P. Nikolakopoulou
STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system?
Nikolakopoulou, P.; Poser, S.W.; Masjkur, J.; Fernandez Rubin de Celis, M.; Toutouna, L.; Andoniadou, C.L.; McKay, R.D.; Chrousos, G.; Ehrhart-Bornstein, M.; Bornstein, S.R.; Androutsellis-Theotokis, A.
Authors
S.W. Poser
J. Masjkur
M. Fernandez Rubin de Celis
L. Toutouna
C.L. Andoniadou
R.D. McKay
G. Chrousos
M. Ehrhart-Bornstein
S.R. Bornstein
A. Androutsellis-Theotokis
Abstract
The endocrine system involves communication among different tissues in distinct organs, including the pancreas and components of the Hypothalamic- Pituitary-Adrenal Axis. The molecular mechanisms underlying these complex interactions are a subject of intense study as they may hold clues for the progression and treatment of a variety of metabolic and degenerative diseases. A plethora of signaling pathways, activated by hormones and other endocrine factors have been implicated in this communication. Recent advances in the stem cell field introduce a new level of complexity: adult progenitor cells appear to utilize distinct signaling pathways than the more mature cells in the tissue they co-reside. It is therefore important to elucidate the signal transduction requirements of adult progenitor cells in addition to those of mature cells. Recent evidence suggests that a common non-canonical signaling pathway regulates adult progenitors in several different tissues, rendering it as a potentially valuable starting point to explore their biology. The STAT3- Ser/Hes3 Signaling Axis was first identified as a major regulator of neural stem cells and, subsequently, cancer stem cells. In the endocrine/neuroendocrine system, this pathway operates on several levels, regulating other types of plastic cells: (a) it regulates pancreatic islet cell function and insulin release; (b) insulin in turn activates the pathway in broadly distributed neural progenitors and possibly also hypothalamic tanycytes, cells with important roles in the control of the adrenal gland; (c) adrenal progenitors themselves operate this pathway. The STAT3-Ser/Hes3 Signaling Axis therefore deserves additional research in the context of endocrinology.
Citation
Nikolakopoulou, P., Poser, S., Masjkur, J., Fernandez Rubin de Celis, M., Toutouna, L., Andoniadou, C., McKay, R., Chrousos, G., Ehrhart-Bornstein, M., Bornstein, S., & Androutsellis-Theotokis, A. (2016). STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system?. Hormone and Metabolic Research, 48(2), https://doi.org/10.1055/s-0041-111699
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 16, 2015 |
Online Publication Date | Jan 19, 2016 |
Publication Date | Apr 30, 2016 |
Deposit Date | May 10, 2017 |
Journal | Hormone and Metabolic Research |
Print ISSN | 0018-5043 |
Electronic ISSN | 1439-4286 |
Publisher | Thieme Publishing |
Peer Reviewed | Peer Reviewed |
Volume | 48 |
Issue | 2 |
DOI | https://doi.org/10.1055/s-0041-111699 |
Keywords | STAT3, Hes3, stem cells |
Public URL | https://nottingham-repository.worktribe.com/output/783067 |
Publisher URL | https://doi.org/10.1055/s-0041-111699 |
Contract Date | May 10, 2017 |
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