Professor PETER MERTENS's Outputs (31)

Comparative neuropathology of major Indian Bluetongue virus serotypes in a neonatal BALB/c mouse model (2018)
Journal Article
Anjaneya, A., Singh, K., Cherian, S., Saminathan, M., Singh, R., Ramakrishnan, M., Maan, S., Maan, N., Hemadri, D., Rao, P., Putty, K., Krishnajyothi, Y., & Mertens, P. (2018). Comparative neuropathology of major Indian Bluetongue virus serotypes in a neonatal BALB/c mouse model. Journal of Comparative Pathology, 162, 18-28. https://doi.org/10.1016/j.jcpa.2018.06.001

Bluetongue virus (BTV) is neurotropic in nature, especially in ruminant fetuses and in-utero infection results in abortion and congenital brain malformations. The aim of the present study was to compare the neuropathogenicity of major Indian BTV sero... Read More about Comparative neuropathology of major Indian Bluetongue virus serotypes in a neonatal BALB/c mouse model.

The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host (2018)
Journal Article
Calvo-Pinilla, E., Gubbins, S., Mertens, P. P., Ortego, J., & Castillo-Olivares, J. (2018). The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host. Antiviral Research, 154, https://doi.org/10.1016/j.antiviral.2018.04.015

African horse sickness (AHS) is a lethal equine disease transmitted by Culicoides biting midges and caused by African horse sickness virus (AHSV). AHS is endemic to sub-Saharan Africa, but devastating outbreaks have been recorded periodically outside... Read More about The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host.

Isolation and evolutionary analysis of Australasian topotype of bluetongue virus serotype 4 from India (2017)
Journal Article
Reddy, Y. V., Susmitha, B., Patil, S., Krishnajyothi, Y., Putty, K., Ramakrishna, K., Sunitha, G., Devi, B., Kavitha, K., Deepthi, B., Krovvidi, S., Reddy, Y., Reddy, G. H., Singh, K., Maan, N. S., Hemadri, D., Maan, S., Mertens, P., Hegde, N., & Rao, P. (in press). Isolation and evolutionary analysis of Australasian topotype of bluetongue virus serotype 4 from India. Transboundary and Emerging Diseases, https://doi.org/10.1111/tbed.12738

Bluetongue (BT) is a Culicoides-borne disease caused by several serotypes of bluetongue virus (BTV). Similar to other insect-borne viral diseases, distribution of BT is limited to distribution of Culicoides species competent to transmit BTV. In the t... Read More about Isolation and evolutionary analysis of Australasian topotype of bluetongue virus serotype 4 from India.

Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference (2017)
Journal Article
Jacquot, M., Nomikou, K., Palmarini, M., Mertens, P., & Biek, R. (2017). Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference. Proceedings of the Royal Society B: Biological Sciences, 284(1864), Article 20170919. https://doi.org/10.1098/rspb.2017.0919

Spatio-temporal patterns of the spread of infectious diseases are commonly driven by environmental and ecological factors. This is particularly true for vector-borne diseases because vector populations can be strongly affected by host distribution as... Read More about Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference.

How often do mosquitoes bite humans in southern England?: a standardised summer trial at four sites reveals spatial, temporal and site-related variation in biting rates (2017)
Journal Article
Brugman, V. A., England, M. E., Stoner, J., Tugwell, L., Harrup, L. E., Wilson, A. J., Medlock, J. M., Logan, J. G., Fooks, A. R., Mertens, P. P., Johnson, N., & Carpenter, S. (2017). How often do mosquitoes bite humans in southern England?: a standardised summer trial at four sites reveals spatial, temporal and site-related variation in biting rates. Parasites and Vectors, 10(1), Article 420. https://doi.org/10.1186/s13071-017-2360-9

Background

This field-based study examined the abundance and species complement of mosquitoes (Diptera: Culicidae) attracted to humans at four sites in the United Kingdom (UK). The study used a systematic approach to directly measure feeding by mo... Read More about How often do mosquitoes bite humans in southern England?: a standardised summer trial at four sites reveals spatial, temporal and site-related variation in biting rates.

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): bluetongue (2017)
Journal Article
More, S., Bicout, D., Bøtner, A., Butterworth, A., Depner, K., Edwards, S., Garin-Bastuji, B., Good, M., Gortázar Schmidt, C., Michel, V., Angel Miranda, M., Nielsen, S. S., Raj, M., Sihvonen, L., Spoolder, H., Arend Stegeman, J., Thulke, H.-H., Velarde, A., Willeberg, P., Winckler, C., …Calistri, P. (in press). Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): bluetongue. EFSA Journal, 15(8), https://doi.org/10.2903/j.efsa.2017.4957

A specific concept of strain was developed in order to classify the BTV serotypes ever reported in Europe based on their properties of animal health impact: the genotype, morbidity, mortality, speed of spread, period and geographical area of occurren... Read More about Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): bluetongue.

