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Dietary interventions reduce traditional and novel cardiovascular risk markers by altering the gut microbiome and their metabolites

Vijay, Amrita; Astbury, Stuart; Panayiotis, Louca; Marques, Francine; Spector, Tim D; Menni, Cristina; Valdes, Ana M

Dietary interventions reduce traditional and novel cardiovascular risk markers by altering the gut microbiome and their metabolites Thumbnail


Authors

Louca Panayiotis

Francine Marques

Tim D Spector

Cristina Menni



Abstract

Aims: The current study investigates the role of diet in mediating the gut microbiome-cardiovascular association which has not
yet been explored in humans.
Methods and results: Using a two-arm dietary intervention study in healthy participants (N=70), we assessed the effects of
omega-3 and fibre supplementation on gut microbiome composition and short-chain fatty acid (SCFA) production. We then
investigated how changes in gut microbiome composition correlated with changes in traditional cardiovascular risk factors
(cholesterol, triglycerides, blood pressure), cytokines, and novel validated markers such as GlycA and ceramides, previously linked
to CVD incidence and mortality. Both interventions resulted in significant drops in blood pressure, cholesterol, proinflammatory
cytokines, GlycA and ceramides (all P

Citation

Vijay, A., Astbury, S., Panayiotis, L., Marques, F., Spector, T. D., Menni, C., & Valdes, A. M. (2021). Dietary interventions reduce traditional and novel cardiovascular risk markers by altering the gut microbiome and their metabolites. Frontiers in Cardiovascular Medicine, 8, Article 691564. https://doi.org/10.3389/fcvm.2021.691564

Journal Article Type Article
Acceptance Date Jun 8, 2021
Online Publication Date Jul 14, 2021
Publication Date Jul 14, 2021
Deposit Date Jul 6, 2021
Publicly Available Date Jul 14, 2021
Journal Frontiers in Cardiovascular Medicine
Electronic ISSN 2297-055X
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 8
Article Number 691564
DOI https://doi.org/10.3389/fcvm.2021.691564
Public URL https://nottingham-repository.worktribe.com/output/5758855
Publisher URL https://www.frontiersin.org/articles/10.3389/fcvm.2021.691564/full

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