Outputs (127)

Opioids and the risk of fracture: a self-controlled case series study in the Clinical Practice Research Datalink (2021)
Journal Article
Peach, E., Pearce, F., Gibson, J., Cooper, A., Chen, L.-C., & Knaggs, R. (2021). Opioids and the risk of fracture: a self-controlled case series study in the Clinical Practice Research Datalink. American Journal of Epidemiology, 190(7), 1324-1331. https://doi.org/10.1093/aje/kwab042

Self-controlled study designs can be used to assess the association between exposures and acute outcomes while controlling for important confounders. Using routinely collected health data, a self-controlled case series design was used to investigate... Read More about Opioids and the risk of fracture: a self-controlled case series study in the Clinical Practice Research Datalink.

The feasibility and tolerability of using Inspiratory Muscle Training (IMT) with adults discharged from the hospital with community-acquired pneumonia (CAP) (2021)
Journal Article
Pick, H., Faghy, M., Cresswell, G., Ashton, D., Bolton, C., McKeever, T., Lim, W., & Bewick, T. (2021). The feasibility and tolerability of using Inspiratory Muscle Training (IMT) with adults discharged from the hospital with community-acquired pneumonia (CAP). Advances in Respiratory Medicine, 89, 216-220. https://doi.org/10.5603/ARM.a2021.0002

Background: Patients experience substantial morbidity following discharge from hospital and during recovery from community-acquired pneumonia (CAP). Inspiratory muscle training (IMT) has demonstrated improved functional capacity and reduced patient-r... Read More about The feasibility and tolerability of using Inspiratory Muscle Training (IMT) with adults discharged from the hospital with community-acquired pneumonia (CAP).

How Quality Improvement Collaboratives Work to Improve Healthcare in Care Homes: A Realist Evaluation (2021)
Journal Article
Devi, R., Chadborn, N. H., Meyer, J., Banerjee, J., Goodman, C., Dening, T., Rf Gladman, J., Hinsliff-Smith, K., Long, A., Usman, A., Housley, G., Lewis, S., Glover, M., Gage, H., Logan, P. A., Martin, F. C., & Gordon, A. L. (2021). How Quality Improvement Collaboratives Work to Improve Healthcare in Care Homes: A Realist Evaluation. Age and Ageing, 50(4), 1371-1381. https://doi.org/10.1093/ageing/afab007

Background
Quality improvement collaboratives (QICs) bring together multidisciplinary teams in a structured process to improve care quality. How QICs can be used to support healthcare improvement in care homes is not fully understood.

Methods
A... Read More about How Quality Improvement Collaboratives Work to Improve Healthcare in Care Homes: A Realist Evaluation.

Decline in seasonal influenza vaccine effectiveness with vaccination program maturation: A systematic review and meta-analysis (2021)
Journal Article
Okoli, G. N., Racovitan, F., Abdulwahid, T., Hyder, S. K., Lansbury, L., Righolt, C. H., Mahmud, S. M., & Nguyen-Van-Tam, J. S. (2021). Decline in seasonal influenza vaccine effectiveness with vaccination program maturation: A systematic review and meta-analysis. Open Forum Infectious Diseases, 8(3), Article ofab069. https://doi.org/10.1093/ofid/ofab069

Objectives

Evidence suggests repeated influenza vaccination may reduce vaccine effectiveness (VE). Using influenza vaccination program maturation (number of years since program inception) [PM] as proxy for population-level repeated vaccination, we... Read More about Decline in seasonal influenza vaccine effectiveness with vaccination program maturation: A systematic review and meta-analysis.

Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus (2021)
Journal Article
Al-Beltagi, S., Preda, C. A., Goulding, L. V., James, J., Pu, J., Skinner, P., Jiang, M., Wang, B. L., Yang, J., Banyard, A. C., Mellits, K. H., Gershkovich, P., Hayes, C. J., Nguyen-Van-Tam, J., Brown, I. H., Liu, J., & Chang, K.-C. (2021). Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus. Viruses, 13(2), Article 234. https://doi.org/10.3390/v13020234

The long-term control strategy of SARS-CoV-2 and other major respiratory viruses needs to in-clude antivirals to treat acute infections, in addition to the judicious use of effective vaccines. Whilst COVID-19 vaccines are being rolled out for mass va... Read More about Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus.

