Fast Event-Related Mapping of Population Fingertip Tuning Properties in Human Sensorimotor Cortex at 7T

Khalife, Sarah; Francis, Susan T.; Schluppeck, Denis; Sánchez-Panchuelo, Rosa Maria; Besle, Julien

Abstract

fMRI studies that investigate somatotopic tactile representations in the human cortex typically use either block or phase-encoded stimulation designs. Event-related (ER) designs allow for more flexible and unpredictable stimulation sequences than the other methods, but they are less efficient. Here, we compared an efficiency-optimized fast ER design (2.8-s average intertrial interval; ITI) to a conventional slow ER design (8-s average ITI) for mapping voxelwise fingertip tactile tuning properties in the sensorimotor cortex of six participants at 7 Tesla. The fast ER design yielded more reliable responses compared with the slow ER design, but with otherwise similar tuning prop-erties. Concatenating the fast and slow ER data, we demonstrate in each individual brain the existence of two sep-arate somatotopically-organized tactile representations of the fingertips, one in the primary somatosensory cortex (S1) on the postcentral gyrus, and the other shared across the motor and premotor cortices on the precentral gyrus. In both S1 and motor representations, fingertip selectivity decreased progressively, from narrowly-tuned Brodmann area (BA) 3b and BA4a, respectively, toward associative parietal and frontal regions that responded equally to all fingertips, suggesting increasing information integration along these two pathways. In addition, fingertip selectivity in S1 decreased from the cortical representation of the thumb to that of the pinky.

Citation

Khalife, S., Francis, S. T., Schluppeck, D., Sánchez-Panchuelo, R. M., & Besle, J. (2022). Fast Event-Related Mapping of Population Fingertip Tuning Properties in Human Sensorimotor Cortex at 7T. eNeuro, 9(5), 1-18. https://doi.org/10.1523/ENEURO.0069-22.2022

• Journal Article Type: Article
• Acceptance Date: Jul 31, 2022
• Online Publication Date: Sep 1, 2022
• Publication Date: Sep 1, 2022
• Deposit Date: Aug 1, 2022
• Publicly Available Date: Sep 1, 2022
• Journal: eNeuro
• Electronic ISSN: 2373-2822
• Publisher: Society for Neuroscience
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 5
• Article Number: 0069-22
• Pages: 1-18
• DOI: https://doi.org/10.1523/ENEURO.0069-22.2022
• Keywords: General Medicine; General Neuroscience
• Public URL: https://nottingham-repository.worktribe.com/output/9580782
• Publisher URL: https://www.eneuro.org/content/9/5/ENEURO.0069-22.2022