Aerosol and droplet generation in upper and lower GI endoscopy: whole procedure and event-based analysis

Phillips, Frank; Crowley, Jane; Warburton, Samantha; Gordon, George S.D.; Parra-Blanco, Adolfo

Abstract

Background and Aims: Aerosol-generating procedures have become an important healthcare issue during the coronavirus disease 2019 (COVID-19) pandemic because the severe acute respiratory syndrome coronavirus 2 virus can be transmitted through aerosols. We aimed to characterize aerosol and droplet generation in GI endoscopy, where there is little evidence. Methods: This prospective observational study included 36 patients undergoing routine peroral gastroscopy (POG), 11 undergoing transnasal endoscopy (TNE), and 48 undergoing lower GI (LGI) endoscopy. Particle counters took measurements near the appropriate orifice (2 models were used with diameter ranges of .3-25 μm and 20-3000 μm). Quantitative analysis was performed by recording specific events and subtracting background particles. Results: POG produced 1.96 times the level of background particles (P < .001) and TNE produced 2.00 times (P < .001), but a direct comparison showed POG produced 2.00 times more particles than TNE. LGI procedures produced significant particle counts (P < .001) with 2.4 times greater production per procedure than POG but only .63 times production per minute. Events that were significant relative to the room background particle count were POG, with throat spray (150.0 times, P < .001), esophageal extubation (37.5 times, P < .001), and coughing or gagging (25.8 times, P < .01); TNE, with nasal spray (40.1 times, P < .001), nasal extubation (32.0 times, P < .01), and coughing or gagging (20.0, P < .01); and LGI procedures, with rectal intubation (9.9 times, P < .05), rectal extubation (27.2 times, P < .01), application of abdominal pressure (9.6 times, P < .05), and rectal insufflation or retroflexion (7.7 times, P < .01). These all produced particle counts larger than or comparable with volitional cough. Conclusions: GI endoscopy performed through the mouth, nose, or rectum generates significant quantities of aerosols and droplets. Because the infectivity of procedures is not established, we therefore suggest adequate personal protective equipment is used for all GI endoscopy where there is a high population prevalence of COVID-19. Avoiding throat and nasal spray would significantly reduce particles generated from upper GI procedures.

• Journal Article Type: Article
• Acceptance Date: May 24, 2022
• Online Publication Date: Jun 1, 2022
• Publication Date: Oct 1, 2022
• Deposit Date: Jun 8, 2022
• Publicly Available Date: Jun 2, 2023
• Journal: Gastrointestinal Endoscopy
• Print ISSN: 0016-5107
• Electronic ISSN: 1097-6779
• Publisher: Elsevier BV
• Peer Reviewed: Peer Reviewed
• Volume: 96
• Issue: 3
• Pages: 603-611.E0
• DOI: https://doi.org/10.1016/j.gie.2022.05.018
• Keywords: Gastroenterology; Radiology, Nuclear Medicine and imaging
• Public URL: https://nottingham-repository.worktribe.com/output/8310029
• Publisher URL: https://www.giejournal.org/article/S0016-5107(22)01731-X/fulltext