Dr PAUL LEIGHTON's Outputs (99)

Cognitive assessment in multiple sclerosis clinical care: A qualitative evaluation of stakeholder perceptions and preferences (2021)
Journal Article
Elwick, H., Smith, L., Mhizha-Murira, J. R., Topcu, G., Leighton, P., Drummond, A., Evangelou, N., & Das Nair, R. (2022). Cognitive assessment in multiple sclerosis clinical care: A qualitative evaluation of stakeholder perceptions and preferences. Neuropsychological Rehabilitation, 32(7), 1456-1474. https://doi.org/10.1080/09602011.2021.1899942

There is a growing consensus that cognitive assessments should form part of routine clinical care in Multiple Sclerosis (MS). However, what remains unclear is which assessments are preferred by “stakeholders” (including people with MS, family members... Read More about Cognitive assessment in multiple sclerosis clinical care: A qualitative evaluation of stakeholder perceptions and preferences.

Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers (2021)
Journal Article
Muller, I., Stuart, B., Sach, T., Hooper, J., Wilczynska, S., Steele, M., Greenwell, K., Sivyer, K., Yardley, L., Williams, H. C., Chalmers, J. R., Leighton, P., Howells, L. M., Ridd, M. J., Lawton, S., Griffiths, G., Nuttall, J., Langan, S. M., Roberts, A., Ahmed, A., …Santer, M. (2021). Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers. BMJ Open, 11(2), Article e045583. https://doi.org/10.1136/bmjopen-2020-045583

Introduction Eczema care requires management of triggers and various treatments. We developed two online behavioural interventions to support eczema care called ECO (Eczema Care Online) for young people and ECO for families. This protocol describes t... Read More about Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers.

Developing a core outcome set for hand fractures and joint injuries in adults: a systematic review (2021)
Journal Article
Deshmukh, S. R., Mousoulis, C., Marson, B. A., Grindlay, D., Karantana, A., the Core Outcome Set for Hand Fractures and Joint Injuries in Adults Group, Leighton, P., & Montgomery, A. A. (2021). Developing a core outcome set for hand fractures and joint injuries in adults: a systematic review. Journal of Hand Surgery (European Volume), 46(5), 488-495. https://doi.org/10.1177/1753193420983719

© The Author(s) 2021. This study identifies the treatment outcome domains used in recently published studies on the treatment of hand fractures and joint injuries with the aim to inform development of a core outcome set. Seven databases were searched... Read More about Developing a core outcome set for hand fractures and joint injuries in adults: a systematic review.

Home-based narrowband UVB, topical corticosteroid or combination for children and adults with vitiligo: HI-light vitiligo three-arm RCT (2020)
Journal Article
Batchelor, J. M., Thomas, K. S., Akram, P., Azad, J., Bewley, A., Chalmers, J. R., Cheung, S. T., Duley, L., Eleftheriadou, V., Ellis, R., Ferguson, A., Goulding, J. M., Haines, R. H., Hamad, H., Ingram, J. R., Laguda, B., Leighton, P., Levell, N., Makrygeorgou, A., Meakin, G. D., …Montgomery, A. A. (2020). Home-based narrowband UVB, topical corticosteroid or combination for children and adults with vitiligo: HI-light vitiligo three-arm RCT. Health Technology Assessment, 24(64), 1-164. https://doi.org/10.3310/hta24640

Background: Systematic reviews suggest that narrowband ultraviolet B light combined with treatments such as topical corticosteroids may be more effective than monotherapy for vitiligo. Objective: To explore the clinical effectiveness and cost-effecti... Read More about Home-based narrowband UVB, topical corticosteroid or combination for children and adults with vitiligo: HI-light vitiligo three-arm RCT.

Defining stable glaucoma: a Delphi consensus survey of UK optometrists with a specialist interest in Glaucoma (2020)
Journal Article
Lakhani, B. K., Giannouladis, K., Leighton, P., Spry, P. G. D., Harper, R. A., & King, A. J. (2021). Defining stable glaucoma: a Delphi consensus survey of UK optometrists with a specialist interest in Glaucoma. Eye, 35(9), 2524-2534. https://doi.org/10.1038/s41433-020-01251-w

Background
Increasing demand on hospital services has led to the development of alternative community-based services, often run by optometrists for monitoring ‘stable’ and low-risk glaucoma patients.

