SmokeHaz: systematic reviews and meta-analyses of the effects of smoking on respiratory health

Jayes, Leah; Haslam, Patricia L.; Gratziou, Christina G.; Powell, Pippa; Britton, John; Vardavas, Constantine; Jimenez-Ruiz, Carlos; Leonardi-Bee, Jo

Abstract

Background: Smoking tobacco increases the risk of respiratory disease in adults and children, but communicating the magnitude of these effects in a scientific manner that is accessible and usable by public and policymakers presents a challenge. We have therefore summarised scientific data on the impact of smoking on respiratory diseases to provide the content for a unique resource, SmokeHaz.

Methods: We conducted systematic reviews and meta-analyses of longitudinal studies (published to 2013) identified from electronic databases, grey literature, and experts. Random effect meta-analyses were used to pool the findings.

Results: We included 216 papers. Among adult smokers, we confirmed substantially increased risks of lung cancer (Risk Ratio (RR) 10.92, 95% CI 8.28-14.40; 34 studies), COPD (RR 4.01, 95% CI 3.18-5.05; 22 studies) and asthma (RR 1.61, 95% CI 1.07-2.42; 8 studies). Exposure to passive smoke significantly increased the risk of lung cancer in adult non-smokers; and increased the risks of asthma, wheeze, lower respiratory infections, and reduced lung function in children. Smoking significantly increased the risk of sleep apnoea, and asthma exacerbations in adult and pregnant populations; and active and passive smoking increased the risk of tuberculosis.

Conclusions: These findings have been translated into easily digestible content and published on the SmokeHaz website (www.smokehaz.eu).

Citation

Jayes, L., Haslam, P. L., Gratziou, C. G., Powell, P., Britton, J., Vardavas, C., Jimenez-Ruiz, C., & Leonardi-Bee, J. (2016). SmokeHaz: systematic reviews and meta-analyses of the effects of smoking on respiratory health. Chest, 150(1), https://doi.org/10.1016/j.chest.2016.03.060

• Journal Article Type: Article
• Acceptance Date: Mar 30, 2016
• Online Publication Date: Apr 19, 2016
• Publication Date: Jul 1, 2016
• Deposit Date: May 20, 2016
• Publicly Available Date: May 20, 2016
• Journal: Chest
• Print ISSN: 0012-3692
• Electronic ISSN: 1931-3543
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 150
• Issue: 1
• DOI: https://doi.org/10.1016/j.chest.2016.03.060
• Keywords: Smoking, Passive Smoking, Systematic Review, Meta-Analysis, Respiratory Diseases, Lung Diseases, Health Risks, Policy Makers, Public Awareness
• Public URL: https://nottingham-repository.worktribe.com/output/976112
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S0012369216485478
• Contract Date: May 20, 2016