperative: Diagnosis, Rapid Assessment and Optimization (2021)
Journal Article
Peden, C. J., Aggarwal, G., Aitken, R. J., Anderson, I. D., Bang Foss, N., Cooper, Z., Dhesi, J. K., French, W. B., Grant, M. C., Hammarqvist, F., Hare, S. P., Havens, J. M., Holena, D. N., Hübner, M., Kim, J. S., Lees, N. P., Ljungqvist, O., Lobo, D. N., Mohseni, S., Ordoñez, C. A., …Scott, M. (2021). Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS) Society Recommendations: Part 1—Preoperative: Diagnosis, Rapid Assessment and Optimization. World Journal of Surgery, 45, 1272–1290. https://doi.org/10.1007/s00268-021-05994-9

Background
Enhanced Recovery After Surgery (ERAS) protocols reduce length of stay, complications and costs fora large number of elective surgical procedures. A similar, structured approach appears to improve outcomes, including mortality, for patien... Read More about Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS) Society Recommendations: Part 1—Preoperative: Diagnosis, Rapid Assessment and Optimization.

Outcomes after non-operative management of perforated diverticular disease: a population-based cohort study (2021)
Journal Article
Adiamah, A., Ban, L., Otete, H., Crooks, C. J., West, J., & Humes, D. J. (2021). Outcomes after non-operative management of perforated diverticular disease: a population-based cohort study. BJS Open, 5(2), Article zraa073. https://doi.org/10.1093/bjsopen/zraa073

BACKGROUND: The management of perforated diverticular disease has changed in the past 10 years with a move towards less surgical intervention. This population-based cohort study aimed to define the risk of death and readmission following non-operativ... Read More about Outcomes after non-operative management of perforated diverticular disease: a population-based cohort study.

The Gut–Brain Axis and Its Role in Controlling Eating Behavior in Intestinal Inflammation (2021)
Journal Article
Moran, G. W., & Thapaliya, G. (2021). The Gut–Brain Axis and Its Role in Controlling Eating Behavior in Intestinal Inflammation. Nutrients, 13(3), Article 981. https://doi.org/10.3390/nu13030981

Malnutrition represents a major problem in the clinical management of the inflammatory
bowel disease (IBD). Presently, our understanding of the cross-link between eating behavior and
intestinal inflammation is still in its infancy. Crohn’s disease... Read More about The Gut–Brain Axis and Its Role in Controlling Eating Behavior in Intestinal Inflammation.

Pain severity correlates with biopsy mediated colonic afferent activation but not psychological scores in IBS-D patients (2021)
Journal Article
Cibert-Goton, V., Lam, C., Lingaya, M., Falcone, Y., Wood, J. N., Bulmer, D. C., & Spiller, R. (2021). Pain severity correlates with biopsy mediated colonic afferent activation but not psychological scores in IBS-D patients. Clinical and Translational Gastroenterology, 12(2), Article e00313. https://doi.org/10.14309/ctg.0000000000000313

Objectives: Despite heterogeneity an increased prevalence of psychological co-morbidity and an altered pro-nociceptive gut microenvironment have repeatedly emerged as causative pathophysiology in patients with irritable bowel syndrome(IBS). Our aim w... Read More about Pain severity correlates with biopsy mediated colonic afferent activation but not psychological scores in IBS-D patients.