Dr HUW WILLIAMS's Outputs (39)

Targeted PEG-poly(glutamic acid) complexes for inhalation protein delivery to the lung (2019)
Journal Article
Nieto-Orellana, A., Li, H., Rosiere, R., Wauthoz, N., Williams, H., Monteiro, C., Bosquillon, C., Childerhouse, N., Keegan, G., Coghlan, D., Mantovani, G., & Stolnik, S. (2019). Targeted PEG-poly(glutamic acid) complexes for inhalation protein delivery to the lung. Journal of Controlled Release, 316, 250-262. https://doi.org/10.1016/j.jconrel.2019.10.012

Pulmonary delivery is increasingly seen as an attractive, non-invasive route for the delivery of forthcoming protein therapeutics. In this context, here we describe protein complexes with a new ‘complexing excipient’ - vitamin B12-targeted poly(ethyl... Read More about Targeted PEG-poly(glutamic acid) complexes for inhalation protein delivery to the lung.

Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells (2019)
Journal Article
Liu, Z., Turyanska, L., Zamberlan, F., Pacifico, S., Bradshaw, T. D., Moro, F., Fay, M. W., Williams, H., & Thomas, N. R. (2019). Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells. Nanotechnology, 30(50), Article 505102. https://doi.org/10.1088/1361-6528/ab437c

We report on the synthesis of water-soluble gold nanoclusters capped with polyethylene glycol (PEG)-based ligands and further functionalized with folic acid for specific cellular uptake. The dihydrolipoic acid-PEG-based ligands terminated with -OMe,... Read More about Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells.

Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib (2019)
Journal Article
Morgan, J., Saleem, M., Ng, R., Armstrong, C., Wong, S. S., Caulton, S. G., Fickling, A., Williams, H. E., Munday, A. D., Lopez, J. A., Searle, M. S., & Emsley, J. (2019). Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib. Blood Advances, 3(9), 1450-1459. https://doi.org/10.1182/bloodadvances.2018027011

Cell-surface receptor interactions between leukocyte integrin macrophage-1 antigen (Mac-1, also known as CR3, aMb2, CD11b/CD18) and platelet glycoprotein Iba (GPIba) are critical to vascular inflammation. To define the key residues at the binding inter... Read More about Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib.

A Highly Active Bidentate Magnesium Catalyst for Amine‐Borane Dehydrocoupling: Kinetic and Mechanistic Studies (2019)
Journal Article
Ried, A., Taylor, L., Geer, A., Williams, H., Lewis, W., Blake, A., & Kays, D. L. (2019). A Highly Active Bidentate Magnesium Catalyst for Amine‐Borane Dehydrocoupling: Kinetic and Mechanistic Studies. Chemistry - A European Journal, 25(27), 6840-6846. https://doi.org/10.1002/chem.201901197

A magnesium complex (1) featuring a bidentate aminopyridinato ligand is a remarkably selective catalyst for the dehydrocoupling of amine-boranes. This reaction proceeds to completion with low catalyst loadings (1 mol%) und... Read More about A Highly Active Bidentate Magnesium Catalyst for Amine‐Borane Dehydrocoupling: Kinetic and Mechanistic Studies.

Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement (2019)
Journal Article
Faas, H. M., Krupa, J. L., Taylor, A. J., Zamberlan, F., Philp, C. J., Williams, H. E., Johnson, S. R., Pavlovskaya, G. E., Thomas, N. R., & Meersmann, T. (2019). Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement. Contrast Media and Molecular Imaging, 2019, 1-13. https://doi.org/10.1155/2019/4826520

Paramagnetic gadolinium ions (Gd III), complexed within DOTA-based chelates, have become useful tools to increase the magnetic resonance imaging (MRI) contrast in tissues of interest. Recently, " on/off " probes serving as 19 F·MRI biosensor for targ... Read More about Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement.

DNA replication initiation in Bacillus subtilis: Structural and functional characterization of the essential DnaA-DnaD interaction (2018)
Journal Article
Martin, E., Williams, H. E., Pitoulias, M., Stevens, D., Winterhalter, C., Craggs, T. D., Murray, H., Searle, M. S., & Soultanas, P. (2019). DNA replication initiation in Bacillus subtilis: Structural and functional characterization of the essential DnaA-DnaD interaction. Nucleic Acids Research, 47(4), 2101-2112. https://doi.org/10.1093/nar/gky1220

© 2018 The Author(s). The homotetrameric DnaD protein is essential in low G+C content gram positive bacteria and is involved in replication initiation at oriC and re-start of collapsed replication forks. It interacts with the ubiquitously conserved b... Read More about DNA replication initiation in Bacillus subtilis: Structural and functional characterization of the essential DnaA-DnaD interaction.

