Outputs (3)

Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling (2025)
Journal Article
Yang, Y., Hao, C., Jiao, T., Yang, Z., Li, H., Zhang, Y., Zhang, W., Doherty, M., Sun, C., Yang, T., Li, J., Wu, J., Zhang, M., Wang, Y., Xie, D., Wang, T., Wang, N., Huang, X., Li, C., Gonzalez, F. J., …Lei, G. (2025). Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling. Science, 388(6742), Article eadt0548. https://doi.org/10.1126/science.adt0548

The importance of central sensitization for clinical trials of Disease Modifying Osteoarthritis drugs (DMOADs) (2025)
Journal Article
Walsh, D. A., & McWilliams, D. F. (2025). The importance of central sensitization for clinical trials of Disease Modifying Osteoarthritis drugs (DMOADs). Osteoarthritis Imaging, 5(1), Article 100261. https://doi.org/10.1016/j.ostima.2025.100261

Osteoarthritis (OA) pain is associated with structural changes in the joint, which are usually quantified by imaging techniques. It is anticipated that structural disease modifying OA drugs (DMOADs) would reduce the burden of OA pain. However, nocice... Read More about The importance of central sensitization for clinical trials of Disease Modifying Osteoarthritis drugs (DMOADs).

Association of walking with incident knee osteoarthritis: a prospective cohort study using data from the UK Biobank (2025)
Journal Article
He, H., Wang, Y., Hunter, D., Zhang, Y., Zhang, W., Doherty, M., White, D. K., Wei, J., Zeng, C., & Lei, G. (2025). Association of walking with incident knee osteoarthritis: a prospective cohort study using data from the UK Biobank. Annals of the Rheumatic Diseases, 84(4), 632-642. https://doi.org/10.1016/j.ard.2025.01.019

Objectives: Walking offers numerous health benefits, yet its association with symptomatic knee osteoarthritis (SKOA) remains uncertain. The conflation of purposeful walking and unintentional walking could contribute to this uncertainty. Therefore, we... Read More about Association of walking with incident knee osteoarthritis: a prospective cohort study using data from the UK Biobank.