Dr Alexander Tarr's Outputs (7)

Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge (2007)
Journal Article
Law, M., Maruyama, T., Lewis, J., Giang, E., Tarr, A. W., Stamataki, Z., Gastaminza, P., Chisari, F. V., Jones, I. M., Fox, R. I., Ball, J. K., McKeating, J. A., Kneteman, N. M., & Burton, D. R. (2008). Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. Nature Medicine, 14(1), 25-27. https://doi.org/10.1038/nm1698

A major problem in hepatitis C virus (HCV) immunotherapy or vaccine design is the extreme variability of the virus. We identified human monoclonal antibodies (mAbs) that neutralize genetically diverse HCV isolates and protect against heterologous HCV... Read More about Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge.

Determination of the human antibody response to the epitope defined by the hepatitis C virus-neutralizing monoclonal antibody AP33 (2007)
Journal Article
Tarr, A. W., Owsianka, A. M., Jayaraj, D., Brown, R. J., Hickling, T. P., Irving, W. L., Patel, A. H., & Ball, J. K. (2007). Determination of the human antibody response to the epitope defined by the hepatitis C virus-neutralizing monoclonal antibody AP33. Journal of General Virology, 88(11), 2991-3001. https://doi.org/10.1099/vir.0.83065-0

Hepatitis C virus (HCV) is a major cause of liver disease worldwide and there is a pressing need for the development of a preventative vaccine as well as new treatments. It was recently demonstrated that the mouse monoclonal antibody (mAb) AP33 poten... Read More about Determination of the human antibody response to the epitope defined by the hepatitis C virus-neutralizing monoclonal antibody AP33.

Human combinatorial libraries yield rare antibodies that broadly neutralize hepatitis C virus (2007)
Journal Article
Johansson, D. X., Voisset, C., Tarr, A. W., Aung, M., Ball, J. K., Dubuisson, J., & Persson, M. A. (2007). Human combinatorial libraries yield rare antibodies that broadly neutralize hepatitis C virus. Proceedings of the National Academy of Sciences, 104(41), 16269-16274. https://doi.org/10.1073/pnas.0705522104

One way to dissect the antibody response to an invading microorganism is to clone the antibody repertoire from immune donors and subsequently characterize the specific antibodies. Recently, methodological advances have allowed investigations of neutr... Read More about Human combinatorial libraries yield rare antibodies that broadly neutralize hepatitis C virus.

Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins (2007)
Book Chapter
Tarr, A. W., Owsianka, A. M., Szwejk, A., Ball, J. K., & Patel, A. H. (2007). Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins. In R. J. Sugrue (Ed.), Glycovirology Protocols (177-197). Humana Press. https://doi.org/10.1007/978-1-59745-393-6_13

Hepatitis C virus (HCV) infection is a major cause of severe chronic liver disease including cirrhosis and hepatocellular carcinoma. HCV has been classified into six major genotypes that exhibit extensive genetic variability, particularly in the enve... Read More about Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins.

Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins (2007)
Book Chapter
Tarr, A. W., Owsianka, A. M., Szwejk, A., Ball, J. K., & Patel, A. H. (2007). Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins. In R. J. Sugrue (Ed.), Glycovirology Protocols (177-197). Humana Press. https://doi.org/10.1007/978-1-59745-393-6_13

Hepatitis C virus (HCV) infection is a major cause of severe chronic liver disease including cirrhosis and hepatocellular carcinoma. HCV has been classified into six major genotypes that exhibit extensive genetic variability, particularly in the enve... Read More about Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins.

Cloning, Expression, and Functional Analysis of Patient-Derived Hepatitis C Virus Glycoproteins (2007)
Book Chapter
Tarr, A. W., Owsianka, A. M., Szwejk, A., Ball, J. K., & Patel, A. H. (2007). Cloning, Expression, and Functional Analysis of Patient-Derived Hepatitis C Virus Glycoproteins. In Glycovirology Protocols (177-197). Humana Press. https://doi.org/10.1385/1-59745-393-5%3A177

Hepatitis C virus (HCV) infection is a major cause of severe chronic liver disease including cirrhosis and hepatocellular carcinoma. HCV has been classified into six major genotypes that exhibit extensive genetic variability, particularly in the enve... Read More about Cloning, Expression, and Functional Analysis of Patient-Derived Hepatitis C Virus Glycoproteins.

Cross-genotype characterization of genetic diversity and molecular adaptation in hepatitis C virus envelope glycoprotein genes (2007)
Journal Article
Brown, R. J., Tarr, A. W., McClure, C. P., Juttla, V. S., Tagiuri, N., Irving, W. L., & Ball, J. K. (2007). Cross-genotype characterization of genetic diversity and molecular adaptation in hepatitis C virus envelope glycoprotein genes. Journal of General Virology, 88(2), 458-469. https://doi.org/10.1099/vir.0.82357-0

Investigation of the mechanisms underlying hepatitis C virus (HCV) envelope glycoprotein gene evolution will greatly assist rational development of broadly neutralizing antibody-based vaccines or vaccine components. Previously, comprehensive cross-ge... Read More about Cross-genotype characterization of genetic diversity and molecular adaptation in hepatitis C virus envelope glycoprotein genes.