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Dr TRACY FARR's Outputs (4)

Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment (2014)
Journal Article
Füchtemeier, M., Brinckmann, M. P., Foddis, M., Kunz, A., Po, C., Curato, C., Dirnagl, U., & Farr, T. D. (2015). Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment. Journal of Cerebral Blood Flow and Metabolism, 35(3), https://doi.org/10.1038/jcbfm.2014.221

Our aims were to assess the spatiotemporal development of brain pathology in a mouse model of chronic hypoperfusion using magnetic resonance imaging (MRI), and to test whether the renin-angiotensin system (RAS) can offer therapeutic benefit. For the... Read More about Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment.

DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests (2014)
Journal Article
López-Gil, X., Amat-Roldan, I., Tudela, R., Castańé, A., Prats-Galino, A., Planas, A. M., Farr, T. D., & Soria, G. (2014). DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests. Frontiers in Aging Neuroscience, 6, Article 167. https://doi.org/10.3389/fnagi.2014.00167

The identification of biomarkers of vascular cognitive impairment is urgent for its early diagnosis. The aim of this study was to detect and monitor changes in brain structure and connectivity, and to correlate them with the decline in executive func... Read More about DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests.

Bioluminescence imaging of stroke-induced endogenous neural stem cell response (2014)
Journal Article
Vandeputte, C., Reumers, V., Aelvoet, S.-A., Thiry, I., De Swaef, S., Van den Haute, C., Pascual-Brazo, J., Farr, T. D., Vande Velde, G., Hoehn, M., Himmelreich, U., Van Laere, K., Debyser, Z., Gijsbers, R., & Baekelandt, V. (2014). Bioluminescence imaging of stroke-induced endogenous neural stem cell response. Neurobiology of Disease, 69, https://doi.org/10.1016/j.nbd.2014.05.014

Brain injury following stroke affects neurogenesis in the adult mammalian brain. However, a complete under¬standing of the origin and fate of the endogenous neural stem cells (eNSCs) in vivo is missing. Tools and technol¬ogy that allow non-invasive i... Read More about Bioluminescence imaging of stroke-induced endogenous neural stem cell response.

Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin (2014)
Journal Article
Farr, T. D., Lai, C.-H., Grünstein, D., Orts-Gil, G., Wang, C.-C., Boehm-Sturm, P., Seeberger, P. H., & Harms, C. (2014). Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin. Nano Letters, 14(4), https://doi.org/10.1021/nl500388h

Activation of the endothelium is a pivotal first step for leukocyte migration into the diseased brain. Consequently, imaging this activation process is highly desirable. We synthesized carbohydrate-functionalized magnetic nanoparticles that bind spec... Read More about Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin.