Outputs (488)

Multicentre service evaluation of presentation of newly diagnosed cancers and type 1 diabetes in children in the UK during the COVID-19 pandemic (2021)
Journal Article
Williams, G., McLean, R., Liu, J. F., Ritzmann, T. A., Dandapani, M., Shanmugavadivel, D., Sachdev, P., Brougham, M., Mitchell, R. T., Conway, N. T., Law, J., Cunnington, A., Ogunnaike, G., Brougham, K., Bayman, E., & Walker, D. (2021). Multicentre service evaluation of presentation of newly diagnosed cancers and type 1 diabetes in children in the UK during the COVID-19 pandemic. BMJ Paediatrics Open, 5(1), Article e001078. https://doi.org/10.1136/bmjpo-2021-001078

Background The COVID-19 pandemic led to changes in patterns of presentation to emergency departments. Child health professionals were concerned that this could contribute to the delayed diagnosis of life-threatening conditions, including childhood ca... Read More about Multicentre service evaluation of presentation of newly diagnosed cancers and type 1 diabetes in children in the UK during the COVID-19 pandemic.

Impedimetric Characterization of Bipolar Nanoelectrodes with Cancer Cells (2021)
Journal Article
Robinson, A. J., Jain, A., Rahman, R., Abayzeed, S., Hague, R. J., & Rawson, F. J. (2021). Impedimetric Characterization of Bipolar Nanoelectrodes with Cancer Cells. ACS Omega, 6(44), 29495-29505. https://doi.org/10.1021/acsomega.1c03547

Merging of electronics with biology, defined as bioelectronics, at the nanoscale holds considerable promise for sensing and modulating cellular behavior. Advancing our understanding of nanobioelectronics will facilitate development and enable applica... Read More about Impedimetric Characterization of Bipolar Nanoelectrodes with Cancer Cells.

Anti-reflux medication use in preterm infants (2021)
Journal Article
Binti Abdul Hamid, H., Szatkowski, L., Budge, H., & Ojha, S. (2022). Anti-reflux medication use in preterm infants. Pediatric Research, 92, 520-525. https://doi.org/10.1038/s41390-021-01821-y

Background: Current recommendations do not support the use of anti-reflux medications to treat gastro-oesophageal reflux disease (GORD) among preterm infants. Objective: To describe the prevalence of GORD and the use of anti-reflux medications amongs... Read More about Anti-reflux medication use in preterm infants.

Paternal periconception metabolic health and offspring programming (2021)
Journal Article
Eid, N., Morgan, H. L., & Watkins, A. J. (2021). Paternal periconception metabolic health and offspring programming. Proceedings of the Nutrition Society, https://doi.org/10.1017/S0029665121003736

The association between maternal metabolic status at the time of conception and subsequent embryogenesis and offspring development has been studied in detail. However, less attention has been given to the significance of paternal nutrition and metabo... Read More about Paternal periconception metabolic health and offspring programming.

Treatment of COVID-19 in pregnant women: A systematic review and meta-analysis (2021)
Journal Article
Giesbers, S., Goh, E., Kew, T., Allotey, J., Brizuela, V., Kara, E., Kunst, H., Bonet, M., Thangaratinam, S., Chatterjee, S., Gae, A., Stallings, E., Yap, M., Sheikh, J., Lawson, H., Coomar, D., Dixit, A., Zhou, D., Balaji, R., Littmoden, M., …Mofenson, L. (2021). Treatment of COVID-19 in pregnant women: A systematic review and meta-analysis. European Journal of Obstetrics and Gynecology and Reproductive Biology, 267, 120-128. https://doi.org/10.1016/j.ejogrb.2021.10.007

Objective: Clinical trials evaluating pharmacological and non-pharmacological treatment of COVID-19, either excluded pregnant women or included very few women. Unlike the numerous systematic reviews on prevalence, symptoms and adverse outcomes of COV... Read More about Treatment of COVID-19 in pregnant women: A systematic review and meta-analysis.

