Outputs (488)

Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site (2022)
Journal Article
Muresan, P., McCrorie, P., Smith, F., Vasey, C., Taresco, V., Scurr, D. J., Kern, S., Smith, S., Gershkovich, P., Rahman, R., & Marlow, M. (2023). Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site. European Journal of Pharmaceutics and Biopharmaceutics, 182, 53-61. https://doi.org/10.1016/j.ejpb.2022.11.016

Systemic drug delivery to the central nervous system (CNS) has been historically impeded by the presence of the blood brain barrier rendering many therapies inefficacious to any cancer cells residing within the brain. Therefore, local drug delivery s... Read More about Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site.

Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers (2022)
Journal Article
Mehradnia, F., Moloney, C., Cavanagh, R., Pearce, A. K., Ritchie, A., Clarke, P., Rahman, R., Ibrahim, A., Grabowskab, A. M., & Alexander, C. (2022). Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers. British Journal of Pharmacy, 7(2), https://doi.org/10.5920/bjpharm.1173

The therapeutic efficacy of anticancer nanocarriers ishighly dependent on their size, shape, targeting ability, and stimuli-responsiveness. Herein, we studied the in vivo therapeutic efficacy ofDoxorubicin (Dox) loaded redox responsive micellar-like... Read More about Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers.

Standards of care for CFTR variant-specific therapy (including modulators) for people with cystic fibrosis (2022)
Journal Article
Southern, K. W., Castellani, C., Lammertyn, E., Smyth, A., VanDevanter, D., van Koningsbruggen-Rietschel, S., Barben, J., Bevan, A., Brokaar, E., Collins, S., Connett, G. J., Daniels, T. W., Davies, J., Declercq, D., Gartner, S., Gramegna, A., Hamilton, N., Hauser, J., Kashirskaya, N., Kessler, L., …Duff, A. (2023). Standards of care for CFTR variant-specific therapy (including modulators) for people with cystic fibrosis. Journal of Cystic Fibrosis, 22(1), 17-30. https://doi.org/10.1016/j.jcf.2022.10.002

Cystic fibrosis (CF) has entered the era of variant-specific therapy, tailored to the genetic variants in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. CFTR modulators, the first variant-specific therapy available, have transfo... Read More about Standards of care for CFTR variant-specific therapy (including modulators) for people with cystic fibrosis.

Electric field responsive nanotransducers for glioblastoma (2022)
Journal Article
Jain, A., Jobson, I., Griffin, M., Rahman, R., Smith, S., & Rawson, F. J. (2022). Electric field responsive nanotransducers for glioblastoma. Bioelectronic Medicine, 8(1), Article 17. https://doi.org/10.1186/s42234-022-00099-7

Background

Electric field therapies such as Tumor Treating Fields (TTFields) have emerged as a bioelectronic treatment for isocitrate dehydrogenase wild-type and IDH mutant grade 4 astrocytoma Glioblastoma (GBM). TTFields rely on alternating curre... Read More about Electric field responsive nanotransducers for glioblastoma.

Spatial transcriptomic analysis delineates epithelial and mesenchymal subpopulations and transition stages in childhood ependymoma (2022)
Journal Article
Fu, R., Norris, G. A., Willard, N., Griesinger, A. M., Riemondy, K. A., Amani, V., Grimaldo, E., Harris, F., Hankinson, T. C., Mitra, S., Ritzmann, T. A., Grundy, R. R., Foreman, N. K., & Donson, A. M. (2023). Spatial transcriptomic analysis delineates epithelial and mesenchymal subpopulations and transition stages in childhood ependymoma. Neuro-Oncology, 25(4), 786-798. https://doi.org/10.1093/neuonc/noac219

Background The diverse cellular constituents of childhood brain tumor ependymoma, recently revealed by single cell RNA-sequencing, may underly therapeutic resistance. Here we use spatial transcriptomics to further advance our understanding of the tum... Read More about Spatial transcriptomic analysis delineates epithelial and mesenchymal subpopulations and transition stages in childhood ependymoma.

