Dr CAROLINE RICK's Outputs (31)

Physiotherapy and occupational therapy vs no therapy in mild to moderate Parkinson disease: a randomized clinical trial (2016)
Journal Article
Clarke, C. E., Patel, S., Ives, N., Dowling, F., Rick, C. E., Woolley, R., Wheatley, K., Walker, M. F., & Sackley, C. M. (in press). Physiotherapy and occupational therapy vs no therapy in mild to moderate Parkinson disease: a randomized clinical trial. JAMA Neurology, 73(3), https://doi.org/10.1001/jamaneurol.2015.4452

IMPORTANCE It is unclear whether physiotherapy and occupational therapy are clinically effective and cost-effective in Parkinson disease (PD).
OBJECTIVE To perform a large pragmatic randomized clinical trial to evaluate the clinical effectiveness of... Read More about Physiotherapy and occupational therapy vs no therapy in mild to moderate Parkinson disease: a randomized clinical trial.

A systematic review of interventions to reduce hospitalisation in Parkinson's disease (2016)
Journal Article
Muzerengi, S., Herd, C., Rick, C., & Clarke, C. (2016). A systematic review of interventions to reduce hospitalisation in Parkinson's disease. Parkinsonism and Related Disorders, 24, 3-7. https://doi.org/10.1016/j.parkreldis.2016.01.011

The neurodegenerative process in Parkinson's disease (PD) results in a relentless progression of motor and non-motor symptoms. Affected individuals are frequently hospitalised for complications of the disease including falls, fractures, infections, a... Read More about A systematic review of interventions to reduce hospitalisation in Parkinson's disease.

A cluster randomised feasibility trial evaluating nutritional interventions in the treatment of malnutrition in care home adult residents (2015)
Journal Article
Stow, R., Ives, N., Smith, C., Rick, C., & Rushton, A. (2015). A cluster randomised feasibility trial evaluating nutritional interventions in the treatment of malnutrition in care home adult residents. Trials, 16(1), 1-21. https://doi.org/10.1186/s13063-015-0952-2

Comparing results from long and short form versions of the Parkinson's disease questionnaire in a longitudinal study (2015)
Journal Article
Jenkinson, C., Clarke, C., Gray, R., Hewitson, P., Ives, N., Morley, D., Rick, C., Wheatley, K., & Williams, A. (2015). Comparing results from long and short form versions of the Parkinson's disease questionnaire in a longitudinal study. Parkinsonism and Related Disorders, 21(11), 1312-1316. https://doi.org/10.1016/j.parkreldis.2015.09.008

A cluster randomised feasibility trial evaluating six-month nutritional interventions in the treatment of malnutrition in care home-dwelling adults: recruitment, data collection and protocol (2015)
Journal Article
Stow, R., Rushton, A., Ives, N., Smith, C., & Rick, C. (2015). A cluster randomised feasibility trial evaluating six-month nutritional interventions in the treatment of malnutrition in care home-dwelling adults: recruitment, data collection and protocol. Pilot and Feasibility Studies, 1(3), https://doi.org/10.1186/2055-5784-1-3

Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial (2014)
Journal Article
Daniels, J., Gray, R., Ives, N., Rick, C., Patel, S., Gray, A., Jenkinson, C., Mcintosh, E., Wheatley, K., Williams, A., & Clarke, C. (2014). Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial. Lancet, 384(9949), 1196-1205. https://doi.org/10.1016/S0140-6736%2814%2960683-8

Background
Whether initial treatment for Parkinson's disease should consist of levodopa, dopamine agonists, or monoamine oxidase type B inhibitors (MAOBI) is uncertain. We aimed to establish which of these three classes of drug, as initial treatment... Read More about Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial.

Lee Silverman voice treatment versus standard NHS speech and language therapy versus control in Parkinson's disease (PD COMM pilot): study protocol for a randomized controlled trial (2014)
Journal Article
Sackley, C. M., Smith, C. H., Rick, C., Brady, M. C., Ives, N., Patel, R., Roberts, H., Dowling, F., Jowett, S., Wheatley, K., Patel, S., Kelly, D., Sands, G., & Clarke, C. (2014). Lee Silverman voice treatment versus standard NHS speech and language therapy versus control in Parkinson's disease (PD COMM pilot): study protocol for a randomized controlled trial. Trials, 15, Article 213. https://doi.org/10.1186/1745-6215-15-213

Background: Parkinson’s disease is a common movement disorder affecting approximately 127,000 people in the UK, with an estimated two thirds having speech-related problems. Currently there is no preferred approach to speech and language therapy withi... Read More about Lee Silverman voice treatment versus standard NHS speech and language therapy versus control in Parkinson's disease (PD COMM pilot): study protocol for a randomized controlled trial.

PD REHAB: a large pragmatic randomised controlled trial of physiotherapy and occupational therapy versus no therapy in mild to moderate Parkinson's disease (2014)
Journal Article
Clarke, C., Patel, S., Woolley, R., Ives, N., Rick, C., Dowling, F., Wheatley, K., Walker, M. F., & Sackley, C. (in press). PD REHAB: a large pragmatic randomised controlled trial of physiotherapy and occupational therapy versus no therapy in mild to moderate Parkinson's disease. Movement Disorders, 29(Supp.1), Article s600. https://doi.org/10.1002/mds.25914

Should treatment for Parkinson's disease start immediately on diagnosis or delayed until functional disability develops? (2011)
Journal Article
Clarke, C. E., Patel, S., Ives, N., Rick, C., Wheatley, K., & Gray, R. (2011). Should treatment for Parkinson's disease start immediately on diagnosis or delayed until functional disability develops?. Movement Disorders, 26(7), 1187-1193. https://doi.org/10.1002/mds.23519

Background:

Evidence from clinical trials with monoamine oxidase type B inhibitors (TEMPO, ADAGIO and DATATOP) and levodopa (ELLDOPA) suggests that Parkinson's disease patients may benefit from treatment being commenced immediately on diagnosis ra... Read More about Should treatment for Parkinson's disease start immediately on diagnosis or delayed until functional disability develops?.

Systematic review of levodopa dose equivalency reporting in Parkinson's disease: Systematic Review of LED Reporting in PD (2010)
Journal Article
Tomlinson, C. L., Stowe, R., Patel, S., Rick, C., Gray, R., & Clarke, C. E. (2010). Systematic review of levodopa dose equivalency reporting in Parkinson's disease: Systematic Review of LED Reporting in PD. Movement Disorders, 25(15), 2649-2653. https://doi.org/10.1002/mds.23429

Interpretation of clinical trials comparing different drug regimens for Parkinson's disease (PD) is complicated by the different dose intensities used: higher doses of levodopa and, possibly, other drugs produce better symptomatic control but more la... Read More about Systematic review of levodopa dose equivalency reporting in Parkinson's disease: Systematic Review of LED Reporting in PD.

Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trial (2010)
Journal Article
Williams, A., Gill, S., Varma, T., Jenkinson, C., Quinn, N., Mitchell, R., Scott, R., Ives, N., Rick, C., Daniels, J., Patel, S., & Wheatley, K. (2010). Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trial. Lancet Neurology, 9(6), 581-591. https://doi.org/10.1016/s1474-4422%2810%2970093-4