Sustenance and performance: nutritional reserves, longevity and contest outcomes of fed and starved adult parasitoid wasps (2018)
Journal Article
Snart, C. J., Kapranas, A., Williams, H., Barrett, D. A., & Hardy, I. C. (2018). Sustenance and performance: nutritional reserves, longevity and contest outcomes of fed and starved adult parasitoid wasps. Frontiers in Ecology and Evolution, https://doi.org/10.3389/fevo.2018.00012

Dyadic contests for possession of resources occur across a wide range of animal taxa, with contest outcome often being heavily influenced by the energetic reserves of the competitors. The majority of studied parasitoid wasps lack de novo lipogenesis,... Read More about Sustenance and performance: nutritional reserves, longevity and contest outcomes of fed and starved adult parasitoid wasps.

Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging (2018)
Journal Article
Zamberlan, F., Turyanska, L., Patanè, A., Liu, Z., Williams, H., Fay, M., Clarke, P., Imamura, Y., Jin, T., Bradshaw, T., Thomas, N., & Grabowska, A. (in press). Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging. Journal of Materials Chemistry B, 6, https://doi.org/10.1039/c7tb02912h

The short shelf-life of water-soluble quantum dots (QDs) due to colloidal instability represents a major drawback to their exploitation. This work examines the colloidal stability of PbS nanoparticles capped with dihydrolipoic acid–polyethylene glyco... Read More about Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging.

Determination of pore network accessibility in hierarchical porous solids (2017)
Journal Article
Rigby, S. P., Hasan, M., Stevens, L., Williams, H. E., & Fletcher, R. S. (2017). Determination of pore network accessibility in hierarchical porous solids. Industrial & Engineering Chemistry Research, 56(50), 14822-14831. https://doi.org/10.1021/acs.iecr.7b04659

This paper validates the hypothesis that the supposedly non-specific adsorbates nitrogen and argon wet heavy metals differently, and shows how this unexpected effect can be actively utilised to deliver information on pore inter-connectivity. To explo... Read More about Determination of pore network accessibility in hierarchical porous solids.

Evidence that Listeria innocua modulates its membrane’s stored curvature elastic stress, but not fluidity, through the cell cycle (2017)
Journal Article
Furse, S., Jakubec, M., Rise, F., Williams, H. E., Rees, C., & Halskau, Ø. (2017). Evidence that Listeria innocua modulates its membrane’s stored curvature elastic stress, but not fluidity, through the cell cycle. Scientific Reports, 7, Article 8012. https://doi.org/10.1038/s41598-017-06855-z

This paper reports that the abundances of endogenous cardiolipin and phosphatidylethanolamine halve during elongation of the Gram-positive bacterium Listeria innocua. The lyotropic phase behaviour of model lipid systems that describe these modulation... Read More about Evidence that Listeria innocua modulates its membrane’s stored curvature elastic stress, but not fluidity, through the cell cycle.

Sources of unsafe primary care for older adults: A mixed-methods analysis of patient safety incident reports (2017)
Journal Article
Cooper, A., Edwards, A., Williams, H., Evans, H. P., Avery, A., Hibbert, P., Makeham, M., Sheikh, A., Donaldson, L. J., & Carson-Stevens, A. (2017). Sources of unsafe primary care for older adults: A mixed-methods analysis of patient safety incident reports. Age and Ageing, 46(5), 833-839. https://doi.org/10.1093/ageing/afx044

© The Author 2017. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. Background: older adults are frequent users of primary healthcare services, but are at increased risk of healthcare-related harm... Read More about Sources of unsafe primary care for older adults: A mixed-methods analysis of patient safety incident reports.

Total Synthesis of the Post‐translationally Modified Polyazole Peptide Antibiotic Goadsporin (2017)
Journal Article
Dexter, H. L., Williams, H. E., Lewis, W., & Moody, C. J. (2017). Total Synthesis of the Post‐translationally Modified Polyazole Peptide Antibiotic Goadsporin. Angewandte Chemie International Edition, 56(11), 3069-3073. https://doi.org/10.1002/anie.201612103

The structurally unique polyazole antibiotic goadsporin contains six heteroaromatic oxazole and thiazole rings integrated into a linear array of amino acids that also contains two dehydroalanine residues. An efficient total synthesis of goadsporin is... Read More about Total Synthesis of the Post‐translationally Modified Polyazole Peptide Antibiotic Goadsporin.

Cyclotrimerisation of isocyanates catalysed by low-coordinate Mn(II) and Fe(II) m-terphenyl complexes (2016)
Journal Article
Sharpe, H. R., Geer, A. M., Williams, H. E., Blundell, T. J., Lewis, W., Blake, A. J., & Kays, D. L. (2017). Cyclotrimerisation of isocyanates catalysed by low-coordinate Mn(II) and Fe(II) m-terphenyl complexes. Chemical Communications, 53(5), 937-940. https://doi.org/10.1039/C6CC07243G

Two- and three-coordinate m-terphenyl complexes of manganese and iron are efficient catalysts for the selective cyclotrimerisation of primary aliphatic isocyanates affording isocyanurates in short reaction times and under mild conditions.

