Outputs (795)

A cancer cell-specific inducer of apoptosis (2007)
Journal Article
Green, K. L., Brown, C., Roeder, G. E., Southgate, T. D., & Gaston, K. (2007). A cancer cell-specific inducer of apoptosis. Human Gene Therapy, 18(6), 547-561. https://doi.org/10.1089/hum.2006.042

Human papillomavirus (HPV) DNA is found in virtually all cervical cancers, strongly suggesting that these viruses are necessary to initiate this disease. The HPV E2 protein is required for viral replication, but E2 expression is usually lost in HPV-t... Read More about A cancer cell-specific inducer of apoptosis.

Characterization of an enhancer region of the galanin gene that directs expression to the dorsal root ganglion and confers responsiveness to axotomy (2007)
Journal Article
Bacon, A., Kerr, N. C., Holmes, F. E., Gaston, K., & Wynick, D. (2007). Characterization of an enhancer region of the galanin gene that directs expression to the dorsal root ganglion and confers responsiveness to axotomy. Journal of Neuroscience, 27(24), 6573-6580. https://doi.org/10.1523/JNEUROSCI.1596-07.2007

Galanin expression markedly increases in the dorsal root ganglion (DRG) after sciatic nerve axotomy and modulates pain behavior and regeneration of sensory neurons. Here, we describe transgenic mice expressing constructs with varying amounts of seque... Read More about Characterization of an enhancer region of the galanin gene that directs expression to the dorsal root ganglion and confers responsiveness to axotomy.

A quadrivalent vaccine for human papillomavirus (2006)
Journal Article
Brown, C., & Gaston, K. (2006). A quadrivalent vaccine for human papillomavirus. Drugs of today (Barcelona, Spain : 1998), 42(11), 703-709. https://doi.org/10.1358/dot.2006.42.11.1032056

Cervical cancer is responsible for at least 13,500 deaths a year in the European Union and more than 30 times that worldwide. DNA from a group of human papillomaviruses (HPVs) is found in virtually all cervical carcinoma cells, and these so-called hi... Read More about A quadrivalent vaccine for human papillomavirus.

Use of autoantibodies in breast cancer screening and diagnosis (2006)
Journal Article
Storr, S. J., Chakrabarti, J., Barnes, A., Murray, A., Chapman, C. J., & Robertson, J. F. (2006). Use of autoantibodies in breast cancer screening and diagnosis. Expert Review of Anticancer Therapy, 6(8), 1215-1223. https://doi.org/10.1586/14737140.6.8.1215

Breast cancer is the most common cancer among women and accounts for 6% of all cancer deaths. Current screening modalities for breast cancer diagnosis include mammography, digital mammography and magnetic resonance imaging; however, there is still an... Read More about Use of autoantibodies in breast cancer screening and diagnosis.

The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein (2006)
Journal Article
Hooley, E., Fairweather, V., Clarke, A. R., Gaston, K., & Brady, R. L. (2006). The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein. Nucleic Acids Research, 34(14), 3897-3908. https://doi.org/10.1093/nar/gkl466

The E2 proteins are transcription/replication factors from papillomaviruses. Human papillomaviruses (HPVs) can be broadly divided in two groups; low-risk HPV subtypes cause benign warts while high-risk HPVs give rise to cervical cancer. Although a ra... Read More about The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein.

E2 proteins from high- and low-risk human papillomavirus types differ in their ability to bind p53 and induce apoptotic cell death (2006)
Journal Article
Parish, J. L., Kowalczyk, A. M., Chen, H.-T., Roeder, G. E., Sessions, R. B., Buckle, M., & Gaston, K. L. (2006). E2 proteins from high- and low-risk human papillomavirus types differ in their ability to bind p53 and induce apoptotic cell death. Journal of Virology, 80(9), 4580-4590. https://doi.org/10.1128/JVI.80.9.4580-4590.2006

Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain (2006)
Journal Article
Soufi, A., Smith, C., Clarke, A. R., Gaston, K., & Jayaraman, P.-S. (2006). Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain. Journal of Molecular Biology, 358(4), 943-962. https://doi.org/10.1016/j.jmb.2006.02.020

Homeodomain proteins regulate multiple developmental pathways by altering gene expression temporally and in a tissue-specific fashion. The Proline Rich Homeodomain protein (PRH/Hex) is a transcription factor and an essential regulator of embryonic de... Read More about Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain.

Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy (2006)
Journal Article
Green, K. L., Southgate, T. D., Mulryan, K., Fairbairn, L. J., Stern, P. L., & Gaston, K. (2006). Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy. Human Gene Therapy, 17(2), 147-157. https://doi.org/10.1089/hum.2006.17.147

Human papillomaviruses (HPVs) are a causative agent of cervical cancer and are implicated in several other types of malignant disease including cancer of the vulva, oral cancer, and skin cancer. In HPV-transformed cells, expression of the viral E6 an... Read More about Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy.

Purification and characterisation of the PRH homeodomain: removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction (2006)
Journal Article
Soufi, A., Gaston, K., & Jayaraman, P.-S. (2006). Purification and characterisation of the PRH homeodomain: removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction. International Journal of Biological Macromolecules, 39(1-3), 45-50. https://doi.org/10.1016/j.ijbiomac.2006.01.004

The Proline-Rich Homeodomain (PRH) protein is a regulator of transcription and translation and plays a key role in the control of cell proliferation and cell differentiation. PRH contains an N-terminal proline-rich domain that can repress transcripti... Read More about Purification and characterisation of the PRH homeodomain: removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction.

Measuring the induction or inhibition of apoptosis by HPV proteins (2005)
Book Chapter
Kowalczyk, A. M., Roeder, G. E., Green, K., Stephens, D. J., & Gaston, K. (2005). Measuring the induction or inhibition of apoptosis by HPV proteins. In C. Davy, & J. Doorbar (Eds.), Human Papillomaviruses: methods and protocols (419 -- 432). Humana Press. https://doi.org/10.1385/1-59259-982-6%3A419

Many viral proteins influence the cellular pathways that control cell proliferation and cell death. Some viral proteins trigger apoptotic cell death, and this may be important in host defense and viral spread. In other cases, viral proteins inhibit a... Read More about Measuring the induction or inhibition of apoptosis by HPV proteins.