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Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasion (2016)
Journal Article
Gaston, K., Tsitsilianos, M., Wadey, K. S., & Jayaraman, P. (2016). Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasion. Cell and Bioscience, 6, doi:10.1186/s13578-016-0077-7

The Proline Rich Homeodomain protein (PRH), also known as Haematopoietically Expressed homeobox (HHEX), is an essential transcription factor in embryonic development and in the adult. The PRH protein forms oligomeric complexes that bind to tandemly r... Read More about Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasion.

Assessment of Minimal Residual Disease in Standard-Risk AML (2016)
Journal Article
Ivey, A., Hills, R. K., Simpson, M. A., Jovanovic, J. V., Gilkes, A., Grech, A., …Grimwade, D. (2016). Assessment of Minimal Residual Disease in Standard-Risk AML. New England Journal of Medicine, 374(5), 422-433. https://doi.org/10.1056/NEJMoa1507471

Background: Despite the molecular heterogeneity of standard-risk acute myeloid leukemia (AML), treatment decisions are based on a limited number of molecular genetic markers and morphology-based assessment of remission. Sensitive detection of a leuke... Read More about Assessment of Minimal Residual Disease in Standard-Risk AML.

RECQL4 helicase has oncogenic potential in sporadic breast cancers (2016)
Journal Article
Arora, A., Agarwal, D., Abdel-Fatah, T. M., Lu, H., Croteau, D. L., Moseley, P., …Madhusudan, S. (2016). RECQL4 helicase has oncogenic potential in sporadic breast cancers. Journal of Pathology, 238(4), 495-501. https://doi.org/10.1002/path.4681

RECQL4 helicase is a molecular motor that unwinds DNA, a process essential during DNA replication and DNA repair. Germ-line mutations in RECQL4 cause type II Rothmund–Thomson syndrome (RTS), characterized by a premature ageing phenotype and cancer pr... Read More about RECQL4 helicase has oncogenic potential in sporadic breast cancers.

Endocrine pancreas development and regeneration: noncanonical ideas from neural stem cell biology (2016)
Journal Article
Masjkur, J., Poser, S. W., Nikolakopoulou, P., Chrousos, G., McKay, R. D., Bornstein, S. R., …Androutsellis-Theotokis, A. (2016). Endocrine pancreas development and regeneration: noncanonical ideas from neural stem cell biology. Diabetes, 65(2), https://doi.org/10.2337/db15-1099

Loss of insulin-producing pancreatic islet β-cells is a hallmark of type 1 diabetes. Several experimental paradigms demonstrate that these cells can, in principle, be regenerated from multiple endogenous sources using signaling pathways that are also... Read More about Endocrine pancreas development and regeneration: noncanonical ideas from neural stem cell biology.

Bimodality of intratumor Ki67 expression is an independent prognostic factor of overall survival in patients with invasive breast carcinoma (2016)
Journal Article
Laurinavicius, A., Plancoulaine, B., Rasmusson, A., Besusparis, J., Augulis, R., Meskauskas, R., …Ellis, I. O. (2016). Bimodality of intratumor Ki67 expression is an independent prognostic factor of overall survival in patients with invasive breast carcinoma. Virchows Archiv, 468(4), 493-502. https://doi.org/10.1007/s00428-016-1907-z

Proliferative activity, assessed by Ki67 immunohistochemistry (IHC), is an established prognostic and predictive biomarker of breast cancer (BC). However, it remains under-utilized due to lack of standardized robust measurement methodologies and sign... Read More about Bimodality of intratumor Ki67 expression is an independent prognostic factor of overall survival in patients with invasive breast carcinoma.

The effects of stress on brain and adrenal stem cells (2016)
Journal Article
de Celis, M. F. R., Bornstein, S. R., Androutsellis-Theotokis, A., Andoniadou, C. L., Licinio, J., Wong, M., & Ehrhart-Bornstein, M. (in press). The effects of stress on brain and adrenal stem cells. Molecular Psychiatry, 21(5), https://doi.org/10.1038/mp.2015.230

The brain and adrenal are critical control centers that maintain body homeostasis under basal and stress conditions, and orchestrate the body’s response to stress. It is noteworthy that patients with stress-related disorders exhibit increased vulnera... Read More about The effects of stress on brain and adrenal stem cells.

Up-regulation of genes involved in the Insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link Polycystic Ovarian Syndrome and endometrial cancer (2016)
Journal Article
Shafiee, M. N., Seedhouse, C., Mongan, N., Chapman, C., Deen, S., Abu, J., & Atiomo, W. (2016). Up-regulation of genes involved in the Insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link Polycystic Ovarian Syndrome and endometrial cancer. Molecular and Cellular Endocrinology, 424, 94-101. https://doi.org/10.1016/j.mce.2016.01.019

BACKGROUND Endometrial cancer (EC) is the most common gynaecological cancer amongst women in the UK. Although previous studies have found that women with polycystic ovary syndrome (PCOS) have at least a three-fold increase in endometrial cancer (E... Read More about Up-regulation of genes involved in the Insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link Polycystic Ovarian Syndrome and endometrial cancer.

STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system? (2016)
Journal Article
Nikolakopoulou, P., Poser, S., Masjkur, J., Fernandez Rubin de Celis, M., Toutouna, L., Andoniadou, C., …Androutsellis-Theotokis, A. (2016). STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system?. Hormone and Metabolic Research, 48(2), https://doi.org/10.1055/s-0041-111699

The endocrine system involves communication among different tissues in distinct organs, including the pancreas and components of the Hypothalamic- Pituitary-Adrenal Axis. The molecular mechanisms underlying these complex interactions are a subject of... Read More about STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system?.