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Outputs (7)

Microrheology of the cumulus-oocyte matrix using optical tweezers (2025)
Journal Article
Campugan, C., Perrella, C., Lim, M., Tan, T. C., Schartner, E., Arita, Y., Bruce, G. D., Mendonca, T., Wright, A., Dholakia, K., & Dunning, K. (2025). Microrheology of the cumulus-oocyte matrix using optical tweezers. Journal of Physics: Photonics, 7(2), Article 025008. https://doi.org/10.1088/2515-7647/adb360

Optical tweezers have emerged as a powerful, versatile approach for a range of studies in cellular and molecular biology. A particular highlight has been its use for microrheology measurements in miniscule sample volumes. In this study, we demonstrat... Read More about Microrheology of the cumulus-oocyte matrix using optical tweezers.

Hybrid photonic-plasmonic platform for high-throughput single-molecule studies (2019)
Journal Article
Mossayebi, M., Parini, A., Wright, A. J., Somekh, M. G., Bellanca, G., & Larkins, E. C. (2019). Hybrid photonic-plasmonic platform for high-throughput single-molecule studies. Optical Materials Express, 9(6), 2511-2522. https://doi.org/10.1364/OME.9.002511

We present the design and numerical characterization of a hybrid photonic-plasmonic nanoresonator comprised of a 2D photonic crystal (PhC) cavity, a gold bowtie nanoantenna (BNA) and a silicon dioxide, SiO2, spacer. This device is designed to serve a... Read More about Hybrid photonic-plasmonic platform for high-throughput single-molecule studies.

A minimally invasive optical trapping system to understand cellular interactions at onset of an immune response (2017)
Journal Article
Glass, D. G., McAlinden, N., Millington, O. R., & Wright, A. J. (2017). A minimally invasive optical trapping system to understand cellular interactions at onset of an immune response. PLoS ONE, 12(12), Article e0188581. https://doi.org/10.1371/journal.pone.0188581

T-cells and antigen presenting cells are an essential part of the adaptive immune response system and how they interact is crucial in how the body effectively fights infection or responds to vaccines. Much of the experimental work studying interactio... Read More about A minimally invasive optical trapping system to understand cellular interactions at onset of an immune response.

Surface-enhanced Raman scattering measurement from a lipid bilayer encapsulating a single decahedral nanoparticle mediated by an optical trap (2016)
Journal Article
Wright, A. J., Richens, J. L., Bramble, J., Cathcart, N., Kitaev, V., O'Shea, P., & Hudson, A. (in press). Surface-enhanced Raman scattering measurement from a lipid bilayer encapsulating a single decahedral nanoparticle mediated by an optical trap. Nanoscale, 8(36), https://doi.org/10.1039/C6NR05616D

We present a new technique for the study of model membranes on the length-scale of a single nanosized liposome. Silver decahedral nanoparticles have been encapsulated by a model unilamellar lipid bilayer creating nano-sized lipid vesicles. The metal... Read More about Surface-enhanced Raman scattering measurement from a lipid bilayer encapsulating a single decahedral nanoparticle mediated by an optical trap.

Accurate position tracking of optically trapped live cells (2014)
Journal Article
McAlinden, N., Glass, D. G., Millington, O. R., & Wright, A. J. (2014). Accurate position tracking of optically trapped live cells. Biomedical Optics Express, 5(4), https://doi.org/10.1364/BOE.5.001026

Optical trapping is a powerful tool in Life Science research and is becoming common place in many microscopy laboratories and facilities. There is a growing need to directly trap the cells of interest rather than introduce beads to the sample that ca... Read More about Accurate position tracking of optically trapped live cells.

Strategies to overcome photobleaching in algorithm-based adaptive optics for nonlinearin-vivoimaging (2014)
Journal Article
Müllenbroich, M. C., McGhee, E. J., Wright, A. J., Anderson, K. I., & Mathieson, K. (2014). Strategies to overcome photobleaching in algorithm-based adaptive optics for nonlinearin-vivoimaging. Journal of Biomedical Optics, 19(1), Article 016021. https://doi.org/10.1117/1.JBO.19.1.016021

We have developed a nonlinear adaptive optics microscope utilizing a deformable membrane mirror (DMM) and demonstrated its use in compensating for system- and sample-induced aberrations. The optimum shape of the DMM was determined with a random searc... Read More about Strategies to overcome photobleaching in algorithm-based adaptive optics for nonlinearin-vivoimaging.