Protocol for establishing a core outcome set for evaluation in studies of pulmonary exacerbations in people with cystic fibrosis (2022)
Journal Article
McLeod, C., Smyth, A. R., Messer, M., Schultz, A., Wood, J., Norman, R., Blyth, C. C., Webb, S., Elliott, Z., Van Devanter, D., Stephenson, A. L., Tong, A., & Snelling, T. L. (2022). Protocol for establishing a core outcome set for evaluation in studies of pulmonary exacerbations in people with cystic fibrosis. BMJ Open, 12(9), Article e056528. https://doi.org/10.1136/bmjopen-2021-056528

INTRODUCTION: Pulmonary exacerbations are associated with increased morbidity and mortality in people with cystic fibrosis (CF). There is no consensus about which outcomes should be evaluated in studies of pulmonary exacerbations or how these outcome... Read More about Protocol for establishing a core outcome set for evaluation in studies of pulmonary exacerbations in people with cystic fibrosis.

Parental Programming of Offspring Health: The Intricate Interplay between Diet, Environment, Reproduction and Development (2022)
Journal Article
Batra, V., Norman, E., Morgan, H. L., & Watkins, A. J. (2022). Parental Programming of Offspring Health: The Intricate Interplay between Diet, Environment, Reproduction and Development. Biomolecules, 12(9), Article 1289. https://doi.org/10.3390/biom12091289

As adults, our health can be influenced by a range of lifestyle and environmental factors, increasing the risk for developing a series of non-communicable diseases such as type 2 diabetes, heart disease and obesity. Over the past few decades, our und... Read More about Parental Programming of Offspring Health: The Intricate Interplay between Diet, Environment, Reproduction and Development.

Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland (2022)
Journal Article
Kwok, T. C., Dineen, R. A., Whitehouse, W., Lynn, R. M., McSweeney, N., & Sharkey, D. (2022). Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland. Open Medicine, 17(1), 1417-1424. https://doi.org/10.1515/med-2022-0554

Neonatal stroke is a devastating condition that causes brain injury in babies and often leads to lifelong neurological impairment. Recent prospective population studies of neonatal stroke are lacking. Neonatal strokes are different from those in olde... Read More about Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland.

Impact of Tumour Epstein–Barr Virus Status on Clinical Outcome in Patients with Classical Hodgkin Lymphoma (cHL): A Review of the Literature and Analysis of a Clinical Trial Cohort of Children with cHL (2022)
Journal Article
Nohtani, M., Vrzalikova, K., Ibrahim, M., Powell, J. E., Fennell, É., Morgan, S., Grundy, R., McCarthy, K., Dewberry, S., Bouchal, J., Bouchalova, K., Kearns, P., & Murray, P. G. (2022). Impact of Tumour Epstein–Barr Virus Status on Clinical Outcome in Patients with Classical Hodgkin Lymphoma (cHL): A Review of the Literature and Analysis of a Clinical Trial Cohort of Children with cHL. Cancers, 14(17), Article 4297. https://doi.org/10.3390/cancers14174297

In this study, we have re-evaluated how EBV status influences clinical outcome. To accomplish this, we performed a literature review of all studies that have reported the effect of EBV status on patient outcome and also explored the effect of EBV pos... Read More about Impact of Tumour Epstein–Barr Virus Status on Clinical Outcome in Patients with Classical Hodgkin Lymphoma (cHL): A Review of the Literature and Analysis of a Clinical Trial Cohort of Children with cHL.

Modelling Variations in Newborn Life Support Procedure Using Colored Petri Nets (2022)
Presentation / Conference Contribution
Leva, M. C., Patelli, E., Podofillini, L., Wilson, S., Tan, A., Remenyte-Prescott, R., Valstar, M., & Sharkey, D. (2022, August). Modelling Variations in Newborn Life Support Procedure Using Colored Petri Nets. Presented at 32nd European Safety and Reliability Conference (ESREL 2022), Dublin, Ireland

This research is conducted to study variations in the Newborn Life Support procedure. This procedure follows an evidence-based protocol to resuscitate and stabilize newborn babies requiring assistance at birth. Errors and ineffective actions in this... Read More about Modelling Variations in Newborn Life Support Procedure Using Colored Petri Nets.