Concurrent infection of bluetongue and peste-des-petits-ruminants virus in small ruminants in Haryana State of India (2017)
Journal Article
Maan, S., Kumar, A., Gupta, A. K., Dalal, A., Chaudhary, D., Gupta, T. K., Bansal, N., Kumar, V., Batra, K., Sindhu, N., Kumar, A., Mahajan, N. K., Maan, N. S., & Mertens, P. P. (2018). Concurrent infection of bluetongue and peste-des-petits-ruminants virus in small ruminants in Haryana State of India. Transboundary and Emerging Diseases, 65(1), 235-239. https://doi.org/10.1111/tbed.12610

Bluetongue (BT) and peste-des-petits-ruminants (PPR) are major transboundary diseases of small ruminant, which are endemic in India. Testing of bluetongue virus (BTV) and peste-des-petits-ruminants virus (PPRV) from recent outbreaks (2015–2016) in di... Read More about Concurrent infection of bluetongue and peste-des-petits-ruminants virus in small ruminants in Haryana State of India.

Dual infection with bluetongue virus serotypes and first time detection of serotype 5 in India (2016)
Journal Article
Hemadri, D., Maan, S., Rao, P. N., Putty, K., Krishnajyothi, Y., Reddy, G. H., Kumar, V., Batra, K., Reddy, Y. V., Maan, N. S., Reddy, Y. N., Singh, K. P., Shivachandra, S. B., Hegde, N., Rahman, H., & Mertens, P. P. (2017). Dual infection with bluetongue virus serotypes and first time detection of serotype 5 in India. Transboundary and Emerging Diseases, 64(6), 1912-1917. https://doi.org/10.1111/tbed.12589

Bluetongue is endemic in India and has been reported from most Indian states. Of late, the clinical disease is most frequently seen in the states of Andhra Pradesh, Telangana (erstwhile Andhra Pradesh state), Tamil Nadu and Karnataka. Our analysis o... Read More about Dual infection with bluetongue virus serotypes and first time detection of serotype 5 in India.

Genome sequence of Bluetongue virus serotype 17 isolated in Brazil in 2014 (2016)
Journal Article
Matos, A. C. D., Rosa, J. C. C., Nomikou, K., Guimarães, L. L. B., Costa, É. A., Guedes, M. I. M. C., Driemeier, D., Lobato, Z. I. P., & Mertens, P. P. (in press). Genome sequence of Bluetongue virus serotype 17 isolated in Brazil in 2014. Genome Announcements, 4(5), Article e01161. https://doi.org/10.1128/genomeA.01161-16

The complete genome sequence of Bluetongue virus (BTV) serotype 17 strain 17/BRA/2014/73, isolated from a sheep in Brazil in 2014, is reported here. All segments clustered with western topotype strains and indicated reassortment events with other BTV... Read More about Genome sequence of Bluetongue virus serotype 17 isolated in Brazil in 2014.

Development and evaluation of real time RT-PCR assays for detection and typing of Bluetongue virus (2016)
Journal Article
Richard, Y., Maan, S., Maan, N. S., Belaganahalli, M. N., Potgieter, A. C., Kumar, V., Batra, K., Wright, I. M., Kirkland, P. D., & Mertens, P. P. (2016). Development and evaluation of real time RT-PCR assays for detection and typing of Bluetongue virus. PLoS ONE, 11(9), Article e0163014. https://doi.org/10.1371/journal.pone.0163014

Bluetongue virus is the type species of the genus Orbivirus, family Reoviridae. Bluetongue viruses (BTV) are transmitted between their vertebrate hosts primarily by biting midges (Culicoides spp.) in which they also replicate. Consequently BTV distri... Read More about Development and evaluation of real time RT-PCR assays for detection and typing of Bluetongue virus.

Using combined diagnostic test results to hindcast trends of infection from cross-sectional data (2016)
Journal Article
Rydevik, G., Innocent, G. T., Marion, G., Davidson, R. S., White, P. C., Billinis, C., Barrow, P., Mertens, P. P., Gavier-Widén, D., & Hutchings, M. R. (2016). Using combined diagnostic test results to hindcast trends of infection from cross-sectional data. PLoS Computational Biology, 12(7), 1-19. https://doi.org/10.1371/journal.pcbi.1004901

Infectious disease surveillance is key to limiting the consequences from infectious pathogens and maintaining animal and public health. Following the detection of a disease outbreak, a response in proportion to the severity of the outbreak is require... Read More about Using combined diagnostic test results to hindcast trends of infection from cross-sectional data.