Methods
An online Delphi exercise was underta... Read More about Defining stable glaucoma: a Delphi consensus survey of UK optometrists with a specialist interest in Glaucoma.

Surgical fixation compared with cast immobilisation for adults with a bicortical fracture of the scaphoid waist: the SWIFFT RCT (2020)
Journal Article
Dias, J., Brealey, S., Cook, L., Fairhurst, C., Hinde, S., Leighton, P., Choudhary, S., Costa, M., Hewitt, C., Hodgson, S., Jefferson, L., Jeyapalan, K., Keding, A., Northgraves, M., Palmer, J., Rangan, A., Richardson, G., Taub, N., Tew, G., Thompson, J., & Torgerson, D. (2020). Surgical fixation compared with cast immobilisation for adults with a bicortical fracture of the scaphoid waist: the SWIFFT RCT. Health Technology Assessment, 24(52), a-234. https://doi.org/10.3310/hta24520

Background: Scaphoid fractures account for 90% of carpal fractures and occur predominantly in young men. Immediate surgical fixation of this fracture has increased. Objective: To compare the clinical effectiveness and cost-effectiveness of surgical f... Read More about Surgical fixation compared with cast immobilisation for adults with a bicortical fracture of the scaphoid waist: the SWIFFT RCT.

An interview study to determine the experiences of cellulitis diagnosis amongst health care professionals in the UK (2020)
Journal Article
Patel, M., Lee, S., Levell, N., Smart, P., Kai, J., Thomas, K., & Leighton, P. (2020). An interview study to determine the experiences of cellulitis diagnosis amongst health care professionals in the UK. BMJ Open, 10, Article e034692. https://doi.org/10.1136/bmjopen-2019-034692

Objectives: To explore health care professionals (HCPs) experiences and challenges in diagnosing suspected lower limb cellulitis.

Setting: UK nationwide.

Participants: 20 qualified HCPs, who had a minimum of two years clinical experience as a... Read More about An interview study to determine the experiences of cellulitis diagnosis amongst health care professionals in the UK.

An interview study of the experiences of cellulitis diagnosis amongst health care professionals (2020)
Journal Article
Patel, M., Ing Lee, S., Levell, N. J., Smart, P., Kai, J., Thomas, K. S., & Leighton, P. (2020). An interview study of the experiences of cellulitis diagnosis amongst health care professionals. BMJ Open, 10(10), Article e034692. https://doi.org/10.1136/+bmjopen-2019-034692

Objectives: To explore healthcare professionals (HCPs) experiences and challenges in diagnosing suspected lower limb cellulitis.

Setting: UK nationwide.

Participants: 20 qualified HCPs, who had a minimum of 2 years clinical experience as an HCP... Read More about An interview study of the experiences of cellulitis diagnosis amongst health care professionals.

Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners (2020)
Journal Article
Smith, L., Elwick, H., Mhizha-Murira, J., Topcu, G., Bale, C., Evangelou, N., Timmons, S., Leighton, P., & Das Nair, R. (2021). Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners. Multiple Sclerosis and Related Disorders, 49, Article 102563. https://doi.org/10.1016/j.msard.2020.102563

Background: Cognitive problems are a common and debilitating symptom of multiple sclerosis (MS). Screening and treatment for cognitive problems are recommended, however these are not routinely delivered in UK clinics.

We collected and synthesised... Read More about Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners.

Surgery versus cast immobilisation for adults with a bicortical fracture of the scaphoid waist (SWIFFT): a pragmatic, multicentre, open-label, randomised superiority trial (2020)
Journal Article
Dias, J. J., Brealey, S. D., Fairhurst, C., Amirfeyz, R., Bhowal, B., Blewitt, N., Brewser, M., Brown, D., Choudhary, S., Coapes, C., Cook, L., Costa, M., Davis, T., DisMascio, L., Giddins, G., Hedley, H., Hewitt, C., Hinde, S., Hobby, J., Hodgson, S., …Warwick, D. (2020). Surgery versus cast immobilisation for adults with a bicortical fracture of the scaphoid waist (SWIFFT): a pragmatic, multicentre, open-label, randomised superiority trial. Lancet, 396(10248), 390-401. https://doi.org/10.1016/S0140-6736%2820%2930931-4

Background
Scaphoid fractures account for 90% of carpal fractures and occur predominantly in young men. Immediate surgical fixation of this fracture has increased, in spite of insufficient evidence of improved outcomes over non-surgical management.... Read More about Surgery versus cast immobilisation for adults with a bicortical fracture of the scaphoid waist (SWIFFT): a pragmatic, multicentre, open-label, randomised superiority trial.

Outcome domains in lichen sclerosus (2020)
Journal Article
Goodrum, C., Leighton, P., & Simpson, R. (2020). Outcome domains in lichen sclerosus. British Journal of Dermatology, 183(5), 966-968. https://doi.org/10.1111/bjd.19253

Lichen Sclerosus (LS) is a chronic inflammatory dermatosis predominantly affecting the genitals. It can affect men, women and children. LS affecting female genitalia typically presents with itchy patches that impact on physical and psychosocial‐sexua... Read More about Outcome domains in lichen sclerosus.

Protocol for a multi-centre randomised controlled stand-alone feasibility trial to assess potential effectiveness and cost-effectiveness of digital hearing aids in patients with tinnitus and hearing loss (the HUSH trial) (2020)
Journal Article
Haines, R., White, J., Meakin, G., Tan, W., Hepburn, T., Leighton, P., Hall, D., & Sereda, M. (2020). Protocol for a multi-centre randomised controlled stand-alone feasibility trial to assess potential effectiveness and cost-effectiveness of digital hearing aids in patients with tinnitus and hearing loss (the HUSH trial). Pilot and Feasibility Studies, 6, Article 41. https://doi.org/10.1186/s40814-020-00582-5

Background: The most common management strategy for tinnitus provided in UK audiology clinics is education and advice. This may also be combined with some form of sound therapy (e.g. digital hearing aids). While education and advice is generally prov... Read More about Protocol for a multi-centre randomised controlled stand-alone feasibility trial to assess potential effectiveness and cost-effectiveness of digital hearing aids in patients with tinnitus and hearing loss (the HUSH trial).

Confidence of recurrent cellulitis self-diagnosis among people with lymphoedema: a qualitative interview study (2019)
Journal Article
Patel, M., Lee, S. I., Levell, N. J., Smart, P., Kai, J., Thomas, K. S., & Leighton, P. (2020). Confidence of recurrent cellulitis self-diagnosis among people with lymphoedema: a qualitative interview study. British Journal of General Practice, 70(691), e130-e137. https://doi.org/10.3399/bjgp19X707909

© British Journal of General Practice 2020. BACKGROUND: Cellulitis can sometimes be challenging for healthcare professionals to diagnose, with no validated diagnostic criteria available. Supporting healthcare professionals to make a more accurate dia... Read More about Confidence of recurrent cellulitis self-diagnosis among people with lymphoedema: a qualitative interview study.

Characterising burden of treatment in cystic fibrosis to identify priority areas for clinical trials (2019)
Journal Article
Davies, G., Rowbotham, N. J., Smith, S., Elliot, Z. C., Gathercole, K., Rayner, O., Leighton, P. A., Herbert, S., Duff, A. J., Chandran, S., Daniels, T., Nash, E. F., & Smyth, A. R. (2020). Characterising burden of treatment in cystic fibrosis to identify priority areas for clinical trials. Journal of Cystic Fibrosis, 19(3), 499-502. https://doi.org/10.1016/j.jcf.2019.10.025

In a recent James Lind Alliance Priority Setting Partnership in cystic fibrosis (CF) the top priority clinical research question was: “What are effective ways of simplifying the treatment burden of people with CF?” We aimed to summarise the lived exp... Read More about Characterising burden of treatment in cystic fibrosis to identify priority areas for clinical trials.

