Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound

Vaithilingam, Jayasheelan; Kilsby, Samuel; Goodridge, Ruth D.; Christie, Steven D.R.; Edmondson, Steve; Hague, Richard J.M.

Abstract

Surface modification of an implant with a biomolecule is used to improve its biocompatibility and to reduce post-implant complications. In this study, a novel approach has been used to functionalise phosphonic acid monolayers with a drug. Ti6Al4V components fabricated using selective laser melting (SLM) were functionalised with Paracetamol (a pharmaceutically relevant biomolecule) using phosphonic acid based self-assembled monolayers (SAMs). The attachment, stability of the monolayers on the SLM fabricated surface and functionalisation of SAMs with Paracetamol were studied using X-ray photoelectron spectroscopy (XPS) and surface wettability measurements. The obtained results confirmed that SAMs were stable on the Ti6Al4V surface for over four weeks and then began to desorb from the surface. The reaction used to functionalise the phosphonic acid monolayers with Paracetamol was noted to be successful. Thus, the proposed method has the potential to immobilise drugs/proteins to SAM coated surfaces and improve their biocompatibility and reduce post-implant complications.

Citation

Vaithilingam, J., Kilsby, S., Goodridge, R. D., Christie, S. D., Edmondson, S., & Hague, R. J. (2015). Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound. Materials Science and Engineering: C, 46, 52-61. https://doi.org/10.1016/j.msec.2014.10.015

• Journal Article Type: Article
• Acceptance Date: Oct 2, 2014
• Online Publication Date: Oct 5, 2014
• Publication Date: Jan 1, 2015
• Deposit Date: Aug 8, 2017
• Publicly Available Date: Aug 8, 2017
• Journal: Materials Science and Engineering: C
• Print ISSN: 0928-4931
• Electronic ISSN: 1873-0191
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 46
• Pages: 52-61
• DOI: https://doi.org/10.1016/j.msec.2014.10.015
• Keywords: Selective laser melting (SLM), Self-assembled monolayers (SAMs), Additive manufacturingFunctionalisation, X-ray photoelectron spectroscopy (XPS)
• Public URL: https://nottingham-repository.worktribe.com/output/740328
• Publisher URL: https://doi.org/10.1016/j.msec.2014.10.015
• Contract Date: Aug 8, 2017