Developing Mn-doped lead sulfide quantum dots for MRI labels (2016)
Journal Article
Turyanska, L., Moro, F., Patanè, A., Barr, J., Köckenberger, W., Taylor, A., Faas, H., Fowler, M. J., Wigmore, P., Trueman, R. C., Williams, H. E. L., & Thomas, N. R. (2016). Developing Mn-doped lead sulfide quantum dots for MRI labels. Journal of Materials Chemistry B, 4(42), 6797-6802. https://doi.org/10.1039/c6tb02574a

Magnetic interactions of Mn2+ions in lead sulfide (PbS) nanocrystals with protons in water are probed by NMR and MRI. A thin layer of capping molecules enables free solvent diffusion to the nanocrystal surface resulting in a decrease of proton relaxa... Read More about Developing Mn-doped lead sulfide quantum dots for MRI labels.

Metabolomics of aging assessed in individual parasitoid wasps (2016)
Journal Article
Kapranas, A., Snart, C. J., Williams, H. E. L., Hardy, I. C., & Barrett, D. A. (2016). Metabolomics of aging assessed in individual parasitoid wasps. Scientific Reports, 6(1), Article 34848. https://doi.org/10.1038/srep34848

Metabolomics studies of low-biomass organisms, such as small insects, have previously relied on the pooling of biological samples to overcome detection limits, particularly using NMR. We show that the differentiation of metabolite profiles of individ... Read More about Metabolomics of aging assessed in individual parasitoid wasps.

Surface sensing of quantum dots by electron spins (2016)
Journal Article
Moro, F., Turyanska, L., Wilman, J., Williams, H. E., Fielding, A. J., & Patanè, A. (in press). Surface sensing of quantum dots by electron spins. Nano Letters, 16(10), https://doi.org/10.1021/acs.nanolett.6b02727

The nanoscale design of quantum dots (QDs) requires advanced analytical techniques. However, those that are commonly used do not have sufficient sensitivity or spatial resolution. Here, we use magnetic resonance techniques combined with paramagnetic... Read More about Surface sensing of quantum dots by electron spins.

SilE is an intrinsically disordered periplasmic ‘molecular sponge' involved in bacterial silver resistance (2016)
Journal Article
Asiani, K. R., Williams, H. E. L., Bird, L., Jenner, M., Searle, M. S., Hobman, J. L., Scott, D. J., & Soultanas, P. (2016). SilE is an intrinsically disordered periplasmic ‘molecular sponge' involved in bacterial silver resistance. Molecular Microbiology, 101(5), 731-742. https://doi.org/10.1111/mmi.13399

Ag+ resistance was initially found on the Salmonella enetrica serovar Typhimurium multi-resistance plasmid pMG101 from burns patients in 1975. The putative model of Ag+ resistance, encoded by the sil operon from pMG101, involves export of Ag+ via an... Read More about SilE is an intrinsically disordered periplasmic ‘molecular sponge' involved in bacterial silver resistance.

Total Synthesis of the Posttranslationally Modified Polyazole Peptide Antibiotic Plantazolicin A (2015)
Journal Article
Wada, H., Williams, H. E. L., & Moody, C. J. (2015). Total Synthesis of the Posttranslationally Modified Polyazole Peptide Antibiotic Plantazolicin A. Angewandte Chemie International Edition, 54(50), 15147-15151. https://doi.org/10.1002/anie.201507062

The power of rhodium carbene methodology in chemistry is demonstrated by the synthesis of a structurally complex polyazole antibiotic. Plantazolicin A, a novel soil bacterium metabolite, comprises a linear array of 10 five-membered rings in two penta... Read More about Total Synthesis of the Posttranslationally Modified Polyazole Peptide Antibiotic Plantazolicin A.

The lipidome and proteome of oil bodies from Helianthus annuus (common sunflower) (2013)
Journal Article
Furse, S., Liddell, S., Ortori, C. A., Williams, H., Neylon, D. C., Scott, D. J., Barrett, D. A., & Gray, D. A. (2013). The lipidome and proteome of oil bodies from Helianthus annuus (common sunflower). Journal of Chemical Biology, 6(2), 63-76. https://doi.org/10.1007/s12154-012-0090-1

In this paper we report the molecular profiling, lipidome and proteome, of the plant organelle known as an oil body (OB). The OB is remarkable in that it is able to perform its biological role (storage of triglycerides) whilst resisting the physical... Read More about The lipidome and proteome of oil bodies from Helianthus annuus (common sunflower).