Development of a nanocapsule-loaded hydrogel for drug delivery for intraperitoneal administration

Teja Surikutchi, Bhanu; Obenza-Otero, Rebeca; Russo, Emanuele; Zelzer, Mischa; Golán Cancela, Irene; Costoya, José A.; Crecente Campo, José; José Alonso, Maria; Marlow, Maria

Abstract

Intraperitoneal (IP) drug delivery of chemotherapeutic agents, administered through hyperthermal intraperitoneal chemotherapy (HIPEC) and pressurized intraperitoneal aerosolized chemotherapy (PIPAC), is effective for the treatment of peritoneal malignancies. However, these therapeutic interventions are cumbersome in terms of surgical practice and are often associated with the formation of peritoneal adhesions, due to the catheters inserted into the peritoneal cavity during these procedures. Hence, there is a need for the development of drug delivery systems that can be administered into the peritoneal cavity. In this study, we have developed a nanocapsule (NCs)-loaded hydrogel for drug delivery in the peritoneal cavity. The hydrogel has been developed using poly(ethylene glycol) (PEG) and thiol-maleimide chemistry. NCs-loaded hydrogels were characterized by rheology and their resistance to dilution and drug release were determined in vitro. Using IVIS® to measure individual organ and recovered gel fluorescence intensity, an in vivo imaging study was performed and demonstrated that NCs incorporated in the PEG gel were retained in the IP cavity for 24 h after IP administration. NCs-loaded PEG gels could find potential applications as biodegradable, drug delivery systems that could be implanted in the IP cavity, for example at a the tumour resection site to prevent recurrence of microscopic tumours.

Citation

Teja Surikutchi, B., Obenza-Otero, R., Russo, E., Zelzer, M., Golán Cancela, I., Costoya, J. A., …Marlow, M. (2022). Development of a nanocapsule-loaded hydrogel for drug delivery for intraperitoneal administration. International Journal of Pharmaceutics, 622, Article 121828. https://doi.org/10.1016/j.ijpharm.2022.121828

• Journal Article Type: Article
• Acceptance Date: May 9, 2022
• Online Publication Date: May 17, 2022
• Publication Date: Jun 25, 2022
• Deposit Date: Aug 23, 2022
• Publicly Available Date: Aug 24, 2022
• Journal: International Journal of Pharmaceutics
• Print ISSN: 0378-5173
• Electronic ISSN: 1873-3476
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 622
• Article Number: 121828
• DOI: https://doi.org/10.1016/j.ijpharm.2022.121828
• Keywords: Pharmaceutical Science
• Public URL: https://nottingham-repository.worktribe.com/output/9579794
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0378517322003830?via%3Dihub