Modifying the m6A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging (2021)
Journal Article
Martinez De La Cruz, B., Markus, R., Malla, S., Haig, M. I., Gell, C., Sang, F., Bellows, E., Sherif, M. A., McLean, D., Lourdusamy, A., Self, T., Bodi, Z., Smith, S., Fay, M., Macdonald, I. A., Fray, R., & Knight, H. M. (2021). Modifying the m6A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging. Molecular Psychiatry, 26(12), 7141-7153. https://doi.org/10.1038/s41380-021-01282-z

Synaptic plasticity processes, which underlie learning and memory formation, require RNA to be translated local to synapses. The synaptic tagging hypothesis has previously been proposed to explain how mRNAs are available at specific activated synapse... Read More about Modifying the m6A brain methylome by ALKBH5-mediated demethylation: a new contender for synaptic tagging.

Feasibility of Photodynamic Therapy for Glioblastoma with the Mitochondria-Targeted Photosensitizer Tetramethylrhodamine Methyl Ester (TMRM) (2021)
Journal Article
Vasilev, A., Sofi, R., Smith, S. J., Rahman, R., Teschemacher, A. G., & Kasparov, S. (2021). Feasibility of Photodynamic Therapy for Glioblastoma with the Mitochondria-Targeted Photosensitizer Tetramethylrhodamine Methyl Ester (TMRM). Biomedicines, 9(10), Article 1453. https://doi.org/10.3390/biomedicines9101453

One of the most challenging problems in the treatment of glioblastoma (GBM) is the highly infiltrative nature of the disease. Infiltrating cells that are non-resectable are left behind after debulking surgeries and become a source of regrowth and rec... Read More about Feasibility of Photodynamic Therapy for Glioblastoma with the Mitochondria-Targeted Photosensitizer Tetramethylrhodamine Methyl Ester (TMRM).

Use of pooled serum samples to assess herd disease status using commercially available ELISAs (2021)
Journal Article
Hernandez-Medrano, J. H., Fernando Espinosa-Castilloa, L., Rodrigueza, A. D., Gutierreza, C. G., & Wapenaar, W. (2021). Use of pooled serum samples to assess herd disease status using commercially available ELISAs. Tropical Animal Health and Production, 53(5), Article 507. https://doi.org/10.1007/s11250-021-02939-1

Pooled samples are used in veterinary and human medicine as a cost-effective approach to monitor disease prevalence. Nonetheless, there is limited information on the effect of pooling on test performance, and research is required to determine the app... Read More about Use of pooled serum samples to assess herd disease status using commercially available ELISAs.

A Systematic Review of the Biological Effects of Cordycepin (2021)
Journal Article
Radhi, M., Ashraf, S., Lawrence, S., Tranholm, A. A., Wellham, P. A. D., Hafeez, A., Khamis, A. S., Thomas, R., McWilliams, D., & De Moor, C. H. (2021). A Systematic Review of the Biological Effects of Cordycepin. Molecules, 26(19), Article 5886. https://doi.org/10.3390/molecules26195886

We conducted a systematic review of the literature on the effects of cordycepin on cell survival and proliferation, inflammation, signal transduction and animal models. A total of 1204 publications on cordycepin were found by the cut-off date of 1 Fe... Read More about A Systematic Review of the Biological Effects of Cordycepin.

Exploring the challenges of accessing medication for patients with cystic fibrosis (2021)
Journal Article
Herbert, S., Rowbotham, N., Smith, S., Wilson, P., Elliott, Z., Leighton, P., Duff, A., & Smyth, A. R. (2022). Exploring the challenges of accessing medication for patients with cystic fibrosis. Thorax, 77(3), 295-297. https://doi.org/10.1136/thoraxjnl-2021-217140

Reducing treatment burden in cystic fibrosis (CF) is the top research priority for patients and clinicians. Difficulty accessing medication is one aspect of treatment burden. We investigated this with an online survey available globally for patients... Read More about Exploring the challenges of accessing medication for patients with cystic fibrosis.