Outputs (37)

Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case–control study (2017)
Journal Article
Pearce, F. A., Hubbard, R. B., Grainge, M. J., Watts, R. A., Abhishek, A., & Lanyon, P. C. (2018). Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case–control study. QJM: An International Journal of Medicine, 111(1), 39-45. https://doi.org/10.1093/qjmed/hcx194

© The Author 2017. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. Background: People with granulomatosis with polyangiitis (GPA) commonly described long delays before diagnosis. Aim: To study the... Read More about Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case–control study.

Rheumatoid arthritis is getting less frequent—results of a nationwide population-based cohort study (2017)
Journal Article
Abhishek, A., Doherty, M., Kuo, C.-F., Mallen, C. D., Zhang, W., & Grainge, M. J. (2017). Rheumatoid arthritis is getting less frequent—results of a nationwide population-based cohort study. Rheumatology, 56(5), 736-744. https://doi.org/10.1093/rheumatology/kew468

Objectives: The objectives of this study were to examine changes in incidence and prevalence of RA between 1990 and 2014, and to explore if there is any geographic variation in incidence and prevalence of RA in the UK
Methods:
Design Prospective... Read More about Rheumatoid arthritis is getting less frequent—results of a nationwide population-based cohort study.

Familial aggregation and heritability of schizophrenia and co-aggregation of psychiatric illnesses in affected families (2016)
Journal Article
Chou, I.-J., Kuo, C.-F., Huang, Y.-S., Grainge, M. J., Valdes, A. M., See, L.-C., Yu, K.-H., Luo, S.-F., Huang, L.-S., Tseng, W.-Y., Zhang, W., & Doherty, M. (in press). Familial aggregation and heritability of schizophrenia and co-aggregation of psychiatric illnesses in affected families. Schizophrenia Bulletin, https://doi.org/10.1093/schbul/sbw159

Strong familial aggregation of schizophrenia has been reported but there is uncertainty concerning the degree of genetic contribution to the phenotypic variance of the disease. This study aimed to examine the familial aggregation and heritability of... Read More about Familial aggregation and heritability of schizophrenia and co-aggregation of psychiatric illnesses in affected families.

Early clinical features in Systemic Lupus Erythematosus: can they be used to achieve earlier diagnosis?: a risk prediction model (2016)
Journal Article
Rees, F., Doherty, M., Lanyon, P., Davenport, G., Riley, R. D., Zhang, W., & Grainge, M. J. (2017). Early clinical features in Systemic Lupus Erythematosus: can they be used to achieve earlier diagnosis?: a risk prediction model. Arthritis Care and Research, 69(6), 833-841. https://doi.org/10.1002/acr.23021

OBJECTIVES: 1) To compare the primary care consulting behaviour prior to diagnosis of people with Systemic Lupus Erythematosus (SLE) with controls, 2) to develop and validate a risk prediction model to aid earlier SLE diagnosis.

METHODS: 1,739 in... Read More about Early clinical features in Systemic Lupus Erythematosus: can they be used to achieve earlier diagnosis?: a risk prediction model.

Burden of comorbidity in systemic lupus erythematosus in the UK, 1999–2012 (2016)
Journal Article
Rees, F., Doherty, M., Grainge, M., Lanyon, P., Davenport, G., & Zhang, W. (in press). Burden of comorbidity in systemic lupus erythematosus in the UK, 1999–2012. Arthritis Care and Research, 68(6), https://doi.org/10.1002/acr.22751

Objective: To estimate the comorbidity associated with systemic lupus erythematosus (SLE) in the UK during 1999–2012.

Methods: A retrospective cohort study using the UK Clinical Practice Research Datalink was conducted. Prevalent cases of SLE wer... Read More about Burden of comorbidity in systemic lupus erythematosus in the UK, 1999–2012.

Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012 (2016)
Journal Article
Rees, F., Doherty, M., Grainge, M. J., Lanyon, P., Davenport, G., & Zhang, W. (2016). Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012. Rheumatology, 55(5), 854-860. https://doi.org/10.1093/rheumatology/kev424

OBJECTIVES: To estimate the mortality associated with SLE during the period 1999-2012 by age, gender and region; and to ascertain the cause of death for people with SLE.

METHODS: A retrospective cohort study using the UK Clinical Practice Research... Read More about Mortality in systemic lupus erythematosus in the United Kingdom 1999-2012.

Impact of gout on the risk of atrial fibrillation (2015)
Journal Article
Kuo, C.-F., Grainge, M. J., Mallen, C., Zhang, W., & Doherty, M. (2016). Impact of gout on the risk of atrial fibrillation. Rheumatology, 55(4), 721-728. https://doi.org/10.1093/rheumatology/kev418

OBJECTIVES: To examine the risk of atrial fibrillation (AF) at the time of first diagnosis of gout compared with matched controls and to follow incident gout patients and their matched controls after diagnosis to compare their subsequent risk of AF.... Read More about Impact of gout on the risk of atrial fibrillation.

Comorbidities in patients with gout prior to and following diagnosis: case-control study (2015)
Journal Article
Kuo, C.-F., Grainge, M. J., Mallen, C., Zhang, W., & Doherty, M. (2016). Comorbidities in patients with gout prior to and following diagnosis: case-control study. Annals of the Rheumatic Diseases, 75(1), https://doi.org/10.1136/annrheumdis-2014-206410

OBJECTIVES: To determine the burden of comorbidities in patients with gout at diagnosis and the risk of developing new comorbidities post diagnosis.

METHODS: There were 39 111 patients with incident gout and 39 111 matched controls identified fro... Read More about Comorbidities in patients with gout prior to and following diagnosis: case-control study.

Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families (2015)
Journal Article
Kuo, C.-F., Grainge, M. J., Valdes, A. M., See, L.-C., Luo, S.-F., Yu, K.-H., Zhang, W., & Doherty, M. (2015). Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families. JAMA Internal Medicine, 175(9), 1518-1526. https://doi.org/10.1001/jamainternmed.2015.3528

IMPORTANCE: Relatives of patients with systemic lupus erythematosus (SLE) appear to be at higher risk of SLE and other autoimmune diseases, but estimates of individual familial risks are largely unavailable or unreliable. Furthermore, relative contri... Read More about Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families.

Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score–matched landmark analysis (2015)
Journal Article
Kuo, C.-F., Grainge, M. J., Mallen, C., Zhang, W., & Doherty, M. (2015). Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score–matched landmark analysis. Rheumatology, 54(12), https://doi.org/10.1093/rheumatology/kev246

Objective: To examine the association between allopurinol use and all-cause mortality for patients with incident gout.

Methods: We compared all-cause mortality in incident gout patients who received allopurinol for at least 6 months within the exp... Read More about Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score–matched landmark analysis.