Professor KOSTAS TSINTZAS's Outputs (32)

Exercise metabolism in non-obese patients with type 2 diabetes following the acute restoration of normoglycaemia (2017)
Journal Article
Gaffney, C. J., Mansell, P., Stephens, F. B., Macdonald, I. A., & Tsintzas, K. (2017). Exercise metabolism in non-obese patients with type 2 diabetes following the acute restoration of normoglycaemia. Journal of Diabetes Research, 2017, Article 8248725. https://doi.org/10.1155/2017/8248725

This study investigated how acute restoration of normoglycaemia affected energy metabolism during exercise in nonobese patients with type 2 diabetes. Six subjects (mean ± SEM) aged 56.2 ± 2.7 years, with a BMI of 24.5 ± 1.5 kg/m2 and a VO2 peak of 28... Read More about Exercise metabolism in non-obese patients with type 2 diabetes following the acute restoration of normoglycaemia.

Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men (2017)
Journal Article
Tsintzas, K., Stephens, F. B., Snijders, T., Wall, B. T., Cooper, S., Mallinson, J., Verdijk, L. B., & van Loon, L. J. (2017). Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men. Experimental Gerontology, 93, https://doi.org/10.1016/j.exger.2017.03.018

The aim of this study was to examine the temporal relationship between intramyocellular lipid (IMCL) content and the expression of genes associated with IMCL turnover, fat metabolism, and inflammation during recovery from an acute bout of resistance... Read More about Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men.

The causal role of breakfast in energy balance and health: a randomized controlled trial in obese adults (2016)
Journal Article
Chowdhury, E. A., Richardson, J. D., Holman, G. D., Tsintzas, K., Thompson, D., & Betts, J. A. (2016). The causal role of breakfast in energy balance and health: a randomized controlled trial in obese adults. American Journal of Clinical Nutrition, 103(3), https://doi.org/10.3945/ajcn.115.122044

Background: The causal nature of associations between breakfast and health remain unclear in obese individuals.
Objective: We sought to conduct a randomized controlled trial to examine causal links between breakfast habits and components of energy b... Read More about The causal role of breakfast in energy balance and health: a randomized controlled trial in obese adults.

Antibody-mediated inhibition of the FGFR1c isoform induces a catabolic lean state in Siberian hamsters (2015)
Journal Article
Samms, R. J., Lewis, J. E., Lory, A., Fowler, M. J., Cooper, S., Warner, A., Emmerson, P., Adams, A. C., Luckett, J. C., Perkins, A. C., Wilson, D., Barrett, P., Tsintzas, K., & Ebling, F. J. (2015). Antibody-mediated inhibition of the FGFR1c isoform induces a catabolic lean state in Siberian hamsters. Current Biology, 25(22), https://doi.org/10.1016/j.cub.2015.10.010

Hypothalamic tanycytes are considered to function as sensors of peripheral metabolism [1]. To facilitate this role, they express a wide range of receptors, including fibroblast growth factor receptor 1 (FGFR1). Using a monoclonal antibody (IMC-H7) th... Read More about Antibody-mediated inhibition of the FGFR1c isoform induces a catabolic lean state in Siberian hamsters.

Effect of extended morning fasting upon ad libitum lunch intake and associated metabolic and hormonal responses in obese adults (2015)
Journal Article
Chowdhury, E., Richardson, J., Tsintzas, K., Thompson, D., & Betts, J. (in press). Effect of extended morning fasting upon ad libitum lunch intake and associated metabolic and hormonal responses in obese adults. International Journal of Obesity, 40(2), https://doi.org/10.1038/ijo.2015.154

Background/Objectives:

Breakfast omission is positively associated with obesity and increased risk of disease. However, little is known about the acute effects of extended morning fasting upon subsequent energy intake and associated metabolic/reg... Read More about Effect of extended morning fasting upon ad libitum lunch intake and associated metabolic and hormonal responses in obese adults.

Dual effects of fibroblast growth factor 21 on hepatic energy metabolism (2015)
Journal Article
Samms, R. J., Murphy, M., Fowler, M. J., Cooper, S., Emmerson, P., Coskun, T., Adams, A. C., Kharitonenkov, A., Ebling, F. J., & Tsintzas, K. (2015). Dual effects of fibroblast growth factor 21 on hepatic energy metabolism. Journal of Endocrinology, 227(1), https://doi.org/10.1530/JOE-15-0334

The aim of this study was to investigate the mechanisms by which FGF21 affects hepatic integration of carbohydrate and fat metabolism in Siberian hamsters, a natural model of adiposity. Twelve aged matched adult male Siberian hamsters maintained in t... Read More about Dual effects of fibroblast growth factor 21 on hepatic energy metabolism.

Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men (2015)
Journal Article
Stephens, F. B., Chee, C., Wall, B. T., Murton, A. J., Shannon, C. E., van Loon, L. J., & Tsintzas, K. (2015). Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men. Diabetes, 64(5), https://doi.org/10.2337/db14-0961

The ability to maintain skeletal muscle mass appears to be impaired in insulin-resistant conditions, such as type 2 diabetes, that are characterized by muscle lipid accumulation. The current study investigated the effect of acutely increasing lipid a... Read More about Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino acid ingestion in healthy young men.

Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation (2014)
Journal Article
Stephens, F. B., Mendis, B., Shannon, C. E., Cooper, S., Ortori, C. A., Barrett, D. A., Mansell, P., & Tsintzas, K. (2014). Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation. Clinical Science, 127(5), 315-322. https://doi.org/10.1042/cs20140031

Acylcarnitine accumulation in skeletal muscle and plasma has been observed in numerous models of mitochondrial lipid overload and insulin resistance. Fish oil n3PUFA (omega-3 polyunsaturated fatty acids) are thought to protect against lipid-induced i... Read More about Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation.

Photoperiodic regulation of FGF21 production in the Siberian hamster (2014)
Journal Article
Samms, R. J., Fowler, M. J., Cooper, S., Emmerson, P., Coskun, T., Adams, A. C., Kharitonenkov, A., Tsintzas, K., & Ebling, F. J. (2014). Photoperiodic regulation of FGF21 production in the Siberian hamster. Hormones and Behavior, 66(1), 180-185. https://doi.org/10.1016/j.yhbeh.2014.03.013

FGF21 is an endocrine member of the fibroblast growth factor superfamily that has been shown to play an important role in the physiological response to nutrient deprivation. Food restriction enhances hepatic FGF21 production, which serves to engage a... Read More about Photoperiodic regulation of FGF21 production in the Siberian hamster.

The causal role of breakfast in energy balance and health: a randomized controlled trial in lean adults (2014)
Journal Article
Betts, J. A., Richardson, J. D., Chowdhury, E. A., Holman, G. D., Tsintzas, K., & Thompson, D. (2014). The causal role of breakfast in energy balance and health: a randomized controlled trial in lean adults. American Journal of Clinical Nutrition, 100(2), https://doi.org/10.3945/ajcn.114.083402

Background: Popular beliefs that breakfast is the most important meal of the day are grounded in cross-sectional observations that link breakfast to health, the causal nature of which remains to be explored under real-life conditions.
Objective: The... Read More about The causal role of breakfast in energy balance and health: a randomized controlled trial in lean adults.

Increased Responses to the Actions of Fibroblast Growth Factor 21 on Energy Balance and Body Weight in a Seasonal Model of Adiposity (2012)
Journal Article
Murphy, M., Samms, R., Warner, A., Bolborea, M., Barrett, P., Fowler, M. J., Brameld, J. M., Tsintzas, K., Kharitonenkov, A., Adams, A. C., Coskun, T., & Ebling, F. J. (2013). Increased Responses to the Actions of Fibroblast Growth Factor 21 on Energy Balance and Body Weight in a Seasonal Model of Adiposity. Journal of Neuroendocrinology, 25(2), 180-189. https://doi.org/10.1111/j.1365-2826.2012.02383.x

The present study aimed to investigate the actions of fibroblast growth factor 21 (FGF21) on energy balance in a natural model of relative fatness, the Siberian hamster. Hamsters were studied under long days (LD) to promote weight gain, or short days... Read More about Increased Responses to the Actions of Fibroblast Growth Factor 21 on Energy Balance and Body Weight in a Seasonal Model of Adiposity.

Increased Expression of Hepcidin and Toll-Like Receptors 8 and 10 in Viral Keratitis (2011)
Journal Article
Mohammed, I., Abedin, A., Tsintzas, K., Abedin, S. A., Otri, A. M., Hopkinson, A., Mathew, M., & Dua, H. S. (2011). Increased Expression of Hepcidin and Toll-Like Receptors 8 and 10 in Viral Keratitis. Cornea, 30(8), 899-904. https://doi.org/10.1097/ICO.0b013e31820126e5

Purpose:

Antimicrobial peptides (AMPs) and toll-like receptors (TLRs) form part of the “chemical barrier” of the ocular surface to microbes. Evidence suggests that pathogen recognition by TLR releases AMPs, altering AMP-TLR profiles in pathologic... Read More about Increased Expression of Hepcidin and Toll-Like Receptors 8 and 10 in Viral Keratitis.