Dr ABDOLRAHMAN SHAMS-NATERI's Outputs (29)

STAT3 paradoxically stimulates ??catenin expression but inhibits ??catenin function (2014)
Journal Article
Ibrahem, S., Al‐Ghamdi, S., Baloch, K., Muhammad, B., Fadhil, W., Jackson, D., Nateri, A., & Ilyas, M. (2014). STAT3 paradoxically stimulates β‐catenin expression but inhibits β‐catenin function. International Journal of Experimental Pathology, 95(6), 392-400. https://doi.org/10.1111/iep.12102

Wnt signalling and the signal transducer and activator of transcription 3 (STAT3) are oncogenic signalling pathways which are deregulated in colorectal cancer (CRC). Here we investigated the interaction of these two pathways. Firstly, we investigated... Read More about STAT3 paradoxically stimulates ??catenin expression but inhibits ??catenin function.

Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms (2012)
Journal Article
Ibrahim, E. E., Babaei-Jadidi, R., Saadeddin, A., Spencer-Dene, B., Hossaini, S., Abuzinadah, M., Li, N., Fadhil, W., Ilyas, M., Bonnet, D., & Nateri, A. S. (2012). Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms. STEM CELLS, 30(10), 2076-2087. https://doi.org/10.1002/stem.1182

Embryonic NANOG (NANOG1) is considered as an important regulator of pluripotency while NANOGP8 (NANOG-pseudogene) plays a role in tumorigenesis. Herein, we show NANOG is expressed from both NANOG1 and NANOGP8 in human colorectal cancers (CRC). Enforc... Read More about Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms.

Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis (2010)
Journal Article
Da Costa, C. R., Villadiego, J., Sancho, R., Fontana, X., Packham, G., Nateri, A. S., & Behrens, A. (2010). Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis. Molecular and Cellular Biology, 30(15), 3842-3852. https://doi.org/10.1128/MCB.01610-09

In the nervous system, cell death by apoptosis plays a critical role during normal development and pathological neurodegeneration. Jun N-terminal kinases (JNKs) are essential regulators of neuronal apoptosis. The AP-1 transcription factor c-Jun is ph... Read More about Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis.

JNK signalling modulates intestinal homeostasis and tumourigenesis in mice (2009)
Journal Article
Sancho, R., Nateri, A. S., De Vinuesa, A. G., Aguilera, C., Nye, E., Spencer-Dene, B., & Behrens, A. (2009). JNK signalling modulates intestinal homeostasis and tumourigenesis in mice. EMBO Journal, 28(13), 1843-1854. https://doi.org/10.1038/emboj.2009.153

Wnt signalling is a crucial signalling pathway controlling intestinal homeostasis and cancer. We show here that the JNK MAP kinase pathway and one of its most important substrates, the AP-1 transcription factor c-Jun, modulates Wnt signalling strengt... Read More about JNK signalling modulates intestinal homeostasis and tumourigenesis in mice.

C-terminal Tensin-like (CTEN) is an oncogene which alters cell motility possibly through repression of E-cadherin in colorectal cancer (2008)
Journal Article
Albasri, A., Seth, R., Jackson, D., Benhasouna, A., Crook, S., Nateri, A. S., Chapman, R., & Ilyas, M. (2009). C-terminal Tensin-like (CTEN) is an oncogene which alters cell motility possibly through repression of E-cadherin in colorectal cancer. The Journal of Pathology, 218(1), 57-65. https://doi.org/10.1002/path.2508

The Tensin gene family encodes proteins thought to modulate integrin function. C-terminal Tensin-like (CTEN) is a member of the Tensin gene family which lacks the N-terminus actin-binding domain. Cten is reported to have both oncogenic and tumour-sup... Read More about C-terminal Tensin-like (CTEN) is an oncogene which alters cell motility possibly through repression of E-cadherin in colorectal cancer.

The streptavidin/biotinylated DNA/protein bound complex protocol for determining the association of c-JUN protein with NANOG promoter (2007)
Journal Article
SHAMS-NATERI, A., & BABAEI-JADIDI, R. (2013). The streptavidin/biotinylated DNA/protein bound complex protocol for determining the association of c-JUN protein with NANOG promoter. Current Protocols in Stem Cell Biology, 25(UNIT 1B.10), 1-13

Chromatin immunoprecipitation (ChIP) is a widely used and pre-eminent technique for detecting the association of an individual protein or a particular protein complex with its specific DNA sequence(s) in vivo. Herein we introduce a novel and simple b... Read More about The streptavidin/biotinylated DNA/protein bound complex protocol for determining the association of c-JUN protein with NANOG promoter.

Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development (2005)
Journal Article
Nateri, A. S., Spencer-Dene, B., & Behrens, A. (2005). Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature, 437(7056), 281-285. https://doi.org/10.1038/nature03914

The proto-oncoprotein c-Jun is a component of the AP-1 transcription factor, the activity of which is augmented in many tumour types. An important mechanism in the stimulation of AP-1 function is amino-terminal phosphorylation of c-Jun by the c-Jun N... Read More about Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development.

The AP-1 transcription factor c-Jun is required for efficient axonal regeneration (2004)
Journal Article
Raivich, G., Bohatschek, M., Da Costa, C., Iwata, O., Galiano, M., Hristova, M., Nateri, A. S., Makwana, M., Riera-Sans, L., Wolfer, D. P., Lipp, H. P., Aguzzi, A., Wagner, E. F., & Behrens, A. (2004). The AP-1 transcription factor c-Jun is required for efficient axonal regeneration. Neuron, 43(1), 57-67. https://doi.org/10.1016/j.neuron.2004.06.005

Nerve injury triggers numerous changes in the injured neurons and surrounding nonneuronal cells that ultimately result in successful target reinnervation or cell death. c-Jun is a component of the heterodimeric AP-1 transcription factor, and c-Jun is... Read More about The AP-1 transcription factor c-Jun is required for efficient axonal regeneration.

The Ubiquitin Ligase SCF Fbw7 Antagonizes Apoptotic JNK Signaling (2004)
Journal Article
Nateri, A. S., Riera-Sans, L., Da Costa, C., & Behrens, A. (2004). The Ubiquitin Ligase SCF Fbw7 Antagonizes Apoptotic JNK Signaling. Science, 303(5662), 1374-1378. https://doi.org/10.1126/science.1092880

Jun N-terminal kinases (JNKs) are essential for neuronal microtubute assembly and apoptosis. Phosphorylation of the activating protein 1 (AP1) transcription factor c-Jun, at multiple sites within its transactivation domain, is required for JNK-induce... Read More about The Ubiquitin Ligase SCF Fbw7 Antagonizes Apoptotic JNK Signaling.