Outputs (2)

Microbial Primer: Agr-mediated quorum sensing in Gram-positive pathogens (2025)
Journal Article
Williams, P. (2025). Microbial Primer: Agr-mediated quorum sensing in Gram-positive pathogens. Microbiology, 171(7), Article 001590. https://doi.org/10.1099/mic.0.001590

Gram-positive bacteria commonly employ autoinducing peptide (AIP) signal molecules to co-ordinate gene expression at the population level. This primer provides a basic overview of agr-dependent quorum sensing systems and outlines how AIPs are produce... Read More about Microbial Primer: Agr-mediated quorum sensing in Gram-positive pathogens.

Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication (2025)
Journal Article
Romero, M., Luckett, J., Dubern, J.-F., Figueredo, G. P., Ison, E., Carabelli, A. M., Scurr, D. J., Hook, A. L., Kammerling, L., Da Silva, A. C., Xue, X., Blackburn, C., Carlier, A., Vasilevich, A., Sudarsanam, P. K., Vermeulen, S., Winkler, D. A., Ghaemmaghami, A. M., De Boer, J., Alexander, M. R., & Williams, P. (2025). Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication. Nature Communications, 16(1), Article 5295. https://doi.org/10.1038/s41467-025-60567-x

Bio-instructive materials that intrinsically inhibit biofilm formation have significant anti-biofouling potential in industrial and healthcare settings. Since bacterial surface attachment is sensitive to surface topography, we experimentally surveyed... Read More about Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication.