Dr Alexander Tarr's Outputs (4)

Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host (2012)
Journal Article
Brown, R. J., Hudson, N., Wilson, G., Rehman, S. U., Jabbari, S., Hu, K., Tarr, A. W., Borrow, P., Joyce, M., Lewis, J., Zhu, L. F., Law, M., Kneteman, N., Tyrrell, D. L., McKeating, J. A., & Ball, J. K. (2012). Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host. Journal of Virology, 86(22), https://doi.org/10.1128/JVI.01079-12

Genetic variability is a hallmark of RNA virus populations. However, transmission to a new host often results in a marked decrease in population diversity. This genetic bottlenecking is observed during hepatitis C virus (HCV) transmission and can ari... Read More about Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host.

Naturally occurring antibodies that recognize linear epitopes in the amino terminus of the hepatitus C virus E2 protein confer noninterfering, additive neutralization (2012)
Journal Article
Tarr, A. W., Urbanowicz, R. A., Jayaraj, D., Brown, R. J., McKeating, J. A., Irving, W. L., & Ball, J. K. (2012). Naturally occurring antibodies that recognize linear epitopes in the amino terminus of the hepatitus C virus E2 protein confer noninterfering, additive neutralization. Journal of Virology, 86(5), https://doi.org/10.1128/JVI.06492-11

Chronic hepatitis C virus (HCV) infection can persist even in the presence of a broadly neutralizing antibody response. Various mechanisms that underpin viral persistence have been proposed, and one of the most recently proposed mechanisms is the pre... Read More about Naturally occurring antibodies that recognize linear epitopes in the amino terminus of the hepatitus C virus E2 protein confer noninterfering, additive neutralization.

The Role of Humoral Innate Immunity in Hepatitis C Virus Infection (2012)
Journal Article
Tarr, A. W., Urbanowicz, R. A., & Ball, J. K. (2012). The Role of Humoral Innate Immunity in Hepatitis C Virus Infection. Viruses, 4(1), 1-27. https://doi.org/10.3390/v4010001

Infection with Hepatitis C Virus (HCV) causes chronic disease in approximately 80% of cases, resulting in chronic inflammation and cirrhosis. Current treatments are not completely effective, and a vaccine has yet to be developed. Spontaneous resoluti... Read More about The Role of Humoral Innate Immunity in Hepatitis C Virus Infection.

The role of neutralizing antibodies in hepatitis C virus infection (2012)
Journal Article
Edwards, V. C., Tarr, A. W., Urbanowicz, R. A., & Ball, J. K. (2012). The role of neutralizing antibodies in hepatitis C virus infection. Journal of General Virology, 93(1), 1-19. https://doi.org/10.1099/vir.0.035956-0

Hepatitis C virus (HCV) is a blood-borne virus estimated to infect around 170 million people worldwide and is, therefore, a major disease burden. In some individuals the virus is spontaneously cleared during the acute phase of infection, whilst in ot... Read More about The role of neutralizing antibodies in hepatitis C virus infection.