Histological and immunohistochemical investigation of canine prostate carcinoma with identification of common intraductal carcinoma component

Brot, Simone; Lothion‐Roy, Jennifer; Grau‐Roma, Llorenç; White, Emily; Guscetti, Franco; Rubin, Mark A.; Mongan, Nigel P.

Abstract

A limited number of species, including men and dogs, spontaneously develop prostate cancer (PC). The histological and molecular relevance of canine PC as a model for the disease in men remains controversial. To address this challenge, this study aimed to assess the histomorphology and expression of basal cell, urothelial and neuroendocrine markers [p63, high molecular weight cytokeratin (HMWCK), Uroplakin 3 (UPIII), neuron-specific enolase (NSE)] in canine PC (n = 41). Based on histomorphology, 10/41 (24%), 21/41 (51%) and 9/41 (22%) were classified as adenocarcinoma (AC), urothelial carcinoma (UC), and mixed carcinoma, respectively. Tumour inflammation was common, frequently severe [20/41 (49%)], and associated with neutering (p 

Citation

Brot, S., Lothion‐Roy, J., Grau‐Roma, L., White, E., Guscetti, F., Rubin, M. A., & Mongan, N. P. (2022). Histological and immunohistochemical investigation of canine prostate carcinoma with identification of common intraductal carcinoma component. Veterinary and Comparative Oncology, 20(1), 38-49. https://doi.org/10.1111/vco.12704

• Journal Article Type: Article
• Acceptance Date: May 7, 2021
• Online Publication Date: May 7, 2021
• Publication Date: 2022-03
• Deposit Date: May 14, 2021
• Publicly Available Date: May 24, 2021
• Journal: Veterinary and Comparative Oncology
• Print ISSN: 1476-5810
• Electronic ISSN: 1476-5829
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 20
• Issue: 1
• Pages: 38-49
• DOI: https://doi.org/10.1111/vco.12704
• Keywords: General Veterinary
• Public URL: https://nottingham-repository.worktribe.com/output/5530673
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1111/vco.12704