Dr Madeleine King's Outputs (2)

A Modified Cell-Penetrating Peptide Enhances Insulin and Oxytocin Delivery across an RPMI 2650 Nasal Epithelial Cell Barrier In Vitro (2024)
Journal Article
Wong, S., Brown, A. D., Abrahams, A. B., Nurzak, A. N., Eltaher, H. M., Sykes, D. A., Veprintsev, D. B., Fone, K. C. F., Dixon, J. E., & King, M. V. (2024). A Modified Cell-Penetrating Peptide Enhances Insulin and Oxytocin Delivery across an RPMI 2650 Nasal Epithelial Cell Barrier In Vitro. Pharmaceutics, 16(10), Article 1267. https://doi.org/10.3390/pharmaceutics16101267

Background/Objectives: Peptide-based treatments represent an expanding area and require innovative approaches to enhance bioavailability. Combination with cell-penetrating peptides (CPPs) is an attractive strategy to improve non-invasive delivery acr... Read More about A Modified Cell-Penetrating Peptide Enhances Insulin and Oxytocin Delivery across an RPMI 2650 Nasal Epithelial Cell Barrier In Vitro.

GABAergic and inflammatory changes in the frontal cortex following neonatal PCP plus isolation rearing, as a dual-hit neurodevelopmental model for schizophrenia (2024)
Journal Article
Cale, J. A., Chauhan, E. J., Cleaver, J. J., Fusciardi, A. R., McCann, S., Waters, H. C., Žavbi, J., & King, M. V. (2024). GABAergic and inflammatory changes in the frontal cortex following neonatal PCP plus isolation rearing, as a dual-hit neurodevelopmental model for schizophrenia. Molecular Neurobiology, 61, 6968-6983. https://doi.org/10.1007/s12035-024-03987-y

The pathogenesis of schizophrenia begins in early neurodevelopment and leads to excitatory-inhibitory imbalance. It is therefore essential that preclinical models used to understand disease, select drug targets and evaluate novel therapeutics encompa... Read More about GABAergic and inflammatory changes in the frontal cortex following neonatal PCP plus isolation rearing, as a dual-hit neurodevelopmental model for schizophrenia.