Outputs (795)

Characteristics and prognostic significance of polo-like kinase-1 (PLK1) expression in breast cancer (2023)
Journal Article
Lashen, A. G., Toss, M. S., Wootton, L., Green, A. R., Mongan, N. P., Madhusudan, S., & Rakha, E. (2023). Characteristics and prognostic significance of polo-like kinase-1 (PLK1) expression in breast cancer. Histopathology, 83(3), 414-425. https://doi.org/10.1111/his.14960

Background: Polo-like kinase-1 (PLK1) plays a crucial role in cell cycle progression,and it is considered a potential therapeutic target in many cancers. Although the role of PLK1 is well established in triple negative breast cancer (TNBC) as an onco... Read More about Characteristics and prognostic significance of polo-like kinase-1 (PLK1) expression in breast cancer.

High Inner Centromere Protein Expression Correlates with Aggressive Features and Predicts Poor Prognosis in Patients with Invasive Breast Cancer (2023)
Journal Article
Ibrahim, A., Miligy, I. M., Toss, M. S., Green, A. R., & Rakha, E. A. (2023). High Inner Centromere Protein Expression Correlates with Aggressive Features and Predicts Poor Prognosis in Patients with Invasive Breast Cancer. Pathobiology, 90(6), 377–388. https://doi.org/10.1159/000529628

Introduction: Inner centromere protein (INCENP) is a member of the chromosomal passenger complex (CPC) and plays a key role in mitosis and cell proliferation. This study aims to evaluate the clinical and prognostic significance of INCENP in invasive... Read More about High Inner Centromere Protein Expression Correlates with Aggressive Features and Predicts Poor Prognosis in Patients with Invasive Breast Cancer.

Combined proliferation and apoptosis index provides better risk stratification in breast cancer (2023)
Journal Article
Ibrahim, A., Toss, M. S., Atallah, N. M., Al Saleem, M., Green, A. R., & Rakha, E. A. (2023). Combined proliferation and apoptosis index provides better risk stratification in breast cancer. Histopathology, 82(7), 1029-1047. https://doi.org/10.1111/his.14887

Aims: Breast cancer (BC) risk stratification is critical for predicting behaviour and guiding management decision-making. Despite the well-established prognostic value of cellular proliferation in BC, the interplay between proliferation and apoptosis... Read More about Combined proliferation and apoptosis index provides better risk stratification in breast cancer.

Bendamustine plus rituximab for the treatment of Waldenström Macroglobulinaemia: patient outcomes and impact of bendamustine dosing (2023)
Journal Article
Arulogun, S. O., Brian, D., Goradia, H., Cooney, A., Menne, T., Koo, R., O’Neill, A. T., Vos, J. M., Pratt, G., Turner, D., Marshall, K., Manos, K., Anderson, C., Gavriatopoulou, M., Kyriakou, C., Kersten, M. J., Minnema, M. C., Koutoumanou, E., El-Sharkawi, D., Linton, K., …D’Sa, S. P. (2023). Bendamustine plus rituximab for the treatment of Waldenström Macroglobulinaemia: patient outcomes and impact of bendamustine dosing. American Journal of Hematology, 98(5), 750-759. https://doi.org/10.1002/ajh.26895

Bendamustine and rituximab (BR) therapy is commonly used in the treatment of Waldenström Macroglobulinaemia (WM). The impact dose of Bendamustine dose on response and survival outcomes is not well established, and the impact of its use in different t... Read More about Bendamustine plus rituximab for the treatment of Waldenström Macroglobulinaemia: patient outcomes and impact of bendamustine dosing.