Mortality rates immediately after severe hurricanes in Cuba have decreased over the past three decades (2021)
Journal Article
Suárez-Medina, R., Venero-Fernández, S., Mesa Ridel, G., Fogarty, A., & Lewis, S. (2021). Mortality rates immediately after severe hurricanes in Cuba have decreased over the past three decades. Public Health, 191, 55-58. https://doi.org/10.1016/j.puhe.2020.11.022

Objectives

The objective of this study is to understand how Cuba responds to extreme weather events, which can help identify and disseminate good public health practice.

Study design

The study design of this study is an observational study u... Read More about Mortality rates immediately after severe hurricanes in Cuba have decreased over the past three decades.

Health Risks of Kretek Cigarettes: A Systematic Review (2021)
Journal Article
Nuryunarsih, D., Lewis, S., & Langley, T. (2021). Health Risks of Kretek Cigarettes: A Systematic Review. Nicotine and Tobacco Research, 23(8), 1274–1282. https://doi.org/10.1093/ntr/ntab016

Objective To review the evidence on the health risks associated with smoking kretek cigarettes compared with not smoking or smoking regular cigarettes.

Data Sources: We conducted a systematic literature search in five electronic databases: EMBASE... Read More about Health Risks of Kretek Cigarettes: A Systematic Review.

Does advice based on biomarkers of liver injury or non-invasive tests of liver fibrosis impact high-risk drinking behaviour: A systematic review with meta-analysis (2021)
Journal Article
Subhani, M., Knight, H., Ryder, S., & Morling, J. R. (2021). Does advice based on biomarkers of liver injury or non-invasive tests of liver fibrosis impact high-risk drinking behaviour: A systematic review with meta-analysis. Alcohol and Alcoholism, 56(2), 185–200. https://doi.org/10.1093/alcalc/agaa143

Background: Alcohol dependence affects over 240 million people worldwide and attributed to 3 million deaths annually. Early identification and intervention are key to prevent harm. We aim to systematically review literature on the effectiveness of ad... Read More about Does advice based on biomarkers of liver injury or non-invasive tests of liver fibrosis impact high-risk drinking behaviour: A systematic review with meta-analysis.

Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia (2021)
Journal Article
Moreno, G., Rodríguez, A., Sole-Violán, J., Martín-Loeches, I., Díaz, E., Bodí, M., Reyes, L. F., Gómez, J., Guardiola, J., Trefler, S., Vidaur, L., Papiol, E., Socias, L., García-Vidal, C., Correig, E., Marín-Corral, J., Restrepo, M. I., Nguyen-Van-Tam, J. S., & Torres, A. (2021). Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia. ERJ Open Research, 7(1), Article 00888-2020. https://doi.org/10.1183/23120541.00888-2020

Background The relationship between early oseltamivir treatment (within 48 h of symptom onset) and mortality in patients admitted to intensive care units (ICUs) with severe influenza is disputed. This study aimed to investigate the association betwee... Read More about Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia.

Effect of stroke early supported discharge on length of hospital stay: analysis from a national stroke registry (2021)
Journal Article
Fisher, R. J., Byrne, A., Chouliara, N., Lewis, S., Paley, L., Hoffman, A., Rudd, A., Robinson, T., Langhorne, P., & Walker, M. (2021). Effect of stroke early supported discharge on length of hospital stay: analysis from a national stroke registry. BMJ Open, 11(1), Article e043480. https://doi.org/10.1136/bmjopen-2020-043480

Objective: The first observational study to investigate the impact of early supported discharge (ESD) on length of hospital stay in real-world conditions.

Design: Using historical prospective Sentinel Stroke National Audit Programme (SSNAP) data (... Read More about Effect of stroke early supported discharge on length of hospital stay: analysis from a national stroke registry.