Serum troponin, D‐dimer, and CRP level in severe coronavirus (COVID‐19) patients

Ali, Ayad M.; Rostam, Hassan M.; Fatah, Mohammed H.; Noori, Chalak M.; Ali, Kameran M.; Tawfeeq, Hassan M.

Abstract

Background

Abnormal inflammation coagulation biomarker levels of troponin, C-reactive protein (CRP), and D-dimer levels in serum have been demonstrated to be associated and involved in the disease progression of coronavirus disease 2019 (COVID-19).
Methods

First: the study aimed to investigate the correlation of troponin, CRP, d-dimer, white blood cell (WBC) and polymerase chain reaction–cycle threshold (PCR-Ct) within COVID-19 survivors (143 patients; 79 males, 64 females) and in deceased (30 patients; 12 males, 18 females) group. Also, assessing any differences between both groups in studied parameters. Second: a correlation study of studied parameters' level has been conducted within families (41 patients; 23 males [seven deaths] and 18 females [eight deaths]) that lost more than one member due to the severity of the disease. Also, differences between these family and control group (132 patients; 69 males and 63 females) group in studied parameters have been assessed.
Results

In the first week of hospitalization, there were significant differences in D-dimer, CRP and troponin level between survived and deceased patient groups. In the second week of the admission, both groups had significant differences in the level of all studied parameters; troponin I, D-dimer, CRP, and WBCs. WBC levels positively correlated to CRP in male survivors (r = 0.75, p < 0.0001), and to troponin in deceased male patients (r = 0.74, p = 0.007). The second week of patient admission was critical in the group of families who lost more than one person, when troponin was correlated positively with D-dimer, CRP, and WBCs.
Conclusion

Troponin, D-dimer, CRP, and WBCs level were significantly higher in COVID-19 patients who died than in COVID-19 survivors. High troponin and WBC levels, were considerably associated with families that lost more than one member, when compared with the unrelated COVID-19 patient control.

Citation

Ali, A. M., Rostam, H. M., Fatah, M. H., Noori, C. M., Ali, K. M., & Tawfeeq, H. M. (2022). Serum troponin, D‐dimer, and CRP level in severe coronavirus (COVID‐19) patients. Immunity, Inflammation and Disease, 10(3), Article e582. https://doi.org/10.1002/iid3.582

• Journal Article Type: Article
• Acceptance Date: Dec 3, 2021
• Online Publication Date: Dec 22, 2021
• Publication Date: 2022-03
• Deposit Date: Jan 4, 2022
• Publicly Available Date: Jan 4, 2022
• Journal: Immunity, Inflammation and Disease
• Electronic ISSN: 2050-4527
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 3
• Article Number: e582
• DOI: https://doi.org/10.1002/iid3.582
• Keywords: Immunology; Immunology and Allergy
• Public URL: https://nottingham-repository.worktribe.com/output/7162732
• Publisher URL: https://onlinelibrary.wiley.com/doi/full/10.1002/iid3.582