Dr RACHEL CLIFFORD's Outputs (5)

P238 Investigating genome wide dna methylation in airway smooth muscle cells from asthmatic and non-asthmatic donors (2016)
Presentation / Conference Contribution
Clifford, R. L., Patel, J., Shaw, D., Knox, A., & Kobor, M. P238 Investigating genome wide dna methylation in airway smooth muscle cells from asthmatic and non-asthmatic donors

Rationale: Genetic mechanisms fail to fully explain asthma pathogenesis and environmental factors are considered to play an important role. Environmental factors may lead to permanent changes in epigenetic patterns and contribute to asthma. Epigeneti... Read More about P238 Investigating genome wide dna methylation in airway smooth muscle cells from asthmatic and non-asthmatic donors.

The role of histone arginine methylation in gene expression of airway smooth muscle cells in asthma (2016)
Journal Article
Kaczmarek, K., Clifford, R. L., Patel, J., Shaw, D., Dowden, J., & Knox, A. (2016). The role of histone arginine methylation in gene expression of airway smooth muscle cells in asthma. Thorax, 71(Suppl3), A214-A215. https://doi.org/10.1136/thoraxjnl-2016-209333.379

Introduction and objectives: Asthma is estimated to affect at least 300 million people globally. About 25% of the patients do not respond to therapy; therefore we need to develop novel treatments. ASM cells have a crucial role in asthma, contributing... Read More about The role of histone arginine methylation in gene expression of airway smooth muscle cells in asthma.

S133 Investigating genome wide dna methylation in airway and parenchymal fibroblasts from healthy individuals and individuals with copd (2016)
Presentation / Conference Contribution
Clifford, R. L., Fishbane, N., Rajasekar, P., Fisher, A., Kobor, M., Knox, A., & Hackett, T. S133 Investigating genome wide dna methylation in airway and parenchymal fibroblasts from healthy individuals and individuals with copd

Rationale: Lung fibroblasts are implicated in respiratory disease pathology including chronic obstructive pulmonary disease (COPD). Phenotypic differences between fibroblasts isolated from the airway versus the parenchyma have been described but no s... Read More about S133 Investigating genome wide dna methylation in airway and parenchymal fibroblasts from healthy individuals and individuals with copd.

Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis (2016)
Journal Article
Porte, J., Tatler, A. L., Jenkins, G., Goodwin, A. T., Clifford, R., Gbolahan, O., Saini, G., John, A. E., Violette, S. M., Weinreb, P. H., Parfrey, H., Wolters, P. J., Gauldie, J., & Kolb, M. (2016). Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis. PLoS ONE, 11(8), 1-19. https://doi.org/10.1371/journal.pone.0158047

© 2016 Tatler et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cre... Read More about Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis.

Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation (2016)
Journal Article
Clifford, R. L., Jones, M. J., MacIsaac, J. L., McEwen, L. M., Goodman, S. J., Mostafavi, S., Kobor, M. S., & Carlsten, C. (2017). Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation. Journal of Allergy and Clinical Immunology, 139(1), https://doi.org/10.1016/j.jaci.2016.03.046

Background

Allergic disease affects 30% to 40% of the world's population, and its development is determined by the interplay between environmental and inherited factors. Air pollution, primarily consisting of diesel exhaust emissions, has increase... Read More about Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation.