Injury among children and young people with and without attention deficit-hyperactivity disorder in the community: the risk of fractures, thermal injuries and poisonings

Prasad, Vibhore; West, Joe; Sayal, Kapil; Kendrick, Denise

Abstract

Background: Injuries commonly cause morbidity and mortality in children and young people (CYP). Attention deficit-hyperactivity disorder (ADHD) is the commonest neurobehavioural disorder in CYP and is associated with increased injury risk. However, large, population-based estimates of the risk of specific injuries are lacking. We aimed to provide estimates of the risk of fractures, thermal injuries and poisonings in CYP with and without ADHD.
Methods: In this population-based cohort study we used primary and secondary care medical records from England from the Clinical Practice Research Datalink (CPRD). There were 15,126 CYP with ADHD frequency-matched to 263,724 without, aged 3-17 years at diagnosis. The risk of: (i) fractures (ii) thermal injuries, and (iii) poisonings in CYP with ADHD was compared to those without.
Results: The absolute rate of injury per thousand person years at risk in CYP with vs. without ADHD was: fracture 28.9 (95%CI 27.5 to 30.3) vs. 18.7 (95%CI 18.5 to 19.0); long bone fracture 17.7 (95%CI 16.7 to 18.8) vs. 11.8 (95%CI 11.6 to 12.0); thermal injuries 4.4 (95%CI 3.9 to 4.9) vs. 2.2 (95%CI 2.1 to 2.3); poisonings 6.3 (95%CI 5.7 to 6.9) vs. 1.9 (95%CI 1.9 to 2.0). Adjusting for age, sex, geographical region, deprivation and calendar year, CYP with ADHD had: 25% increase in risk of fracture, (hazard ratio, HR=1.25 (95% CI 1.19 to 1.31)); 21% increase in risk of long bone fracture, (HR=1.21 (95% CI 1.13 to 1.28)); double the risk of thermal injury (HR=2.00 (95% CI 1.76 to 2.27) and almost four times the risk of poisoning (HR=3.72 (95% CI 3.32 to 4.17).
Conclusions: CYP with ADHD are at greater risk of fracture, thermal injury and poisoning compared to those without. Paediatricians and healthcare professionals should provide injury prevention advice at diagnosis and reviews.

Citation

Prasad, V., West, J., Sayal, K., & Kendrick, D. (2018). Injury among children and young people with and without attention deficit-hyperactivity disorder in the community: the risk of fractures, thermal injuries and poisonings. Child: Care, Health and Development, 44(6), 871-878. https://doi.org/10.1111/cch.12591

• Journal Article Type: Article
• Acceptance Date: Jun 16, 2018
• Online Publication Date: Jul 24, 2018
• Publication Date: Nov 30, 2018
• Deposit Date: Jul 5, 2018
• Publicly Available Date: Jul 25, 2019
• Journal: Child: Care, Health and Development
• Print ISSN: 0305-1862
• Electronic ISSN: 1365-2214
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 44
• Issue: 6
• Pages: 871-878
• DOI: https://doi.org/10.1111/cch.12591
• Keywords: Attention Deficit-Hyperactivity Disorder (ADHD); injury; fracture; thermal injury; poisoning
• Public URL: https://nottingham-repository.worktribe.com/output/939136
• Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/cch.12591
• Additional Information: This is the peer reviewed version of the following article: Prasad V, West J, Sayal K, Kendrick D. Injury among children and young people with and without attention deficit-hyperactivity disorder in the community: the risk of fractures, thermal injuries and poisonings. Child: Care, Health and Development 2018: Published Online First: 24 July 2018 doi: 10.1111/cch.12591 which has been published in final form at https://doi.org/10.1111/cch.12591 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
• Contract Date: Jul 5, 2018