Outputs (3)

Transcriptomic analysis of rat prefrontal cortex following chronic stress induced by social isolation – Relevance to psychiatric and neurodevelopmental illness, and implications for treatment (2024)
Journal Article
Goh, J.-Y., Rueda, P., Taylor, J., Rathbone, A., Scott, D., Langmead, C. J., Fone, K. C., Stewart, G. D., & King, M. V. (2024). Transcriptomic analysis of rat prefrontal cortex following chronic stress induced by social isolation – Relevance to psychiatric and neurodevelopmental illness, and implications for treatment. Neurobiology of Stress, 33, Article 100679. https://doi.org/10.1016/j.ynstr.2024.100679

Social isolation is an established risk factor for psychiatric illness, and became increasingly topical with the spread of SARS-CoV-2. We used RNA sequencing (RNA-Seq) to enable unbiased assessment of transcriptomic changes within the prefrontal cort... Read More about Transcriptomic analysis of rat prefrontal cortex following chronic stress induced by social isolation – Relevance to psychiatric and neurodevelopmental illness, and implications for treatment.

Determination of hATG8 Binding Selectivity of AIM (Autophagy-Interacting Motif) Peptides Using Native Electrospray Ionization Mass Spectrometry (2024)
Book Chapter
Brennan, A., Oldham, N., Layfield, R., & Scott, D. (2024). Determination of hATG8 Binding Selectivity of AIM (Autophagy-Interacting Motif) Peptides Using Native Electrospray Ionization Mass Spectrometry. In I. P. Nezis (Ed.), Selective autophagy: methods and protocols (237-246). Springer. https://doi.org/10.1007/978-1-0716-4067-8_19

Establishing the hATG8 binding selectivity of AIM (autophagy-interacting motif) sequences found within autophagy system proteins provides insights into their biological roles, and in the case of disease-associated AIM mutations, potential pathophysio... Read More about Determination of hATG8 Binding Selectivity of AIM (Autophagy-Interacting Motif) Peptides Using Native Electrospray Ionization Mass Spectrometry.

A convenient model of serum-induced reactivity of human astrocytes to investigate astrocyte-derived extracellular vesicles (2024)
Journal Article
White, K. E., Bailey, H. L., Shaw, B. S., Geiszler, P. C., Mesquita-Ribeiro, R., Scott, D., Layfield, R., & Serres, S. (2024). A convenient model of serum-induced reactivity of human astrocytes to investigate astrocyte-derived extracellular vesicles. Frontiers in Cellular Neuroscience, 18, Article 1414142. https://doi.org/10.3389/fncel.2024.1414142

Extracellular vesicles (EVs) are secreted by all cells in the CNS, including neurons and astrocytes. EVs are lipid membrane enclosed particles loaded with various bioactive cargoes reflecting the dynamic activities of cells of origin. In contrast to... Read More about A convenient model of serum-induced reactivity of human astrocytes to investigate astrocyte-derived extracellular vesicles.