Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial: Oral Glutamine Supplementation in Cystic Fibrosis

Forrester, Doug L.; Knox, Alan J.; Smyth, Alan R.; Barr, Helen L.; Simms, Rebecca; Pacey, Sarah J.; Pavord, Ian D.; Honeybourne, David; Dewar, Jane; Clayton, Andy; Fogarty, Andrew W.

Abstract

Rationale: Pulmonary infection and malnutrition in cystic fibrosis are associated with decreased survival. Glutamine has a possible anti-microbial effect, with a specific impact against Pseudomonas aeruginosa. We aimed to test the hypothesis that oral glutamine supplementation (21 g/day) for 8 weeks in adults with cystic fibrosis would decrease pulmonary inflammation and improve clinical status.

Methods: The study design was a randomized double-blind placebo-controlled study design with an iso-nitrogenous placebo. The primary analysis was intention to treat, and the primary outcome was change in induced sputum neutrophils.

Results: Thirty-nine individuals were recruited and thirty-six completed the study. Glutamine supplementation had no impact on any of the outcome measures in the intention-to-treat analysis. In the per protocol analysis, glutamine supplementation was associated with an increase in induced sputum neutrophils (P = 0.046), total cells (P = 0.03), and in Pseudomonas isolation agar colony forming units (P = 0.04) compared to placebo.

Conclusions: There was no effect of glutamine supplementation on markers of pulmonary inflammation in the intention-to-treat analysis.

Citation

Forrester, D. L., Knox, A. J., Smyth, A. R., Barr, H. L., Simms, R., Pacey, S. J., Pavord, I. D., Honeybourne, D., Dewar, J., Clayton, A., & Fogarty, A. W. (2016). Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial: Oral Glutamine Supplementation in Cystic Fibrosis. Pediatric Pulmonology, 51(3), 253-257. https://doi.org/10.1002/ppul.23370

• Journal Article Type: Article
• Acceptance Date: Oct 26, 2015
• Online Publication Date: Dec 27, 2015
• Publication Date: 2016-03
• Deposit Date: Oct 20, 2016
• Publicly Available Date: Oct 20, 2016
• Journal: Pediatric Pulmonology
• Print ISSN: 8755-6863
• Electronic ISSN: 1099-0496
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 51
• Issue: 3
• Pages: 253-257
• DOI: https://doi.org/10.1002/ppul.23370
• Keywords: glutamine; cystic fibrosis; infection; nutrition
• Public URL: https://nottingham-repository.worktribe.com/output/768625
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1002/ppul.23370/abstract
• Additional Information: "This is the peer reviewed version of the following article: Doug L. Forrester, Alan J. Knox, Alan R. Smyth, Helen L. Barr, Rebecca Simms, Sarah J. Pacey, Ian D. Pavord, David Honeybourne, Jane Dewar, Andy Clayton and Andrew W. Fogarty. (2016) Pediatric pulmonary 51 (3): 253-257, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/ppul.23370/full; This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
• Contract Date: Oct 20, 2016