Outcomes in grade 3B follicular lymphoma: an international study led by the Australasian Lymphoma Alliance (2023)
Journal Article
Barraclough, A., England, J. T., Villa, D., Wight, J., Hapgood, G., Conn, J., Doo, N. W., Li, E. W., Gilbertson, M., Shaw, B., Bishton, M. J., Saeed, M., Ratnasingam, S., Abeyakoon, C., Chong, G., Wai, S. H., Ku, M., Lee, H.-P., Fleming, K., Tam, C., …Hawkes, E. A. (2023). Outcomes in grade 3B follicular lymphoma: an international study led by the Australasian Lymphoma Alliance. Haematologica, 108(9), https://doi.org/10.3324/haematol.2022.281375

Grade (G) 3B follicular lymphoma (FL) is a rare FL subtype which exists on a histological continuum between ‘low-grade’ (Grade 1, 2 and 3A FL) and diffuse large B-cell lymphoma (DLBCL) appearing to share features with each. Clinical characteristics a... Read More about Outcomes in grade 3B follicular lymphoma: an international study led by the Australasian Lymphoma Alliance.

OptoRheo: Simultaneous in situ micro-mechanical sensing and 3D imaging of live cell cultures (2023)
Preprint / Working Paper
Mendonca, T., Lis-Slimak, K., Matheson, A. B., Smith, M. G., Anane-Adjei, A. B., Cavanagh, R., Paterson, L., Dalgarno, P. A., Alexander, C., Tassieri, M., Merry, C. L. R., & Wright, A. J. OptoRheo: Simultaneous in situ micro-mechanical sensing and 3D imaging of live cell cultures

Biomechanical cues from the extracellular matrix (ECM) are essential for directing many cellular processes, from normal development and repair, to disease progression. To better understand cell-matrix interactions, we have developed a new instrument... Read More about OptoRheo: Simultaneous in situ micro-mechanical sensing and 3D imaging of live cell cultures.

Haematology (2023)
Book Chapter
Richardson, R., & Ellis, R. (2023). Haematology. In General Medicine and Surgery: Medical student revision guide (59-81). (1). Scion Publishing

The clinical value of progesterone receptor expression in luminal breast cancer: A study of a large cohort with long-term follow-up (2023)
Journal Article
Lashen, A. G., Toss, M. S., Mongan, N. P., Green, A. R., & Rakha, E. A. (2023). The clinical value of progesterone receptor expression in luminal breast cancer: A study of a large cohort with long-term follow-up. Cancer, 129(8), 1183-1194. https://doi.org/10.1002/cncr.34655

Background: The routine assessment of progesterone receptor (PR) expression in breast cancer (BC) remains controversial. This study aimed to evaluate the role of PR expression in luminal BC, with emphasis on the definition of positivity and its progn... Read More about The clinical value of progesterone receptor expression in luminal breast cancer: A study of a large cohort with long-term follow-up.

Measuring reader fatigue in the interpretation of screening digital breast tomosynthesis (DBT) (2023)
Journal Article
Chen, Y., Sudin, E. S., Partridge, G. J. W., Taib, A. G., Darker, I. T., Phillips, P., James, J. J., Satchithananda, K., Sharma, N., & Michell, M. J. (2023). Measuring reader fatigue in the interpretation of screening digital breast tomosynthesis (DBT). British Journal of Radiology, 96(1143), Article 20220629. https://doi.org/10.1259/bjr.20220629

Objectives: The interpretation of digital breast tomosynthesis (DBT) screening examinations is a complex task for an already overstretched workforce which has the potential to increase pressure on readers leading to fatigue and patient safety issues.... Read More about Measuring reader fatigue in the interpretation of screening digital breast tomosynthesis (DBT).

Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer (2023)
Journal Article
Lothion-Roy, J., Haigh, D. B., Harris, A. E., Metzler, V. M., Alsaleem, M., Toss, M. S., Kariri, Y., Ntekim, A., Robinson, B. D., Khani, F., Gudas, L. J., Allegrucci, C., James, V. H., Madhusudan, S., Mather, M., Emes, R. D., Archer, N., Fray, R. G., Rakha, E., Jeyapalan, J. N., …Woodcock, C. L. (2023). Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer. Frontiers in Genetics, 13, Article 1096071. https://doi.org/10.3389/fgene.2022.1096071

N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification. These proteins, and the m6A modification, are... Read More about Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer.