Methods of Inducing Cell Death
(2000)
Other
Outputs (789)
The E2 proteins from high-risk and low-risk papillomaviruses differ in their ability to induce apoptotic cell death (2000)
Presentation / Conference
Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors (2000)
Journal Article
The human Surf-1 and Surf-2 genes are divergently transcribed and share a single bi-directional promoter. The addition of serum growth factors to serum-starved cells activates transcription in the Surf-1 direction, but has no effect on transcription... Read More about Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors.
The HPV 16 E2 protein induces p53-dependent apoptosis (2000)
Presentation / Conference
The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway (2000)
Journal Article
The human papillomavirus (HPV) E2 protein regulates viral gene expression and is also required for viral replication. HPV-transformed cells often contain chromosomally integrated copies of the HPV genome in which the viral E2 gene is disrupted. We ha... Read More about The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.
Magnesium ions enhance the transfer of Human Papillomavirus E2 protein from non-specific to specific binding sites (1999)
Journal Article
The human papillomavirus 16 E2 protein binds to four specific DNA sequences present within the HPV 16 genome and regulates viral gene expression and DNA replication. However, the E2 protein can also bind tightly to non-specific DNA sequences. Here, w... Read More about Magnesium ions enhance the transfer of Human Papillomavirus E2 protein from non-specific to specific binding sites.
Cellular transcirption factors regulate human papillomavirus type 16 gene expression by binding to a subset of the DNA sequences recognised by the viral E2 protein (1999)
Journal Article
Human papillomavirus type 16 (HPV-16) is a DNA tumour virus that has been implicated in the development of cervical cancer. The HPV-16 E2 protein binds to four sites that are present upstream of the viral P97 promoter and regulates transcription of t... Read More about Cellular transcirption factors regulate human papillomavirus type 16 gene expression by binding to a subset of the DNA sequences recognised by the viral E2 protein.
Disruption of the human papillomavirus type 16 E2 gene protects cervical carcinoma cells from E2F-induced apoptosis (1997)
Journal Article
Human papillomavirus type 16 (HPV-16) is a DNA tumour virus that has been implicated in the development of cervical cancer. In non-transformed HPV-infected cells, the HPV E2 protein regulates transcription of the viral E6 and E7 oncogenes. Malignant... Read More about Disruption of the human papillomavirus type 16 E2 gene protects cervical carcinoma cells from E2F-induced apoptosis.
A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors (1997)
Journal Article
The human Surf-1 and Surf-2 housekeeping genes are divergently transcribed and share a bi-directional, TATA-less promoter. Housekeeping promoters typically contain complex arrays of transcription factor binding sites and several studies have suggeste... Read More about A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors.
DNA binding and bending by the human papillomavirus type 16 E2 protein: recognition of an extended binding site (1997)
Journal Article
The human papillomavirus (HPV) 16 E2 protein (hE2) binds to four sites present upstream of the P97 promoter and regulates transcription of the viral E6 and E7 oncogenes. We have determined the relative binding constants for the interaction of the ful... Read More about DNA binding and bending by the human papillomavirus type 16 E2 protein: recognition of an extended binding site.