Outputs (795)

Expression of thioredoxin system and related peroxiredoxin proteins is associated with clinical outcome in radiotherapy treated early stage breast cancer (2011)
Journal Article
Woolston, C. M., Storr, S. J., Ellis, I. O., Morgan, D. A., & Martin, S. G. (2011). Expression of thioredoxin system and related peroxiredoxin proteins is associated with clinical outcome in radiotherapy treated early stage breast cancer. Radiotherapy and Oncology, 100(2), 308-313. https://doi.org/10.1016/j.radonc.2011.05.029

Background and purpose
Deregulated redox systems provide cancer cells protection from increased oxidative stress, such as that induced by ionizing radiation. Expression of the thioredoxin system proteins (thioredoxin, thioredoxin reductase and thior... Read More about Expression of thioredoxin system and related peroxiredoxin proteins is associated with clinical outcome in radiotherapy treated early stage breast cancer.

Calpastatin is associated with lymphovascular invasion in breast cancer (2011)
Journal Article
Storr, S. J., Mohammed, R. A., Woolston, C. M., Green, A. R., Parr, T., Spiteri, I., Caldas, C., Ball, G. R., Ellis, I. O., & Martin, S. G. (2011). Calpastatin is associated with lymphovascular invasion in breast cancer. Breast, 20(5), 413-418. https://doi.org/10.1016/j.breast.2011.04.002

Metastasis of breast cancer is a major contributor to mortality. Histological assessment of vascular invasion (VI) provides important prognostic information and demonstrates that VI occurs predominantly via lymphatics in breast cancer. We sought to e... Read More about Calpastatin is associated with lymphovascular invasion in breast cancer.

The calpain system and cancer (2011)
Journal Article
Storr, S. J., Carragher, N. O., Frame, M. C., Parr, T., & Martin, S. G. (2011). The calpain system and cancer. Nature Reviews Cancer, 11(5), 364-374. https://doi.org/10.1038/nrc3050

The calpains are a conserved family of cysteine proteinases that catalyse the controlled proteolysis of many specific substrates. Calpain activity is implicated in several fundamental physiological processes, including cytoskeletal remodelling, cellu... Read More about The calpain system and cancer.

Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy (2011)
Journal Article
Storr, S. J., Woolston, C. M., Barros, F. F., Green, A. R., Shehata, M., Chan, S. Y., Ellis, I. O., & Martin, S. G. (2011). Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy. International Journal of Cancer, 129(7), 1773-1780. https://doi.org/10.1002/ijc.25832

The calpain family, and their endogenous inhibitor calpastatin, has been implicated in cancer progression, and recent in vitro data have indicated a role in trastuzumab resistance. The aims of our study were to examine expression levels of calpastati... Read More about Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy.

Redox Protein Expression Predicts Radiotherapeutic Response in Early-Stage Invasive Breast Cancer Patients (2011)
Journal Article
Woolston, C. M., Al-Attar, A., Ellis, I. O., Storr, S. J., Morgan, D. A., & Martin, S. G. (2011). Redox Protein Expression Predicts Radiotherapeutic Response in Early-Stage Invasive Breast Cancer Patients. International Journal of Radiation Oncology - Biology - Physics, 79(5), 1532-1540. https://doi.org/10.1016/j.ijrobp.2010.11.002

Purpose

Early-stage invasive breast cancer patients have commonly undergone breast-conserving surgery and radiotherapy. In a large majority of these patients, the treatment is effective; however, a proportion will develop local recurrence. Deregul... Read More about Redox Protein Expression Predicts Radiotherapeutic Response in Early-Stage Invasive Breast Cancer Patients.

The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells (2010)
Journal Article
Grundy, M., Seedhouse, C., Shang, S., Richardson, J., Russell, N., & Pallis, M. (2010). The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells. Molecular Cancer Therapeutics, 9(3), https://doi.org/10.1158/1535-7163.MCT-09-1144

Aurora kinases play an essential role in orchestrating chromosome alignment, segregation, and cytokinesis during mitotic progression and both aurora-A and B are frequently overexpressed in a variety of human malignancies. In this study, we report the... Read More about The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells.

Protein flexibility directs DNA recognition by the papillomavirus E2 proteins (2010)
Journal Article
Brown, C. A., Campos-León, K., Strickland, M., Williams, C., Fairweather, V., Brady, R. L., Crump, M. P., & Gaston, K. (2011). Protein flexibility directs DNA recognition by the papillomavirus E2 proteins. Nucleic Acids Research, 39(7), 2969--2980. https://doi.org/10.1093/nar/gkq1217

Although DNA flexibility is known to play an important role in DNA–protein interactions, the importance of protein flexibility is less well understood. Here, we show that protein dynamics are important in DNA recognition using the well-characterized... Read More about Protein flexibility directs DNA recognition by the papillomavirus E2 proteins.

DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers (2010)
Journal Article
Soufi, A., Sawasdichai, A., Shukla, A., Noy, P., Dafforn, T., Smith, C., Jayaraman, P.-S., & Gaston, K. (2010). DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers. Nucleic Acids Research, 38(21), 7513--7525. https://doi.org/10.1093/nar/gkq659

Protein self-organization is essential for the establishment and maintenance of nuclear architecture and for the regulation of gene expression. We have shown previously that the Proline-Rich Homeodomain protein (PRH/Hex) self-assembles to form oligom... Read More about DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers.

In situ subcellular fractionation of adherent and non-adherent mammalian cells (2010)
Journal Article
Sawasdichai, A., Chen, H.-T., Abdul Hamid, N., Jayaraman, P.-S., & Gaston, K. (2010). In situ subcellular fractionation of adherent and non-adherent mammalian cells. Journal of Visualized Experiments, 41, Article e1958. https://doi.org/10.3791/1958

Protein function is intimately coupled to protein localization. Although some proteins are restricted to a specific location or subcellular compartment, many proteins are present as a freely diffusing population in free exchange with a sub-population... Read More about In situ subcellular fractionation of adherent and non-adherent mammalian cells.

PRH/Hex controls cell survival through coordinate transcriptional regulation of vascular endothelial growth factor signaling (2010)
Journal Article
Noy, P., Williams, H., Sawasdichai, A., Gaston, K., & Jayaraman, P.-S. (2010). PRH/Hex controls cell survival through coordinate transcriptional regulation of vascular endothelial growth factor signaling. Molecular and Cellular Biology, 30(9), 2120-2134. https://doi.org/10.1128/MCB.01511-09

The proline-rich homeodomain protein (PRH) plays multiple roles in the control of gene expression during embryonic development and in the adult. Vascular endothelial growth factor (VEGF) is a mitogen that stimulates cell proliferation and survival vi... Read More about PRH/Hex controls cell survival through coordinate transcriptional regulation of vascular endothelial growth factor signaling.