Kazi M. Zakir Hossain
Single solvent based film casting method for the production of porous polymer films
Hossain, Kazi M. Zakir; Felfel, Reda M.; Ogbilikana, Prince S.; Thakker, Dhruma; Grant, David M.; Scotchford, C.A.; Ahmed, Ifty
Authors
Reda M. Felfel
Prince S. Ogbilikana
Dhruma Thakker
Professor DAVID GRANT DAVID.GRANT@NOTTINGHAM.AC.UK
PROFESSOR OF MATERIALS SCIENCE
Dr COLIN SCOTCHFORD COLIN.SCOTCHFORD@NOTTINGHAM.AC.UK
ASSOCIATE PROFESSOR
Professor IFTY AHMED ifty.ahmed@nottingham.ac.uk
PROFESSOR OF MATERIALS SCIENCE AND ENGINEERING
Abstract
A single solvent based film casting process for fabricating porous polymer films was developed in this study. The porous film was produced by mixing concentrated polylactic acid/ chloroform solution (20 wt%) and fresh chloroform solvent followed by film casting. The average pore sizes of the films produced were seen to increase from 2.1 (±0.1) µm to 6.4 (±0.2) µm with increasing ratio of concentrated PLA solution and fresh solvent from 1:2 to 1:4. Functional groups of PLA after casting into porous film were confirmed via Fourier transform infrared (FTIR) spectroscopy analysis. Cytocompatibility studies (via Alamar Blue assessment) utilising MG-63 cells on the porous PLA films revealed an increase in cell metabolic activity up to 8 days post-seeding. In addition, these direct cell culture studies showed that the porous membranes supported cell adhesion and growth not only on the surface but also through the porous structures of the membrane, highlighting the suitability of these porous films in tissue engineering applications.
Citation
Hossain, K. M. Z., Felfel, R. M., Ogbilikana, P. S., Thakker, D., Grant, D. M., Scotchford, C., & Ahmed, I. (2018). Single solvent based film casting method for the production of porous polymer films. Macromolecular Materials and Engineering, 303, https://doi.org/10.1002/mame.201700628
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Feb 7, 2018 |
| Online Publication Date | Feb 7, 2018 |
| Publication Date | Apr 17, 2018 |
| Deposit Date | May 11, 2018 |
| Journal | Macromolecular Materials and Engineering |
| Print ISSN | 1438-7492 |
| Electronic ISSN | 1439-2054 |
| Publisher | Wiley |
| Peer Reviewed | Peer Reviewed |
| Volume | 303 |
| DOI | https://doi.org/10.1002/mame.201700628 |
| Public URL | https://nottingham-repository.worktribe.com/output/926157 |
| Publisher URL | https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.201700628 |
| Contract Date | May 11, 2018 |
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