Onosi Ifesemen
Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study
Ifesemen, Onosi; McWilliams, Daniel F.; Ferguson, Eamonn; Wakefield, Richard; Akin-Akinyosoye, Kehinde; Wilson, Deborah; Platts, Dorothy; Ledbury, Susan; Walsh, David A.
Authors
Dr DANIEL MCWILLIAMS DAN.MCWILLIAMS@NOTTINGHAM.AC.UK
Postdoctoral Research Fellow
EAMONN FERGUSON eamonn.ferguson@nottingham.ac.uk
Professor of Health Psychology
Richard Wakefield
Kehinde Akin-Akinyosoye
Deborah Wilson
Dorothy Platts
Susan Ledbury
DAVID WALSH david.walsh@nottingham.ac.uk
Professor of Rheumatology
Abstract
Background: Pain and fatigue are persistent problems in people with rheumatoid arthritis. Central sensitisation (CS) may contribute to pain and fatigue, even when treatment has controlled inflammatory disease. This study aims to validate a self-report 8-item questionnaire, the Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA) questionnaire, developed to measure central pain mechanisms in RA, and to predict patient outcomes and response to treatment. A secondary objective is to explore mechanisms linking CS, pain and fatigue in people with RA. Methods/design: This is a prospective observational cohort study recruiting 250 adults with active RA in secondary care. The CAP-RA questionnaire, demographic data, medical history, and patient reported outcome measures (PROMs) of traits associated with central sensitization will be collected using validated questionnaires. Quantitative sensory testing modalities of pressure pain detection thresholds, temporal summation and conditioned pain modulation will be indices of central sensitization, and blood markers, swollen joints and ultrasound scans will be indices of inflammation. Primary data collection will be at baseline and 12 weeks. The test-retest reliability of CAP-RA questionnaire will be determined 1 week after the baseline visit. Pain and fatigue data will be collected weekly via text messages for 12 weeks. CAP-RA psychometric properties, and predictive validity for outcomes at 3 months will be evaluated. Discussion: This study will validate a simple self-report questionnaire against psychophysical indices of central sensitization and patient reported outcome measures of traits associated with CS in a population of individuals with active RA. The application of this instrument in the clinical environment could provide a mechanism-based stratification tool to facilitate the provision of targeted therapy to individuals with pain and fatigue in RA, alongside treatments that target joint inflammation. Trial registration: Clinicaltrials.gov NCT04515589. Date of registration 17 August 2020.
Citation
Ifesemen, O., McWilliams, D. F., Ferguson, E., Wakefield, R., Akin-Akinyosoye, K., Wilson, D., …Walsh, D. A. (2021). Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study. BMC Rheumatology, 5(1), Article 23. https://doi.org/10.1186/s41927-021-00187-2
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 3, 2021 |
Online Publication Date | Jun 24, 2021 |
Publication Date | Dec 1, 2021 |
Deposit Date | Mar 4, 2021 |
Publicly Available Date | Jun 24, 2021 |
Journal | BMC Rheumatology |
Electronic ISSN | 2520-1026 |
Publisher | Springer Verlag |
Peer Reviewed | Peer Reviewed |
Volume | 5 |
Issue | 1 |
Article Number | 23 |
DOI | https://doi.org/10.1186/s41927-021-00187-2 |
Public URL | https://nottingham-repository.worktribe.com/output/5366430 |
Publisher URL | https://bmcrheumatol.biomedcentral.com/articles/10.1186/s41927-021-00187-2 |
Files
s41927-021-00187-2
(723 Kb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
You might also like
The rat Osteoarthritis Bone Score: a new histological system for scoring subchondral pathology in rat knees analogous to histological correlates of human OA bone marrow lesions
(2024)
Presentation / Conference Contribution
Influence of central aspects of pain on self-management in people with chronic low back pain
(2023)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search