What matters to patients? A thematic analysis of patient information and support needs (2019)
Journal Article
Osborn, K., Bradley, J., Knox, E., & Leighton, P. (2020). What matters to patients? A thematic analysis of patient information and support needs. Eye, 34, 103–115. https://doi.org/10.1038/s41433-019-0644-3

A thematic analysis was done to look at qualitative free text responses to a members survey carried out by the International Glaucoma Association (IGA) in 2017. A further analysis was done on data from calls made to the IGA’s glaucoma helpline during... Read More about What matters to patients? A thematic analysis of patient information and support needs.

SKIP (Supporting Kids with diabetes In Physical activity): Feasibility of a randomised controlled trial of a digital intervention for 9-12 year olds with type 1 diabetes mellitus (2019)
Presentation / Conference Contribution
Blake, H., Knox, E., Randell, T., Leighton, P., Guo, B., Greening, J., Bethan Davies, E., Amor, L., & Glazebrook, C. (2019, October). SKIP (Supporting Kids with diabetes In Physical activity): Feasibility of a randomised controlled trial of a digital intervention for 9-12 year olds with type 1 diabetes mellitus. Presented at 5th International Clinical Trials Methodology Conference (ICTMC 2019), Brighton, UK

Introduction: Physical activity is important for children with type 1 diabetes mellitus (T1DM) but it is unclear whether interventions delivered online are feasible, acceptable to patients and efficacious. The aim was to assess the feasibility and ac... Read More about SKIP (Supporting Kids with diabetes In Physical activity): Feasibility of a randomised controlled trial of a digital intervention for 9-12 year olds with type 1 diabetes mellitus.

Adapting the James Lind Alliance priority setting process to better support patient participation: an example from cystic fibrosis (2019)
Journal Article
Rowbotham, N. J., Smith, S. J., Elliott, Z. C., Leighton, P. A., Rayner, O. C., Morley, R., & Smyth, A. R. (2019). Adapting the James Lind Alliance priority setting process to better support patient participation: an example from cystic fibrosis. Research Involvement and Engagement, 5(1), Article 24. https://doi.org/10.1186/s40900-019-0159-x

Background
The James Lind Alliance (JLA) method is well recognised for setting research priorities. The JLA approach involves a combination of surveys and workshop interactions between patients, carers and health care professionals to identify and... Read More about Adapting the James Lind Alliance priority setting process to better support patient participation: an example from cystic fibrosis.

Treatment interventions for hand fractures and joint injuries: a scoping review of randomized controlled trials (2019)
Journal Article
Mousoulis, C., Thomas, K., Leighton, P., Deshmukh, S., Grindlay, D., & Karantana, A. (2020). Treatment interventions for hand fractures and joint injuries: a scoping review of randomized controlled trials. Journal of Hand Surgery (European Volume), 45(2), 111-118. https://doi.org/10.1177/1753193419865897

The aim of this study was to identify and assess all existing randomized studies on treatment interventions for hand fractures and joint injuries, to inform practice and plan future research. PubMed, Cochrane CENTRAL, MEDLINE and Embase were searche... Read More about Treatment interventions for hand fractures and joint injuries: a scoping review of randomized controlled trials.

Seeking a practical definition of stable glaucoma: a Delphi consensus survey of UK glaucoma consultants (2019)
Journal Article
Lakhani, B. K., Giannouladis, K., Leighton, P., & King, A. J. (2020). Seeking a practical definition of stable glaucoma: a Delphi consensus survey of UK glaucoma consultants. Eye, 34(2), 335-343. https://doi.org/10.1038/s41433-019-0540-x

© 2019, The Author(s), under exclusive licence to The Royal College of Ophthalmologists. Background: To generate a practical and clinically useful consensus definition of ‘stable glaucoma’ to aid provision of glaucoma services in the UK and to provid... Read More about Seeking a practical definition of stable glaucoma: a Delphi consensus survey of UK glaucoma consultants.

ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation) randomised controlled, feasibility in older people trial: a study protocol (2019)
Journal Article
van Berkel, D., Ong, T., Drummond, A., Hendrick, P., Leighton, P., Jones, M., Salem, K., Quraishi, N., Brookes, C., Suazo Di Paola, A., Edwards, S., & Sahota, O. (2019). ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation) randomised controlled, feasibility in older people trial: a study protocol. BMJ Open, 9(7), Article 032111. https://doi.org/10.1136/bmjopen-2019-032111