Dr DANIEL MCWILLIAMS's Outputs (3)

The importance of central sensitization for clinical trials of Disease Modifying Osteoarthritis drugs (DMOADs) (2025)
Journal Article
Walsh, D. A., & McWilliams, D. F. (2025). The importance of central sensitization for clinical trials of Disease Modifying Osteoarthritis drugs (DMOADs). Osteoarthritis Imaging, 5(1), Article 100261. https://doi.org/10.1016/j.ostima.2025.100261

Osteoarthritis (OA) pain is associated with structural changes in the joint, which are usually quantified by imaging techniques. It is anticipated that structural disease modifying OA drugs (DMOADs) would reduce the burden of OA pain. However, nocice... Read More about The importance of central sensitization for clinical trials of Disease Modifying Osteoarthritis drugs (DMOADs).

Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain (2018)
Journal Article
Nwosu, L. N., Gowler, P. R., Burston, J. J., Rizoska, B., Tunblad, K., Lindström, E., Grabowska, U., Li, L., McWilliams, D. F., Walsh, D. A., & Chapman, V. (2018). Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain. PAIN Reports, 3(6), Article 685. https://doi.org/10.1097/PR9.0000000000000685

© 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. Introduction: The mounting evidence that osteoclasts play an important role in osteoarthritis (OA) pain lead us to invest... Read More about Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain.

Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis (2007)
Journal Article
Walsh, D. A., Bonnet, C. S., Turner, E. L., Wilson, D., Situ, M., & McWilliams, D. F. (2007). Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis. Osteoarthritis and Cartilage, 15(7), 743-751. https://doi.org/10.1016/j.joca.2007.01.020

Objectives:
We hypothesised that osteochondral and synovial angiogenesis in osteoarthritis (OA) are independent processes. We investigated whether indices of osteochondral and synovial angiogenesis display different relationships with synovitis, di... Read More about Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis.